期刊
NUTRIENTS
卷 14, 期 22, 页码 -出版社
MDPI
DOI: 10.3390/nu14224924
关键词
chia seed; western diet; intestinal microbiota; intestinal morphology; SCFA; intestinal functionality
资金
- Foundation for Research Support of Minas Gerais (FAPEMIG, Brazil) [APQ-02183-17]
- Coordination for the Improvement of Higher Education Personnel (CAPES, Brazil) [88887.599144/2021-00]
- National Counsel of Technological and Scientific Development (CNPq, Brazil) [406517/2018-5, 310910/2020-0]
- Foundation for Research an Innovation Support of Espirito Santo (FAPES, Brazil-PRONEX-CNPq/FAPES) [24/2018-TO 567/2018]
The consumption of chia flour was found to improve intestinal morphology and functionality in young Wistar rats, but did not significantly alter the intestinal microbiome in a short-term study period of 35 days.
A direct correlation has been reported between excessive fat intake and the development and progression of various enteropathies. Plant foods may contain bioactive compounds and non-digestible dietary fiber, with potential to improve intestinal health. Chia is a good source of dietary fiber and bioactive compounds. Our study evaluated the role of chia flour associated with a high-fat diet (HFD) on colon histomorphometry, intestinal functionality and intestinal microbiome composition and function in Wistar rats. The study used 32 young male rats separated into four groups to receive a standard diet (SD) or HFD, with or without chia, for 35 days. At the end of the study, the cecum, cecal content and duodenum were collected. The consumption of chia increased the production of short-chain fatty acids and improved fecal moisture. Chia consumption improved the circular muscle layer in the SD group. The diversity and abundance of intestinal bacteria were not affected, but increased richness was observed in the microbiome of the SD+chia group. Moreover, chia consumption decreased the expression of proteins involved in intestinal functionality. Chia consumption improved intestinal morphology and functionality in young Wistar rats but was insufficient to promote significant changes in the intestinal microbiome in a short term of 35 days.
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