期刊
NUTRIENTS
卷 14, 期 21, 页码 -出版社
MDPI
DOI: 10.3390/nu14214656
关键词
body weight; gut microbiota; inflammation; d-fagomine; iminosugar; iminocyclitol
资金
- Spanish Ministry of Economy, Industry, and Competitiveness [AGL2017-83599-R, PID2020-117009RB-I00]
- MEIC
- Centro de Excelencia Severo Ochoa
- CERCA Programme/Generalitat de Catalunya
This study investigated the effects of d-fagomine on gut microbiota, body weight, and inflammation markers in rats. The results showed that d-fagomine could reduce body weight gain, increase plasma acetate concentration, decrease pro-inflammatory biomarkers' concentrations, and induce changes in gut microbiota composition and diversity similar to dietary fiber.
The goal of this work is to explore if the changes induced by d-fagomine in the gut microbiota are compatible with its effect on body weight and inflammation markers in rats. Methods: Sprague Dawley rats were fed a standard diet supplemented with d-fagomine (or not, for comparison) for 6 months. The variables measured were body weight, plasma mediators of inflammation (hydroxyeicosatetraenoic acids, leukotriene B4, and IL-6), and the concentration of acetic acid in feces and plasma. The composition and diversities of microbiota in cecal content and feces were estimated using 16S rRNA metabarcoding and high-throughput sequencing. We found that after just 6 weeks of intake d-fagomine significantly reduced body weight gain, increased the plasma acetate concentration, and reduced the plasma concentration of the pro-inflammatory biomarkers' leukotriene B4, interleukin 6 and 12 hydroxyeicosatetraenoic acids. These changes were associated with a significantly increased prevalence of Bacteroides and Prevotella feces and increased Bacteroides, Prevotella, Clostridium, and Dysgonomonas while reducing Anaerofilum, Blautia, and Oribacterium in cecal content. In conclusion, d-fagomine induced changes in the composition and diversity of gut microbiota similar to those elicited by dietary fiber and compatible with its anti-inflammatory and body-weight-reducing effects.
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