期刊
SCIENTIFIC REPORTS
卷 12, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41598-022-25396-8
关键词
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资金
- Austrian Science Fund FWF [J4205, P28854, I3792, DK-MCD W1226, DOC-130]
- Swiss National Science Foundation [31003A_176127]
- Horizon 2020 program of the European Union [633589]
- Austrian Research Promotion Agency FFG [864690, 870454]
- Integrative Metabolism Research Center Graz
- Styrian Government (Zukunftsfonds, doc.funds program)
- City of Graz
- Austrian Exchange Service OEAD
- BioTechMed-Graz (Flagship project DYNIMO)
- Austrian Infrastructure Program 2016/2017
- Austrian Science Fund (FWF) [I3792, J4205] Funding Source: Austrian Science Fund (FWF)
- Swiss National Science Foundation (SNF) [31003A_176127] Funding Source: Swiss National Science Foundation (SNF)
C57BL/6NRj mice are an ideal model for studying cellular alterations in metabolism, and age-related metabolic alterations occur at an early stage and may be associated with a metabolic switch. There are sex-specific differences in the metabolite signatures of different tissues, and metabolomic features are highly dependent on the genetic background of mouse strains.
Due to intact reactive oxygen species homeostasis and glucose metabolism, C57BL/6NRj mice are especially suitable to study cellular alterations in metabolism. We applied Nuclear Magnetic resonance spectroscopy to analyze five different tissues of this mouse strain during aging and included female and male mice aged 3, 6, 12, and 24 months. Metabolite signatures allowed separation between the age groups in all tissues, and we identified the most prominently changing metabolites in female and male tissues. A refined analysis of individual metabolite levels during aging revealed an early onset of age-related changes at 6 months, sex-specific differences in the liver, and a biphasic pattern for various metabolites in the brain, heart, liver, and lung. In contrast, a linear decrease of amino acids was apparent in muscle tissues. Based on these results, we assume that age-related metabolic alterations happen at a comparably early aging state and are potentially associated with a metabolic switch. Moreover, identified differences between female and male tissues stress the importance of distinguishing between sexes when studying age-related changes and developing new treatment approaches. Besides, metabolomic features seem to be highly dependent on the genetic background of mouse strains.
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