4.7 Article

Proposal for a Standard Protocol to Assess the Rheological Behavior of Thickening Products for Oropharyngeal Dysphagia

期刊

NUTRIENTS
卷 14, 期 23, 页码 -

出版社

MDPI
DOI: 10.3390/nu14235028

关键词

rheology; viscosity; shear rate; amylase; dysphagia

资金

  1. Morinaga Milk Industry Co., Ltd.
  2. Fundacio Salut del Consorci Sanitari del Maresme
  3. Centro de Investigacion en Red en Enfermedades Hepaticas y Digestivas (CIBERehd)
  4. Instituto de Salud Carlos III
  5. Strategic Action on Oropharyngeal Dysphagia, Fondo de Investigaciones Sanitarias, Instituto de Salud Carlos III [EHD16PI02]
  6. Territorial Competitiveness Specialization Project (PECT) of Mataro-Maresme - Government of Catalunya-Generalitat de Catalunya [PI18/00241]

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A rheological protocol was designed and validated to accurately measure the shear viscosity of thickening products and assess the impact of oral and pharyngeal factors on therapeutic effect. The study showed that different laboratories can obtain similar and accurate measurements using this protocol.
Increasing shear viscosity (ShV) in thickening products (TP) is a valid therapeutic strategy for oropharyngeal dysphagia (OD). However, salivary amylase in the oral phase and shear rate in the pharyngeal phase of swallowing can change the viscosity of TPs when swallowed. This study aims to design and validate a rheological protocol to reproduce the oral and pharyngeal factors that affect the therapeutic effect of TPs and report the viscosity measurements in a standardized scientific and precise manner. We measured (a) the variability of the ShV measurements across several laboratories; (b) the in vitro and ex vivo properties of TPs and (c) the impact of the X-ray contrast Omnipaque, temperature and resting time on the rheological properties of TPs. A common protocol was applied in four international laboratories to assess five ShV values (100, 200, 400, 800 and 1600 mPa center dot s) for the xanthan-gum TP Tsururinko Quickly (TQ). The protocol included the dose (g/100 mL water), stirring procedure and standing time before measurement. Each value was characterized at the shear rate of 50 and 300 s(-1) pre- and post-oral incubation in eight volunteers. The effect of temperature, standing time and Omnipaque was assessed. The main results of the study were: (a) The mean intra-laboratory variability on the ShV at all levels was very low: 0.85%. The mean inter-laboratory variability was higher: 9.3%; (b) The shear thinning of TQ at 300 s(-1) was 75-80%. Increasing the temperature or standing time did not affect the ShV, and oral amylase caused a small decrease; (c) Omnipaque slightly decreased the dose of TP and hardly affected the amylase resistance or shear thinning. This study showed that different laboratories can obtain very accurate and similar ShV measurements using this protocol which uses scientific, universal SI units (mPa center dot s). Our protocol accurately reproduces oral and pharyngeal factors affecting the therapeutic effect of TPs. The addition of X-ray contrast did not produce significant changes.

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