期刊
SCIENTIFIC REPORTS
卷 12, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41598-022-26306-8
关键词
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资金
- National Institute of Diabetes and Digestive and Kidney Diseases [R01DK109934]
- U.S. Department of Defense [DOD W81XWH-19-1-0429, 1R01DK131446, R01 DK120858, R01 NS078294, UF1NS111692]
- IDDRC from the Eunice Kennedy Shriver National Institute of Child Health and Human Development [P50 HD103555]
- NIH [DK059637, DK020593]
- McNair Medical Institute
Research has identified a circuit connecting the basal forebrain to the lateral habenula that modulates non-homeostatic feeding behavior. Glutamatergic neurons in the basal forebrain respond to various sensory cues, including aversive and food-related odors. Activation of this circuit drives aversion and suppresses the drive to eat in a fasted state.
Environmental cues and internal states such as mood, reward, or aversion directly influence feeding behaviors beyond homeostatic necessity. The hypothalamus has been extensively investigated for its role in homeostatic feeding. However, many of the neural circuits that drive more complex, non-homeostatic feeding that integrate valence and sensory cues (such as taste and smell) remain unknown. Here, we describe a basal forebrain (BF)-to-lateral habenula (LHb) circuit that directly modulates non-homeostatic feeding behavior. Using viral-mediated circuit mapping, we identified a population of glutamatergic neurons within the BF that project to the LHb, which responds to diverse sensory cues, including aversive and food-related odors. Optogenetic activation of BF-to-LHb circuitry drives robust, reflexive-like aversion. Furthermore, activation of this circuitry suppresses the drive to eat in a fasted state. Together, these data reveal a role of basal forebrain glutamatergic neurons in modulating LHb-associated aversion and feeding behaviors by sensing environmental cues.
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