Phase diagrams of PEG(1000,1500,2000,4000,6000) + lithium citrate plus water ATPSs, and the partitioning of salbutamol at T=298.15 K

Salbutamol is a drug used to treat the pulmonary diseases by ameliorate the medium and large airways in the lungs. Partitioning of salbutamol drug on the aqueous two-phase systems (ATPSs) of PEG(1000,1500,2000,4000,6000) + trilithium citrate + water was determined at T = 298.15 K. The effect of molecular mass of polymer (MMP) on the binodal and tie-line compositions were studied. Results showed that the biphasic area was extended as the MMP was increased. The salting-out ability were quantified using the Setschenow model, and the binodal curves were modeled by a nonlinear 3-parameter equation. Furthermore, electrolyte Wilson along with the osmotic virial models have adequately been implemented to fit the tie-line compositions. Also, the studied ATPSs were implemented to study the partitioning of salbutamol drug on the salt-affluent and polymer-affluent phases. It is observed that, ATPSs of PEG(1000) is premium to extract the salbutamol to the polymer-affluent phase, where, the ATPSs of PEG(6000) is more favorable to extract the drug to the salt-affluent phase.

Automated summary

Salbutamol is a drug used to treat pulmonary diseases by improving the medium and large airways in the lungs. The partitioning of salbutamol on ATPSs of PEG(1000,1500,2000,4000,6000) + trilithium citrate + water was studied, and the effect of polymer molecular mass on the binodal and tie-line compositions was investigated. The biphasic area expanded with increasing molecular mass of polymer. Salting-out ability was quantified using the Setschenow model, and the binodal curves were modeled using a nonlinear 3-parameter equation. Electrolyte Wilson and osmotic virial models were used to fit the tie-line compositions. The ATPSs of PEG(1000) were found to be preferable for extracting salbutamol to the polymer-affluent phase, while the ATPSs of PEG(6000) were more suitable for extracting the drug to the salt-affluent phase.