期刊
SCIENTIFIC REPORTS
卷 12, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41598-022-23386-4
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资金
- King Saud University, Riyadh, Saudi Arabia [RSP-2021/165]
Recent breakthroughs in nanoparticle-based therapeutic delivery methods have revolutionized cancer therapy by enhancing penetration capability and disease management. In this study, isolongifolene-loaded chitosan nanoparticles were successfully synthesized and characterized. The nanoparticles demonstrated excellent hemocompatibility, plasma stability, and sustained drug release, suggesting their potential as adjuvants in combating multi-drug resistance in solid tumors.
Recent breakthroughs in the field of nanoparticle-based therapeutic delivery methods have changed the standpoint of cancer therapy by effectively delaying the process of disease development. Nanoparticles have a unique capacity of good penetrating ability than other therapeutic leads used in traditional therapeutics, and also, they have the highest impact on disease management. In the current study isolongifolene-loaded Chitosan nanoparticles have been formulated, synthesized and then characterized by the use of Fourier Transform Infrared Spectroscopy, X-ray Diffraction, Scanning Electron Microscopy and Transmission Electron Microscopy. Further, the characterized chitosan nano formulation was evaluated for hemocompatibility, plasma stability, and in-vitro release. Isolongifolene-loaded chitosan nanoparticles were found to be compatible with plasma and also, they exhibited a constant release pattern. Hence, chitosan-loaded nanoparticles could be employed as an excellent adjuvant in cancer therapeutic, to combat the multi-drug resistance in solid tumors.
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