The Inhibition of Autophagy and Pyroptosis by an Ethanol Extract of Nelumbo nucifera Leaf Contributes to the Amelioration of Dexamethasone-Induced Muscle Atrophy

Review Cell Biology

The Molecular Pathways of Pyroptosis in Atherosclerosis

Dan Song et al.

Summary: This article systematically reviews the molecular pathways of pyroptosis in atherosclerosis, providing a new perspective for the prevention and treatment of AS.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

添加到收藏夹

Review Cell Biology

Pyroptosis and Sarcopenia: Frontier Perspective of Disease Mechanism

Hongfu Jin et al.

Summary: With global ageing, the age-related disease sarcopenia has become a significant burden to individuals and society. In exploring the mechanism and intervention measures for sarcopenia, the role of pyroptosis, a kind of regulated cell death, is of interest. Chronic inflammation and poor skeletal muscle perfusion in ageing tissues can activate the pyroptosis pathway, and autophagy plays a protective role in inhibiting pyroptosis activation. Further studies are needed to understand the involvement of inflammatory factors and signaling pathways in pyroptosis in sarcopenia.

CELLS (2022)

添加到收藏夹

Review Neurosciences

Research Progress of Pyroptosis in Alzheimer's Disease

Weiyue Xue et al.

Summary: This article summarizes the current research on the role of neuron pyroptosis in AD, aiming to provide a comprehensive understanding of the pathogenesis of AD and potential therapeutic targets.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2022)

添加到收藏夹

Review Cell Biology

Molecular Mechanisms of Inflammation in Sarcopenia: Diagnosis and Therapeutic Update

Guadalupe Elizabeth Jimenez-Gutierrez et al.

Summary: Sarcopenia, an age-related condition, directly impacts quality of life and is associated with chronic diseases. Understanding the molecular mechanisms can improve prevention, diagnosis, and treatment. This article summarizes recent research on inflammation, therapeutic agents, and diagnostic techniques for sarcopenia.

CELLS (2022)

添加到收藏夹

Article Plant Sciences

Psoralea corylifolia L. seed extract attenuates dexamethasone-induced muscle atrophy in mice by inhibition of oxidative stress and inflammation

Eunhui Seo et al.

Summary: This study validated the beneficial effects of Psoralea corylifolia (PCS) extract on dexamethasone-induced muscle atrophy in mice. PCS extract inhibited muscle degradation factors and increased muscle regeneration and synthesis factors. This effect was likely mediated by suppressing oxidative stress and inflammation.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

添加到收藏夹

Review Medicine, Research & Experimental

Quercetin: A Molecule of Great Biochemical and Clinical Value and Its Beneficial Effect on Diabetes and Cancer

Aikaterini-Spyridoula Michala et al.

Summary: Quercetin is an important polyphenol with antioxidant properties that plays a positive role in oxidative stress, cancer, and blood sugar regulation. Although the specific daily intake of quercetin has not been determined, research shows that it is a valuable dietary antioxidant.

DISEASES (2022)

添加到收藏夹

Article Cell Biology

Trimetazidine attenuates dexamethasone-induced muscle atrophy via inhibiting NLRP3/GSDMD pathway-mediated pyroptosis

Li Wang et al.

Summary: This study suggests that NLRP3/GSDMD-mediated pyroptosis might be a novel mechanism for dexamethasone-induced skeletal muscle atrophy. Trimetazidine could be developed as a potential therapeutic agent for the treatment of dexamethasone-induced muscle atrophy.

CELL DEATH DISCOVERY (2021)

添加到收藏夹

Review Geriatrics & Gerontology

Inflammation and sarcopenia: A focus on circulating inflammatory cytokines

Linyuan Pan et al.

Summary: Sarcopenia, characterized by loss of muscle mass, reduced strength, and/or physical performance, is a major limitation to daily activities in the elderly, associated with increased incidence of adverse events. Diagnosis requires a comprehensive assessment of muscle mass, strength, and physical performance.

EXPERIMENTAL GERONTOLOGY (2021)

添加到收藏夹

Article Geriatrics & Gerontology

Amelioration of diabetes-induced inflammation mediated pyroptosis, sarcopenia, and adverse muscle remodelling by bone morphogenetic protein-7

Chandrakala Aluganti Narasimhulu et al.

Summary: This study reveals that cellular pyroptosis induced by high blood sugar and inflammation is a key mechanism in diabetic muscle dysfunction, with BMP-7 showing therapeutic potential. It provides new insights into the treatment of diabetic myopathy.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2021)

添加到收藏夹

Review Nutrition & Dietetics

Metabolic Syndrome and Sarcopenia

Hiroki Nishikawa et al.

Summary: Skeletal muscle plays a crucial role in insulin-induced glucose metabolism, with muscle loss and intramuscular fat accumulation closely linked. Skeletal muscle loss and fat accumulation are associated with various pathologies through factors such as oxidative stress, inflammatory cytokines, mitochondrial dysfunction, insulin resistance, and inactivity. The relationship between Metabolic Syndrome (Met-S) and sarcopenia is attracting attention, with persistent inflammation, fat deposition, and insulin resistance thought to play important roles in their association.

NUTRIENTS (2021)

添加到收藏夹

Review Immunology

Programmed Cell Death Pathways in the Pathogenesis of Idiopathic Inflammatory Myopathies

Jia Shi et al.

Summary: Research has shown that dysregulated cell death and impaired clearance of dead cells contribute to the pathogenesis of idiopathic inflammatory myopathy, leading to immune responses and tissue damages. This provides evidence for potential therapeutic targets in treating IIM.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Review Chemistry, Medicinal

Understanding of sarcopenia: from definition to therapeutic strategies

Jee Won Kim et al.

Summary: Sarcopenia, the gradual loss of skeletal muscle mass and function with aging, is a social burden due to healthcare costs in super-aging societies. Although research has identified various factors contributing to sarcopenia, effective treatment remains elusive.

ARCHIVES OF PHARMACAL RESEARCH (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Dieckol Attenuated Glucocorticoid-Induced Muscle Atrophy by Decreasing NLRP3 Inflammasome and Pyroptosis

Seyeon Oh et al.

Summary: The study revealed that dexamethasone may induce muscle inflammation and atrophy, while Ecklonia cava extract and dieckol can alleviate these effects by reducing inflammasome formation and pyroptosis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Cell Biology

Schisandrae chinensis Fructus Extract Ameliorates Muscle Atrophy in Streptozotocin-Induced Diabetic Mice by Downregulation of the CREB-KLF15 and Autophagy-Lysosomal Pathways

Ho-Jung Choi et al.

Summary: This study investigated the therapeutic effect of the ethanolic extract of Schisandrae chinensis Fructus (SFe) on muscle wasting in streptozotocin (STZ)-induced diabetic mice. The results showed that SFe administration ameliorated muscle wasting by decreasing protein degradation via downregulation of the CREB-KLF15-mediated UPS system and the p62/SQSTM1-mediated autophagy-lysosomal pathway, suggesting potential benefits for glucose metabolism.

CELLS (2021)

添加到收藏夹

Review Oncology

Ferroptosis, necroptosis, and pyroptosis in anticancer immunity

Rong Tang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Effect of Quercetin on Dexamethasone-Induced C2C12 Skeletal Muscle Cell Injury

Chun Chen et al.

MOLECULES (2020)

添加到收藏夹

Review Physiology

The ubiquitin-proteasome system in regulation of the skeletal muscle homeostasis and atrophy: from basic science to disorders

Yasuo Kitajima et al.

JOURNAL OF PHYSIOLOGICAL SCIENCES (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Water Extract of Lotus Leaf Alleviates Dexamethasone-Induced Muscle Atrophy via Regulating Protein Metabolism-Related Pathways in Mice

Sang Hee Park et al.

MOLECULES (2020)

添加到收藏夹

Article Medicine, General & Internal

Global estimates of the need for rehabilitation based on the Global Burden of Disease study 2019: a systematic analysis for the Global Burden of Disease Study 2019

Alarcos Cieza et al.

LANCET (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Role of Pyroptosis in Cardiovascular Diseases and its Therapeutic Implications

Cheng Zeng et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2019)

添加到收藏夹

Article Medicine, Research & Experimental

ERK1/2 signaling induces skeletal muscle slow fiber-type switching and reduces muscular dystrophy disease severity

Justin G. Boyer et al.

JCI INSIGHT (2019)

添加到收藏夹

Article Medicine, Research & Experimental

NF-κB-Gasdermin D (GSDMD) Axis Couples Oxidative Stress and NACHT, LRR and PYD Domains-Containing Protein 3 (NLRP3) Inflammasome-Mediated Cardiomyocyte Pyroptosis Following Myocardial Infarction

Qian Lei et al.

MEDICAL SCIENCE MONITOR (2018)

添加到收藏夹

Review Cell Biology

Gasdermins: Effectors of Pyroptosis

Stephen B. Kovacs et al.

TRENDS IN CELL BIOLOGY (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Myricetin improves endurance capacity and mitochondrial density by activating SIRT1 and PGC-1α

Hoe-Yune Jung et al.

SCIENTIFIC REPORTS (2017)

添加到收藏夹

Article Endocrinology & Metabolism

The NLRP3 inflammasome contributes to sarcopenia and lower muscle glycolytic potential in old mice

Marin Jane McBride et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Leucine alleviates dexamethasone-induced suppression of muscle protein synthesis via synergy involvement of mTOR and AMPK pathways

Xiao J. Wang et al.

BIOSCIENCE REPORTS (2016)

添加到收藏夹

Review Cell Biology

The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation

Deepika Sharma et al.

JOURNAL OF CELL BIOLOGY (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Pore-forming activity and structural autoinhibition of the gasdermin family

Jingjin Ding et al.

NATURE (2016)

添加到收藏夹

Review Endocrinology & Metabolism

Inflammation induced loss of skeletal muscle

Priya Londhe et al.

BONE (2015)

添加到收藏夹

Article Chemistry, Applied

Identification and antioxidant properties of polyphenols in lotus seed epicarp at different ripening stages

Ying Liu et al.

FOOD CHEMISTRY (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Inflammation and Pyroptosis Mediate Muscle Expansion in an Interleukin-1β (IL-1β)-dependent Manner

Subhash Haldar et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Analysis of Flavonoids in Lotus (Nelumbo nucifera) Leaves and Their Antioxidant Activity Using Macroporous Resin Chromatography Coupled with LC-MS/MS and Antioxidant Biochemical Assays

Ming-Zhi Zhu et al.

MOLECULES (2015)

添加到收藏夹

Review Biochemistry & Molecular Biology

Inflammasomes: mechanism of action, role in disease, and therapeutics

Haitao Guo et al.

NATURE MEDICINE (2015)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Muscle wasting in disease: molecular mechanisms and promising therapies

Shenhav Cohen et al.

NATURE REVIEWS DRUG DISCOVERY (2015)

添加到收藏夹

Review Pharmacology & Pharmacy

Skeletal muscle atrophy: Potential therapeutic agents and their mechanisms of action

Vikas Dutt et al.

PHARMACOLOGICAL RESEARCH (2015)

添加到收藏夹

Article Physiology

The regulation of muscle mass by endogenous glucocorticoids

Theodore P. Braun et al.

FRONTIERS IN PHYSIOLOGY (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Anti-Angiogenic Effect of Nelumbo nucifera Leaf Extracts in Human Umbilical Vein Endothelial Cells with Antioxidant Potential

Jong Suk Lee et al.

PLOS ONE (2015)

添加到收藏夹

Review Endocrinology & Metabolism

Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx/atrogin-1

Sue C. Bodine et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2014)

添加到收藏夹

Article Immunology

Mechanism of NLRP3 inflammasome activation

Fayyaz S. Sutterwala et al.

YEAR IN IMMUNOLOGY: MYELOID CELLS AND INFLAMMATION (2014)

添加到收藏夹

Article Cell Biology

Dexamethasone-induced autophagy mediates muscle atrophy through mitochondrial clearance

Rodrigo Troncoso et al.

CELL CYCLE (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

Activation of ERK by sodium tungstate induces protein synthesis and prevents protein degradation in rat L6 myotubes

Rafael Salto et al.

FEBS LETTERS (2014)

添加到收藏夹

Review Biochemistry & Molecular Biology

Interactions between Autophagy Receptors and Ubiquitin-like Proteins Form the Molecular Basis for Selective Autophagy

Vladimir Rogov et al.

MOLECULAR CELL (2014)

添加到收藏夹

Review Biochemistry & Molecular Biology

Mechanisms regulating skeletal muscle growth and atrophy

Stefano Schiaffino et al.

FEBS JOURNAL (2013)

添加到收藏夹

Review Biochemistry & Molecular Biology

Glucocorticoid-induced skeletal muscle atrophy

O. Schakman et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2013)

添加到收藏夹

Review Biochemistry & Molecular Biology

Protein breakdown in muscle wasting: Role of autophagy-lysosome and ubiquitin-proteasome

Marco Sandri

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2013)

添加到收藏夹

Article Physiology

Antibody-directed myostatin inhibition enhances muscle mass and function in tumor-bearing mice

Kate T. Murphy et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2011)

添加到收藏夹

Review Immunology

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

Beckley K. Davis et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 29 (2011)

添加到收藏夹

Article Public, Environmental & Occupational Health

Exercise, Body Composition, and Functional Ability A Randomized Controlled Trial

Wolfgang Kemmler et al.

AMERICAN JOURNAL OF PREVENTIVE MEDICINE (2010)

添加到收藏夹

Review Oncology

Autophagy: cellular and molecular mechanisms

Danielle Glick et al.

JOURNAL OF PATHOLOGY (2010)

添加到收藏夹

Article Endocrinology & Metabolism

Mechanisms of Muscle Atrophy Induced by Glucocorticoids

O. Schakman et al.

HORMONE RESEARCH (2009)

添加到收藏夹

Article Agriculture, Multidisciplinary

Antioxidative Effect and Active Components from Leaves of Lotus (Nelumbo nucifera)

Hong-Yu Lin et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2009)

添加到收藏夹

Review Microbiology

Pyroptosis: host cell death and inflammation

Tessa Bergsbaken et al.

NATURE REVIEWS MICROBIOLOGY (2009)

添加到收藏夹

Review Endocrinology & Metabolism

Mechanisms of glucocorticoid-induced myopathy

O. Schakman et al.

JOURNAL OF ENDOCRINOLOGY (2008)

添加到收藏夹

Review Genetics & Heredity

Nuclear factor-kappa B signaling in skeletal muscle atrophy

Hong Li et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2008)

添加到收藏夹

Article Biochemistry & Molecular Biology

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

Serhiy Pankiv et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

添加到收藏夹

Review Cell Biology

Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages

Susan L. Fink et al.

CELLULAR MICROBIOLOGY (2006)

添加到收藏夹

Article Medicine, Research & Experimental

Disruption of either the Nfkb1 or the Bcl3 gene inhibits skeletal muscle atrophy

RB Hunter et al.

JOURNAL OF CLINICAL INVESTIGATION (2004)

添加到收藏夹

Article Multidisciplinary Sciences

Identification of ubiquitin ligases required for skeletal muscle atrophy

SC Bodine et al.

SCIENCE (2001)

添加到收藏夹

The Inhibition of Autophagy and Pyroptosis by an Ethanol Extract of Nelumbo nucifera Leaf Contributes to the Amelioration of Dexamethasone-Induced Muscle Atrophy

相关参考文献

导出引文

分享论文