Association between Blood Manganese Levels and Visceral Adipose Tissue in the United States: A Population-Based Study

Article Biochemistry & Molecular Biology

Association Between Essential and Non-essential Metals, Body Composition, and Metabolic Syndrome in Adults

Yi Jing Ngu et al.

Summary: The study found that exposure to essential metals may affect body composition and metabolic profiles, exacerbating the risk of metabolic syndrome.

BIOLOGICAL TRACE ELEMENT RESEARCH (2022)

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Article Environmental Sciences

Clinical relevance of environmental manganese exposure with liver stiffness and steatosis detected by transient elastography in adults

Xiaohui Liu et al.

Summary: The study revealed that higher blood manganese concentrations were positively associated with liver stiffness and steatosis, primarily in females, in races other than Non-Hispanic White, and in obese subjects.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2022)

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Article Biochemistry & Molecular Biology

Manganese-Induced Oxidative Stress Contributes to Intestinal Lipid Deposition via the Deacetylation of PPAR gamma at K339 by SIRT1

Wu-Hong Lv et al.

Summary: High dietary Mn intake promotes lipid deposition in the intestine through the oxidative stress-SIRT1-PPARγ pathway.

ANTIOXIDANTS & REDOX SIGNALING (2022)

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Article Environmental Sciences

Non-linear associations between metabolic syndrome and four typical heavy metals: Data from NHANES 2011-2018

Jianli Zhou et al.

Summary: This study examines the associations between blood levels of typical heavy metals and metabolic syndrome (MetS) among adults. The findings suggest that higher levels of blood lead, cadmium, and mercury are associated with a lower risk of MetS, while higher levels of blood manganese are associated with a higher risk of MetS in the age group of 30-49 years. Non-linear associations between heavy metal levels and MetS risk were also observed.

CHEMOSPHERE (2022)

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Review Toxicology

The impact of environmental and occupational exposures of manganese on pulmonary, hepatic, and renal functions

Deepa Gandhi et al.

Summary: Manganese is an essential trace element for humans, but long-term exposures can lead to health issues, including multiple organ dysfunction. Studies support a causal link between Mn exposure and structural and functional changes in organs, with toxic mechanisms including altered cell activities, oxidative stress, and cell apoptosis. Treatment strategies and future research directions are also discussed.

JOURNAL OF APPLIED TOXICOLOGY (2022)

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Article Public, Environmental & Occupational Health

Assessment of causal effects of visceral adipose tissue on risk of cancers: a Mendelian randomization study

Yao Lu et al.

Summary: This study found that lifelong exposure to elevated volumes of visceral adipose tissue (VAT) might increase the risk of pancreatic cancer and lung squamous-cell carcinoma. These findings highlight the importance of revealing the underlying mechanisms for intervention targets.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2022)

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Article Water Resources

Exposure to a Mixture of Metals and Growth Indicators in 6-11-Year-Old Children from the 2013-2016 NHANES

Antonio J. Signes Pastor et al.

Summary: Metal co-exposures during childhood may influence children's body mass and linear growth indicators, and the relationships may vary depending on the exposure levels of the components of the metal mixture.

EXPOSURE AND HEALTH (2021)

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Article Endocrinology & Metabolism

DXA Measured Visceral Adipose Tissue, Total Fat, Anthropometric Indices and its Association With Cardiometabolic Risk Factors in Mother-Daughter Pairs From India

Sahana Shetty et al.

Summary: Visceral fat is associated with diabetes, dyslipidemia, and cardiovascular diseases, and increases with age and menopause. DXA-measured VAT is a better predictor of cardiometabolic risk factors in postmenopausal women. Total body fat may have a familial resemblance, but VAT is determined by age, menopause, and lifestyle factors.

JOURNAL OF CLINICAL DENSITOMETRY (2021)

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Article Environmental Sciences

Heat shock proteins took part in oxidative stress-mediated inflammatory injury via NF-κB pathway in excess manganese-treated chicken livers

Yuhao Liu et al.

Summary: This study aimed to investigate the mechanism of damage caused by excess Mn in chicken livers and found that Mn exposure led to inflammatory injury via NF-kappa B pathway. Additionally, Mn exposure induced oxidative stress and up-regulated HSPs expression, which mediated inflammatory damage. Time- and dose-dependent effects were observed on Mn-induced chicken liver inflammatory injury.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

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Article Endocrinology & Metabolism

Association of Usual Sodium Intake with Obesity Among US Children and Adolescents, NHANES 2009-2016

Lixia Zhao et al.

Summary: The study found that in the US, sodium intake was positively associated with overweight/obesity, obesity, and central obesity among children, independent of energy and sugar-sweetened beverage intake. However, this association did not reach significance among adolescents.

OBESITY (2021)

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Review Physiology

Effect of Exercise Training on Fat Loss-Energetic Perspectives and the Role of Improved Adipose Tissue Function and Body Fat Distribution

Kristoffer Jensen Kolnes et al.

Summary: Excessive abdominal fat in obesity increases the risk of metabolic disorders, and physical activity, particularly high-intensity interval training, is recommended for prevention and treatment. High-intensity exercise utilizes carbohydrates as the main energy source and can reduce fat mass despite lower fat oxidation levels.

FRONTIERS IN PHYSIOLOGY (2021)

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Article Engineering, Environmental

Machine-Learning Predictions of High Arsenic and High Manganese at Drinking Water Depths of the Glacial Aquifer System, Northern Continental United States

Melinda L. Erickson et al.

Summary: The study successfully predicted high arsenic and manganese concentrations in groundwater in the glacial aquifer system in the northern United States using machine learning models. By analyzing groundwater age metrics, redox conditions, and pH, the models were able to determine a high likelihood of high As and high Mn in the central part of the GLAC.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2021)

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Article Environmental Sciences

Chronic Manganese Exposure and the Enteric Nervous System: An in Vitro and Mouse in Vivo Study

Shivani Ghaisas et al.

Summary: Chronic environmental exposure to manganese can cause severe damage to the central nervous system, and its potential toxic effects on the enteric nervous system have yet to be assessed. The study found that Mn preferentially induced mitochondrial dysfunction in a rat EGC line and resulted in inflammation in the ENS in vivo.

ENVIRONMENTAL HEALTH PERSPECTIVES (2021)

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Article Medicine, General & Internal

Trends in Prevalence of Diabetes and Control of Risk Factors in Diabetes Among US Adults, 1999-2018

Li Wang et al.

Summary: The study based on NHANES data from US adults reveals a significant increase in the prevalence of diabetes between 1999-2000 and 2017-2018. Only around 21% of adults with diagnosed diabetes achieved all three risk factor control goals in 2015-2018.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Cardiac & Cardiovascular Systems

Management of Obesity in Cardiovascular Practice JACC Focus Seminar

Jean-Pierre Despres et al.

Summary: Obesity, linked to type 2 diabetes and cardiovascular disease, reduces life expectancy. It is a heterogeneous condition with different causes and health consequences. Attention should be focused on two prevalent subgroups: overweight/moderately obese individuals with excess visceral fat, and severely obese individuals with additional health issues related to their large body fat mass.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

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Article Environmental Sciences

Associations between blood and urinary manganese with metabolic syndrome and its components: Cross-sectional analysis of National Health and Nutrition Examination Survey 2011-2016

Kenneth Lo et al.

Summary: The study found a U-shaped relationship between urinary manganese levels and the prevalence of MetS, while blood manganese levels showed no significant association. Urinary manganese played a less important role in the development of MetS, with gender differences observed.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Article Environmental Sciences

Long-Term Ambient Air Pollution Exposures and Circulating and Stimulated Inflammatory Mediators in a Cohort of Midlife Adults

Sheila Tripathy et al.

Summary: Chronic exposure to air pollution may lead to increased production of inflammatory mediators by immune cells, but does not necessarily correlate with circulating markers of inflammation.

ENVIRONMENTAL HEALTH PERSPECTIVES (2021)

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Article Cell Biology

Dysregulation of TFEB contributes to manganese-induced autophagic failure and mitochondrial dysfunction in astrocytes

Ziyan Zhang et al.

AUTOPHAGY (2020)

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Article Otorhinolaryngology

Association of Subclinical Hearing Loss With Cognitive Performance

Justin S. Golub et al.

JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY (2020)

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Article Environmental Sciences

Associations between organophosphate esters and sex hormones among 6-19-year old children and adolescents in NHANES 2013-2014

Kai Luo et al.

ENVIRONMENT INTERNATIONAL (2020)

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Article Nutrition & Dietetics

Reference values of body composition parameters and visceral adipose tissue (VAT) by DXA in adults aged 18-81 years-results from the LEAD cohort

Alina Ofenheimer et al.

EUROPEAN JOURNAL OF CLINICAL NUTRITION (2020)

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Article Environmental Sciences

Manganese induces autophagy dysregulation: The role of S-nitrosylation in regulating autophagy related proteins in vivo and in vitro

Zhuo Ma et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2020)

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Article Microscopy

Induction of hepatic portal fibrosis, mitochondria damage, and extracellular vesicle formation in Sprague-Dawley rats exposed to copper, manganese, and mercury, alone and in combination

Priyanka Dhanraj et al.

ULTRASTRUCTURAL PATHOLOGY (2020)

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Article Medicine, General & Internal

Association of Low-Carbohydrate and Low-Fat Diets With Mortality Among US Adults

Zhilei Shan et al.

JAMA INTERNAL MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Redox toxicology of environmental chemicals causing oxidative stress

Fuli Zheng et al.

REDOX BIOLOGY (2020)

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Article Critical Care Medicine

Cross-Sectional Studies Strengths, Weaknesses, and Recommendations

Xiaofeng Wang et al.

CHEST (2020)

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Article Endocrinology & Metabolism

Causes, consequences, and treatment of metabolically unhealthy fat distribution

Norbert Stefan

Lancet Diabetes & Endocrinology (2020)

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Article Environmental Sciences

Association between exposure to a mixture of phenols, pesticides, and phthalates and obesity: Comparison of three statistical models

Yuqing Zhang et al.

ENVIRONMENT INTERNATIONAL (2019)

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Review Environmental Sciences

Statistical Methodology in Studies of Prenatal Exposure to Mixtures of Endocrine Disrupting Chemicals: A Review of Existing Approaches and New Alternatives

Nina Lazarevic et al.

ENVIRONMENTAL HEALTH PERSPECTIVES (2019)

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Article Respiratory System

Obesity alters oestrogen metabolism and contributes to pulmonary arterial hypertension

Kirsty M. Mair et al.

EUROPEAN RESPIRATORY JOURNAL (2019)

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Obesity: global epidemiology and pathogenesis

Matthias Blueher

NATURE REVIEWS ENDOCRINOLOGY (2019)

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Isocaloric Substitution of Dietary Carbohydrate Intake with Fat Intake and MRI-Determined Total Volumes of Visceral, Subcutaneous and Hepatic Fat Content in Middle-Aged Adults

Christa Meisinger et al.

NUTRIENTS (2019)

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Article Environmental Sciences

Manganese transporter genetics and sex modify the association between environmental manganese exposure and neurobehavioral outcomes in children

Karin Broberg et al.

ENVIRONMENT INTERNATIONAL (2019)

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Article Biochemistry & Molecular Biology

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Review Endocrinology & Metabolism

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Hongjuan Fang et al.

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2018)

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Article Endocrinology & Metabolism

Dietary manganese and type 2 diabetes mellitus: two prospective cohort studies in China

Shanshan Du et al.

DIABETOLOGIA (2018)

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Article Environmental Sciences

Airborne manganese exposure and neurobehavior in school-aged children living near a ferro-manganese alloy plant

Juliana L. G. Rodrigues et al.

ENVIRONMENTAL RESEARCH (2018)

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Review Medicine, Research & Experimental

Mitochondrial dysfunction in obesity

Aline Haas de Mello et al.

LIFE SCIENCES (2018)

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Effects of alternate-day fasting or daily calorie restriction on body composition, fat distribution, and circulating adipokines: Secondary analysis of a randomized controlled trial

John F. Trepanowski et al.

CLINICAL NUTRITION (2018)

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Article Pharmacology & Pharmacy

Manganese-induced sex-specific gut microbiome perturbations in C57BL/6 mice

Liang Chi et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2017)

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Article Nutrition & Dietetics

Dietary intake of manganese and the risk of the metabolic syndrome in a Chinese population

Biao Zhou et al.

BRITISH JOURNAL OF NUTRITION (2016)

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Exposure, epidemiology, and mechanism of the environmental toxicant manganese

Pan Chen et al.

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Article Environmental Sciences

Relationship between the Concentrations of Heavy Metals and Bioelements in Aging Men with Metabolic Syndrome

Iwona Rotter et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2015)

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Manganese concentrations in soil and settled dust in an area with historic ferroalloy production

Brian T. Pavilonis et al.

JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY (2015)

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Article Public, Environmental & Occupational Health

Climate change and the emergence of vector-borne diseases in Europe: case study of dengue fever

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BMC PUBLIC HEALTH (2014)

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Review Physiology

PATHOPHYSIOLOGY OF HUMAN VISCERAL OBESITY: AN UPDATE

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PHYSIOLOGICAL REVIEWS (2013)

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Article Pharmacology & Pharmacy

Manganese-induced apoptosis in hepatocytes after partial hepatectomy

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EUROPEAN JOURNAL OF PHARMACOLOGY (2005)

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Article Environmental Sciences

Effect of manganese chloride exposure on liver and brain mitochondria function in rats

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ENVIRONMENTAL RESEARCH (2003)

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Association between Blood Manganese Levels and Visceral Adipose Tissue in the United States: A Population-Based Study

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