Nutraceuticals as Potential Therapeutic Modulators in Immunometabolism

Review Biochemistry & Molecular Biology

NRF2 modulation in TRAMP mice: an in vivo model of prostate cancer

Daniela Marzioni et al.

Summary: This article reviews the role of natural and synthetic compounds in modulating the NRF2 pathway in the TRAMP mouse model, providing an overview of prostate carcinogenesis and its potential prevention.

MOLECULAR BIOLOGY REPORTS (2023)

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Review Immunology

Impact of intracellular innate immune receptors on immunometabolism

Wei-Chun Chou et al.

Summary: Immunometabolism plays a crucial role in regulating immune cell functions, with the interaction between PI3K-AKT-mTOR and LKB1-AMPK signaling pathways being essential for modulating cell metabolism. Intracellular innate immune sensors/receptors have a significant impact on metabolic pathways, highlighting the need for further investigation into their mechanisms of interaction.

CELLULAR & MOLECULAR IMMUNOLOGY (2022)

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Review Biochemistry & Molecular Biology

The Action of Vitamin D in Adipose Tissue: Is There the Link between Vitamin D Deficiency and Adipose Tissue-Related Metabolic Disorders?

Izabela Szymczak-Pajor et al.

Summary: Adipose tissue plays a crucial role in metabolism, while deficiency in vitamin D can disrupt its functioning. Restoring the proper functionality of adipose tissue is important in reducing the risk of obesity-related complications.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Immunology

Dynamic Number and Function of IL-10-Producing Regulatory B Cells in the Immune Microenvironment at Distinct Stages of Type 1 Diabetes

Ruimei Jiang et al.

Summary: The critical role of IL-10-producing B cells (B10 cells) in suppressing autoimmune responses and relieving inflammation has been demonstrated, but their regulatory role in type 1 diabetes is unclear. This study found that a defect in the number and function of B10 cells may contribute to the development and progression of type 1 diabetes.

JOURNAL OF IMMUNOLOGY (2022)

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Article Cell Biology

Acetyl-CoA carboxylase-1/2 blockade locks dendritic cells in the semimature state associated with FA deprivation by favoring FAO

Thuy Nguyen-Phuong et al.

Summary: Immunometabolism sheds light on the connection between immune cell function and metabolic processes, with fatty acid metabolism playing a vital role in dendritic cells (DCs). Blocking fatty acid synthesis in DCs switches their metabolism to fatty acid oxidation and affects their functional maturation. Targeting ACC1/2 could be a promising approach to control DC fate.

JOURNAL OF LEUKOCYTE BIOLOGY (2022)

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Review Biochemistry & Molecular Biology

Dendritic Cells and Their Immunotherapeutic Potential for Treating Type 1 Diabetes

Farhan Ullah Khan et al.

Summary: Type 1 diabetes is caused by the destruction of pancreatic beta cells mediated by T cells. Dendritic cells play a crucial role in the initiation and development of this disease by presenting antigens to activate and regulate the immune response. Recent advancements in understanding dendritic cell function and regulation have led to the development of potential therapeutic strategies for treating type 1 diabetes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Biochemistry & Molecular Biology

Nutraceutical Concepts and Dextrin-Based Delivery Systems

Gjylije Hoti et al.

Summary: Nutraceuticals are compounds with valuable biological activities and health-promoting effects. The usage of nutraceuticals is limited by various factors, which can be overcome by nanotechnology. The application of nanomaterials-based drug delivery systems, such as modified cyclodextrin-based nanosponges, can improve the solubility, stability, and bioavailability of nutraceuticals. This review highlights the potential of nanosystems based on linear dextrins for nutraceutical delivery.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Food Science & Technology

Butyrate Drives Metabolic Rewiring and Epigenetic Reprogramming in Human Colon Cancer Cells

Lujing Wang et al.

Summary: Butyrate regulates the expression of cancer markers through modulating CpG methylation, activates the mitochondrial TCA cycle, and inhibits methionine metabolism, thereby exerting cancer-preventive/anticancer effects in colorectal cancer cell model.

MOLECULAR NUTRITION & FOOD RESEARCH (2022)

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Article Nutrition & Dietetics

What Is the Current Direction of the Research on Carotenoids and Human Health? An Overview of Registered Clinical Trials

Daniela Martini et al.

Summary: Carotenoid research focuses on bioavailability, human health effects, eye and cardiovascular health, and recently on cognitive function and carotenoid-gut microbiota interactions. However, current research is still mostly focused on the bioavailability and metabolism of carotenoids, as well as the impact of food technologies and the development of new carotenoid formulations.

NUTRIENTS (2022)

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Article Immunology

Alcohol Impairs Immunometabolism and Promotes Naive T Cell Differentiation to Pro-Inflammatory Th1 CD4+ T Cells

Patrick M. McTernan et al.

Summary: This study found that ethanol disrupts CD4(+) T cell differentiation, increasing pro-inflammatory cells and decreasing immunosuppressive cells, as well as affecting CD4(+) T cell immunometabolism and impairing mitochondrial repair processes.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Immunology

FABP5 Deficiency Impaired Macrophage Inflammation by Regulating AMPK/NF-KB Signaling Pathway

Yangxiao Hou et al.

Summary: The study found that the deletion of FABP5 or supplementation of oleic acid can alleviate LPS-induced acute liver injury, possibly through increasing intracellular unsaturated fatty acids, activating AMPK, and inhibiting the NF-KB pathway in macrophages.

JOURNAL OF IMMUNOLOGY (2022)

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Article Cell Biology

Modulation of matrix metalloproteases by ciliary neurotrophic factor in human placental development

Giovanni Tossetta et al.

Summary: CNTF plays a role in regulating specific metalloproteases in placental cell proliferation and invasion.

CELL AND TISSUE RESEARCH (2022)

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Review Pharmacology & Pharmacy

Glucose-lowering effect of berberine on type 2 diabetes: A systematic review and meta-analysis

Wenting Xie et al.

Summary: Berberine has glucose-lowering effects in type 2 diabetes and its efficacy is related to the baseline fasting plasma glucose and glycosylated hemoglobin levels of patients. Treatment with berberine does not increase the risk of adverse events or hypoglycemia.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Immunology

Sulforaphane diminishes moonlighting of pyruvate kinase M2 and interleukin 1β expression in M1 (LPS) macrophages

Sheyda Bahiraii et al.

Summary: This study reveals that sulforaphane (Sfn) inhibits the expression of proinflammatory markers in M1 macrophages and enhances cellular energy levels. By impeding the function of pyruvate kinase M2 (PKM2), Sfn alters the glycolytic activity and IL-1β expression in macrophages, thus influencing the inflammatory response.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Biochemistry & Molecular Biology

Nutraceuticals: Focus on Anti-Inflammatory, Anti-Cancer, Antioxidant Properties in Gastrointestinal Tract

Giusy Rita Caponio et al.

Summary: Nutraceuticals have gained popularity due to their physiological and potential health effects. This review focuses on the major constituents of the Mediterranean diet and their effects on human health, specifically in the gastrointestinal tract. It provides a deeper understanding of nutraceuticals' therapeutic purpose and suggests personalized dietary components for adjuvant therapies.

ANTIOXIDANTS (2022)

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Review Nutrition & Dietetics

Curcuminoids for Metabolic Syndrome: Meta-Analysis Evidences Toward Personalized Prevention and Treatment Management

Agustina Dwi Retno Nurcahyanti et al.

Summary: Metabolic syndrome (MS) is a multifactorial syndrome associated with economic burden and healthcare costs, requiring multiple drug treatments that may have interactions and side effects. Therefore, developing new safe and effective drugs for MS is necessary.

FRONTIERS IN NUTRITION (2022)

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Article Biology

Anti-Inflammatory Effects of Cicadidae Periostracum Extract and Oleic Acid through Inhibiting Inflammatory Chemokines Using PCR Arrays in LPS-Induced Lung inflammation In Vitro

Jung-Hee Hong et al.

Summary: In this study, the anti-inflammatory effects and mechanisms of CP and OA treatments in LPS-stimulated lung epithelial cells were evaluated. The results showed that CP and OA significantly inhibited the expression of inflammatory mediators and exerted anti-inflammatory effects through the inhibition of multiple signaling pathways. These findings suggest that CP and OA have the potential to be therapeutic substances for treating lung and airway inflammation caused by allergic disorders.

LIFE-BASEL (2022)

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Article Biochemistry & Molecular Biology

Vitamin C enhances NF-κB-driven epigenomic reprogramming and boosts the immunogenic properties of dendritic cells

Octavio Morante-Palacios et al.

Summary: This study investigates the epigenomic and transcriptomic reprogramming induced by vitamin C in monocyte-derived dendritic cell (DC) differentiation and maturation. Vitamin C triggers extensive demethylation and upregulation of antigen-presentation and immune response-related genes during DC maturation. It also enhances TNF beta production in DCs and improves their ability to stimulate antigen-specific T cells.

NUCLEIC ACIDS RESEARCH (2022)

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Review Pharmacology & Pharmacy

Natural and synthetic compounds in Ovarian Cancer: A focus on NRF2/KEAP1 pathway

Giovanni Tossetta et al.

Summary: This review discusses the role of natural and synthetic compounds in modulating the NRF2/KEAP1 pathway in in vitro models of ovarian cancer and how these compounds can regulate chemotherapy response.

PHARMACOLOGICAL RESEARCH (2022)

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Article Microbiology

Oleic Acid and Palmitic Acid from Bacteroides thetaiotaomicron and Lactobacillus johnsonii Exhibit Anti-Inflammatory and Antifungal Properties

Rogatien Charlet et al.

Summary: This study investigates the effect of two fatty acids from Bacteroides thetaiotaomicron and Lactobacillus johnsonii on inflammation and fungal overgrowth in a murine model of colitis. The fatty acids were found to reduce proinflammatory mediators and increase anti-inflammatory markers in intestinal epithelial cells and macrophages. Oral administration of these fatty acids also reduced inflammatory parameters and eliminated Candida glabrata from the gut.

MICROORGANISMS (2022)

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Review Chemistry, Medicinal

Targeting immunometabolism by active ingredients derived from traditional Chinese medicines for treatment of rheumatoid arthritis

Yu-fei He et al.

Summary: Rheumatoid arthritis is a systemic autoimmune disease that mainly affects the synovium of joints, with metabolic misregulation being a fundamental pathogenesis and targeting immunometabolism as a new and effective approach to regulate immune responses. Natural active compounds from traditional Chinese medicines have potential therapeutic effects on RA and can regulate immunometabolism.

CHINESE HERBAL MEDICINES (2021)

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Review Nutrition & Dietetics

Polyphenols and Human Health: The Role of Bioavailability

Chiara Di Lorenzo et al.

Summary: Polyphenols are a group of phytochemicals with potential health-promoting effects, classified as flavonoid and non-flavonoid molecules. Their positive effects on health are influenced by factors affecting their bioavailability, and recent studies have shown that their metabolites may have beneficial properties.

NUTRIENTS (2021)

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Review Biochemistry & Molecular Biology

The Multifaced Actions of Curcumin in Pregnancy Outcome

Giovanni Tossetta et al.

Summary: Curcumin, a polyphenolic substance found in the rhizomes of Curcuma longa L, has various beneficial effects including anti-inflammatory, anti-oxidant properties. Studies have shown its potential use in managing pregnancy complications such as Preeclampsia, Gestational Diabetes Mellitus, and PreTerm Birth.

ANTIOXIDANTS (2021)

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Article Pharmacology & Pharmacy

Resveratrol suppresses the reprogramming of macrophages into an endotoxin-tolerant state through the activation of AMP-activated protein kinase

Hui Quan et al.

Summary: Resveratrol has beneficial effects on sepsis by regulating the inflammatory response, but its role in the development of endotoxin tolerance remains unclear. It has been found that resveratrol inhibits the expression of IRAK-M and SHIP1 through AMPK activation, suppressing the development of endotoxin tolerance.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

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Review Immunology

Autophagy in inflammation, infection, and immunometabolism

Vojo Deretic

Summary: Autophagy is a crucial cellular protection mechanism that impacts various diseases when disrupted, including infections, autoimmune diseases, and cancer. It plays a role in clearing harmful substances in and out of cells, protecting against inflammatory damage. The article focuses on the role of autophagy in inflammation, as well as its intersections with immunity, metabolism, and organelle functions.

IMMUNITY (2021)

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Review Nutrition & Dietetics

How Changes in the Nutritional Landscape Shape Gut Immunometabolism

Jian Tan et al.

Summary: Cell survival, proliferation, and function require energy from different metabolic pathways. Immune cells adapt their energy production to specific functions, affected by different metabolic pathways. Diet composition influences immune responses, particularly in the gut, where gut microbiota metabolites impact immune cell activity.

NUTRIENTS (2021)

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Article Pharmacology & Pharmacy

Intersection of immunometabolism and immunosenescence during aging

Kyoo-A Lee et al.

Summary: Aging is closely linked to chronic or metabolic diseases, and improving metabolic and immune function in the elderly can enhance quality of life and reduce the risk of other diseases. Inflammaging and metabolic dysfunction are key factors in the aging process, with age-related changes seen in immune cells and metabolic tissues. Promising gerotherapeutics aim to target nutrient and energy sensing, inflammatory pathways, and senescence, offering potential to improve healthspan and treat age-related diseases.

CURRENT OPINION IN PHARMACOLOGY (2021)

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Review Biochemistry & Molecular Biology

Nutraceuticals: Transformation of Conventional Foods into Health Promoters/Disease Preventers and Safety Considerations

Mudhi AlAli et al.

Summary: Nutraceuticals, essential food constituents with medicinal effects, have active compounds like carotenoids and collagen hydrolysate that positively impact cardiovascular and immune system health. Categorized based on nature and mode of action, they show potential therapeutic activities in disease prevention such as anti-cancer, antioxidant, anti-inflammatory, and anti-lipid effects. Research also covers mechanisms of action, safety for consumers, and future prospects in nutraceutical development.

MOLECULES (2021)

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Article Medicine, Research & Experimental

Gut-derived acetate promotes B10 cells with antiinflammatory effects

C. Daien et al.

Summary: Acetate has been shown to promote the differentiation of important immune cells B10 cells, both in mice and human blood cells, by increasing the production of acetylcoenzyme A and promoting posttranslational lysine acetylation. These effects contribute to maintaining immune balance and suggest that delivery of acetate, either directly or through dietary supplementation, could be a promising approach in restoring B10 cells in noncommunicable diseases.

JCI INSIGHT (2021)

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Article Cell Biology

SCFAs promote intestinal double-negative T cells to regulate the inflammatory response mediated by NLRP3 inflammasome

Shuiliang Ruan et al.

Aging-US (2021)

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Review Cell Biology

The emerging field of regulatory B cell immunometabolism

Elizabeth C. Rosser et al.

Summary: B cells are not only known for producing antibodies, but also for their anti-inflammatory properties. The signals determining whether B cells exert pro-inflammatory or anti-inflammatory functions are still not fully understood. Metabolic signals and tissue-specific signals play a pivotal role in controlling the balance between regulatory and antibody-producing B cell subsets.

CELL METABOLISM (2021)

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Review Biochemistry & Molecular Biology

The Immunometabolic Roles of Various Fatty Acids in Macrophages and Lymphocytes

Jose Cesar Rosa Neto et al.

Summary: Macrophages and lymphocytes exhibit metabolic plasticity, influenced by their activation state and the availability of energy substrates. Fatty acids play a crucial role in governing the phenotype, activation, and functional status of these cells.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Berberine, A Phytoalkaloid, Inhibits Inflammatory Response Induced by LPS through NF-Kappaβ Pathway: Possible Involvement of the IKKα

Kiran Kumar Reddi et al.

Summary: Berberine has been shown to possess therapeutic properties in various health conditions, including anti-inflammatory effects by inhibiting NF-kappa B translocation in activated monocytes. This suggests its potential for treating chronic inflammatory disorders.

MOLECULES (2021)

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Article Biochemistry & Molecular Biology

Nutraceuticals in Immune Function

Soo-Liang Ooi et al.

MOLECULES (2021)

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Review Nutrition & Dietetics

Beneficial Outcomes of Omega-6 and Omega-3 Polyunsaturated Fatty Acids on Human Health: An Update for 2021

Ivana Djuricic et al.

Summary: Oxidative stress and inflammation are important contributors to chronic non-communicable diseases. Different types of fatty acids have varying effects on chronic diseases, with moderate intake of Ω-6 fatty acids lowering the risk of cardiovascular diseases and Ω-3 fatty acids helping to reduce inflammation levels.

NUTRIENTS (2021)

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Review Cell Biology

Targeting immunometabolism as an anti-inflammatory strategy

Eva M. Palsson-McDermott et al.

CELL RESEARCH (2020)

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Article Food Science & Technology

Immune Th17 lymphocytes play a critical role in the multiple beneficial properties of resveratrol

Dominique Delmas et al.

FOOD AND CHEMICAL TOXICOLOGY (2020)

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Review Plant Sciences

Impact of natural products on the cholesterol transporter ABCA1

Dongdong Wang et al.

JOURNAL OF ETHNOPHARMACOLOGY (2020)

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Article Medicine, Research & Experimental

Oleic acid protects against cadmium induced cardiac and hepatic tissue injury in male Wistar rats: A mechanistic study

Bharati Bhattacharjee et al.

LIFE SCIENCES (2020)

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Article Agriculture, Dairy & Animal Science

Quercetin improves immune function in Arbor Acre broilers through activation of NF-κB signaling pathway

J. X. Yang et al.

POULTRY SCIENCE (2020)

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Review Nutrition & Dietetics

Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence

Anne-Laure Tardy et al.

NUTRIENTS (2020)

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Article Multidisciplinary Sciences

Resveratrol alleviates obesity-induced skeletal muscle inflammation via decreasing M1 macrophage polarization and increasing the regulatory T cell population

Maryam Shabani et al.

SCIENTIFIC REPORTS (2020)

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Review Cell Biology

Signaling networks in immunometabolism

Jordy Saravia et al.

CELL RESEARCH (2020)

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Editorial Material Immunology

Immunometabolism: From basic mechanisms to translation INTRODUCTION

Liza Makowski et al.

IMMUNOLOGICAL REVIEWS (2020)

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Article Endocrinology & Metabolism

Aerobic exercise and nano-curcumin supplementation improve inflammation in elderly females with metabolic syndrome

Ali Osali

DIABETOLOGY & METABOLIC SYNDROME (2020)

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Review Nutrition & Dietetics

Breast Cancer Prevention-Is there a Future for Sulforaphane and Its Analogs?

Dominika Kuran et al.

NUTRIENTS (2020)

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Article Immunology

Reformulating Small Molecules for Cardiovascular Disease Immune Intervention: Low-Dose Combined Vitamin D/Dexamethasone Promotes IL-10 Production and Atheroprotection in Dyslipidemic Mice

Laura Ospina-Quintero et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Immunology

The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System

Gholamreza Daryabor et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Multidisciplinary Sciences

Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate

Jack A. Bibby et al.

NATURE COMMUNICATIONS (2020)

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Article Endocrinology & Metabolism

Piperine ameliorates insulin resistance via inhibiting metabolic inflammation in monosodium glutamate-treated obese mice

Chaolong Liu et al.

BMC ENDOCRINE DISORDERS (2020)

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Article Veterinary Sciences

Anti-inflammatory effect of sulforaphane on BPS-stimulated RAW 264.7 cells and ob/ob mice

Sachithra S. Ranaweera et al.

JOURNAL OF VETERINARY SCIENCE (2020)

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Review Oncology

Anticancer Effects of Nutraceuticals in the Mediterranean Diet: An Epigenetic Diet Model

Rosa Divella et al.

CANCER GENOMICS & PROTEOMICS (2020)

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Review Endocrinology & Metabolism

The Interconnection Between Immuno-Metabolism, Diabetes, and CKD

Fabrizia Bonacina et al.

CURRENT DIABETES REPORTS (2019)

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Review Immunology

Regulation of metabolic supply and demand during B cell activation and subsequent differentiation

Takeshi Egawa et al.

CURRENT OPINION IN IMMUNOLOGY (2019)

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Review Cell Biology

The Use of Nutraceuticals to Counteract Atherosclerosis: The Role of the Notch Pathway

Giorgio Aquila et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

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Review Nutrition & Dietetics

Influence of Resveratrol on the Immune Response

Lucia Malaguarnera

NUTRIENTS (2019)

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Article Cell Biology

Keap1-Nrf2 System Plays an Important Role in Invariant Natural Killer T Cell Development and Homeostasis

Kalyani Pyaram et al.

CELL REPORTS (2019)

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Review Biotechnology & Applied Microbiology

Targeting metabolism to regulate immune responses in autoimmunity and cancer

Chirag H. Patel et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

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Review Immunology

Metabolic Control of Dendritic Cell Functions: Digesting Information

Stefanie K. Wculek et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Immunology

The Metabolic Signature of Macrophage Responses

Antonella Viola et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Integrative & Complementary Medicine

Inhibitory effects of berberine on proinflammatory M1 macrophage polarization through interfering with the interaction between TLR4 and MyD88

Jing Gong et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2019)

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Article Endocrinology & Metabolism

Naringenin improves insulin sensitivity in gestational diabetes mellitus mice through AMPK

Sen Li et al.

NUTRITION & DIABETES (2019)

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Article Immunology

Adiponectin Limits IFN-γ and IL-17 Producing CD4 T Cells in Obesity by Restraining Cell Intrinsic Glycolysis

Jayagopi Surendar et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Endocrinology & Metabolism

Biological Effects of Ciliary Neurotrophic Factor on hMADS Adipocytes

Jessica Perugini et al.

FRONTIERS IN ENDOCRINOLOGY (2019)

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Article Biochemistry & Molecular Biology

Regulatory role of vitamin E in the immune system and inflammation

Erin Diane Lewis et al.

IUBMB LIFE (2019)

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Review Chemistry, Medicinal

Isothiocyanate from Broccoli, Sulforaphane, and Its Properties

Alena Vanduchova et al.

JOURNAL OF MEDICINAL FOOD (2019)

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Article Biochemistry & Molecular Biology

Vitamin D controls the capacity of human dendritic cells to induce functional regulatory T cells by regulation of glucose metabolism

An-Sofie Vanherwegen et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2019)

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Review Immunology

An update on immune dysregulation in obesity-related insulin resistance

Gholamreza Daryabor et al.

SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2019)

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Review Immunology

Metabolic Checkpoints in Differentiation of Helper T Cells in Tissue Inflammation

Suyasha Roy et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Immunology

Plant-Derived Polyphenols Modulate Human Dendritic Cell Metabolism and Immune Function via AMPK-Dependent Induction of Heme Oxygenase-1

Nicole K. Campbell et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Immunology

Immunomodulatory Effects of Flavonoids: Possible Induction of T CD4+Regulatory Cells Through Suppression of mTOR Pathway Signaling Activity

Aysooda Hosseinzade et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Nutrition & Dietetics

Metabolism of Dietary and Microbial Vitamin B Family in the Regulation of Host Immunity

Ken Yoshii et al.

FRONTIERS IN NUTRITION (2019)

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Article Medicine, Research & Experimental

Grapefruit Flavonoid Naringenin Regulates the Expression of LXRα in THP-1 Macrophages by Modulating AMP-Activated Protein Kinase

Javier Saenz et al.

MOLECULAR PHARMACEUTICS (2018)

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Article Biotechnology & Applied Microbiology

Development and optimization of sulforaphane-loaded nanostructured lipid carriers by the Box-Behnken design for improved oral efficacy against cancer: in vitro, ex vivo and in vivo assessments

Kriti Soni et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2018)

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Review Biochemistry & Molecular Biology

Epigenetics and Immunometabolism in Diabetes and Aging

Tomasz J. Guzik et al.

ANTIOXIDANTS & REDOX SIGNALING (2018)

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Review Biochemistry & Molecular Biology

An Integrated View of Immunometabolism

Yun Sok Lee et al.

CELL (2018)

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Article Cell Biology

Metabolic regulation of macrophages in tissues

Jan Van den Bossche et al.

CELLULAR IMMUNOLOGY (2018)

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Article Biochemistry & Molecular Biology

Curcumin enhances LXRα in an AMP-activated protein kinase-dependent manner in human macrophages

Javier Saenz et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2018)

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Article Surgery

Tissue-Specific Phenotype and Activation of iNKT Cells in Morbidly Obese Subjects: Interaction with Adipocytes and Effect of Bariatric Surgery

Soledad Lopez et al.

OBESITY SURGERY (2018)

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Review Immunology

Metabolic Links between Plasma Cell Survival, Secretion, and Stress

Wing Y. Lam et al.

TRENDS IN IMMUNOLOGY (2018)

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Review Immunology

Influence of Inflammation in the Process of T Lymphocyte Differentiation: Proliferative, Metabolic, and Oxidative Changes

Marco A. Moro-Garcia et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Immunology

Parallels in immunometabolic Adipose Tissue Dysfunction with Ageing and Obesity

William Trim et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Immunology

Immunometabolic Activation of Invariant Natural Killer T Cells

Francesca A. Ververs et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Cell Biology

Short-Chain Fatty Acids Manifest Stimulative and Protective Effects on Intestinal Barrier Function Through the Inhibition of NLRP3 Inflammasome and Autophagy

Yanhai Feng et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

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Review Nutrition & Dietetics

Meta-analysis of randomized controlled trials of 4 weeks or longer suggest that curcumin may afford some protection against oxidative stress

Si Qin et al.

NUTRITION RESEARCH (2018)

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Article Immunology

Naive CD8+ T-Cells Engage a Versatile Metabolic Program Upon Activation in Humans and Differ Energetically From Memory CD8+ T-Cells

Francesco Nicoli et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Cell Biology

mTOR Regulation of Glycolytic Metabolism in T Cells

Robert J. Salmond

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2018)

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Review Pharmacology & Pharmacy

Defining 'nutraceuticals': neither nutritious nor pharmaceutical

Jeffrey K. Aronson

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2017)

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Article Food Science & Technology

Piperine inhibits ABCA1 degradation and promotes cholesterol efflux from THP-1-derived macrophages

Limei Wang et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2017)

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Review Immunology

Metabolic Regulation of the Immune Humoral Response

Mark Boothby et al.

IMMUNITY (2017)

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Review Cell Biology

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Age-associated decline in effective immune synapse formation of CD4+ T cells is reversed by vitamin E supplementation

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Inhibition of NF-κB and oxidative pathways in human dendritic cells by antioxidative vitamins generates regulatory T cells

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Simultaneous induction of CD4 T cell tolerance and CD8 T cell immunity by semimature dendritic cells

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Nutraceuticals as Potential Therapeutic Modulators in Immunometabolism

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