Tris(4-azidophenyl)methanol - a novel and multifunctional thiol protecting group

The novel tris(4-azidophenyl)methanol, a multifunctionalisable aryl azide, is reported. The aryl azide can be used as a protecting group for thiols in peptoid synthesis and can be cleaved under mild reaction conditions via a Staudinger reduction. Moreover, the easily accessible aryl azide can be functionalised via copper-catalysed cycloaddition reactions, providing additional opportunities for materials chemistry applications.

Automated summary

In this article, a multifunctionalisable aryl azide, tris(4-azidophenyl)methanol, is reported. It can be used as a protecting group for thiols in peptoid synthesis and can be cleaved under mild reaction conditions via a Staudinger reduction. Additionally, the easily accessible aryl azide can be functionalised through copper-catalysed cycloaddition reactions, offering more possibilities for materials chemistry applications.