24,25-Dihydroxy Vitamin D and Vitamin D Metabolite Ratio as Biomarkers of Vitamin D in Chronic Kidney Disease

The appropriate management of vitamin D deficiency and hyperparathyroidism is essential to prevent metabolic bone disorder (MBD) and cardiovascular diseases in chronic kidney disease (CKD). Recently, the 24,25-dihydroxyvitamin D [24,25(OH)(2)D] and vitamin D metabolite ratio (VMR), i.e., the ratio of 24,25(OH)(2)D to 25-hydroxyvitamin D [25(OH)D], have emerged as biomarkers of vitamin D level. We analyzed the usefulness of vitamin D biomarkers for the evaluation of MBD in patients with CKD. We analyzed blood and urine samples from 208 outpatients with CKD stage G2-G5. 25(OH)D showed a poor correlation with the estimated glomerular filtration rate (eGFR). Conversely, the 24,25(OH)(2)D level and VMR were significantly correlated with eGFR and the intact parathyroid hormone level. In conclusion, 24,25(OH)(2)D and VMR have the potential to be vitamin D biomarkers for the detection of MBD in CKD patients.

Automated summary

Appropriate management of vitamin D deficiency and hyperparathyroidism is essential in preventing metabolic bone disorder and cardiovascular diseases in chronic kidney disease. The study found that the ratio of 24,25-dihydroxyvitamin D to 25-hydroxyvitamin D (VMR) can serve as a useful biomarker for evaluating metabolic bone disorder in CKD patients. The study concluded that 24,25-dihydroxyvitamin D and VMR have the potential to be reliable vitamin D biomarkers in CKD patients.