期刊
NUTRIENTS
卷 14, 期 24, 页码 -出版社
MDPI
DOI: 10.3390/nu14245382
关键词
rice germ; gamma-aminobutyric acid; chronic unpredictable mild stress; hypothalamic neuroinflammation; pyroptosis
资金
- Ministry of SMEs and Startups (MSS, Republic of Korea) [S3164953]
- Korea Technology & Information Promotion Agency for SMEs (TIPA) [S3164953] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
This study found that rice germ with 30% GABA (RG) can reduce neuroinflammation induced by chronic unpredictable mild stress (CUMS) and the associated depressive-like behavior.
Stress-induced neuroinflammation is widely regarded as one of the primary causes of depression. Gamma-aminobutyric acid (GABA)-enriched foods relieve stress and reduce inflammatory reactions. This study aimed to evaluate whether rice germ with 30% GABA (RG) reduced neuroinflammation in mice exposed to chronic unpredictable mild stress (CUMS). CUMS mice were administered 40, 90, and 140 mg/kg of RG. CUMS increased serum and hypothalamic pro-inflammatory cytokine (TNF-alpha and IL-6) levels, which were decreased by RG. In the hypothalamus, CUMS elevated M1-type microglia markers of CD86 and NF-kappa B, whereas RG lowered these levels. The expression levels of NLRP3 inflammasome complex (NLRP3, apoptosis-associated speck-like protein containing a caspase recruitment domain, and caspase-1), IL-1 beta, and IL-18 were increased in the hypothalamus of CUMS mice and decreased by RG. RG attenuated depressive-like behaviors in CUMS mice, as measured by the forced swim test and tail suspension test. In conclusion, RG decreased hypothalamic inflammation-related signals, such as TNF-alpha, IL-6, M1 polarization, NF-kappa B, NLRP3 inflammasome complex, caspase-1, IL-1 beta, and IL-18, to diminish depressive-like behavior.
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