期刊
JOURNAL OF PHYSICS-CONDENSED MATTER
卷 28, 期 18, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/0953-8984/28/18/183001
关键词
nanotopography; cell adhesion; cell alignment; neurite guidance; hierarchical
资金
- National Research Foundation
- Mechanobiology Institute, Singapore - National Research Foundation Singapore
- Ministry of Education Singapore
- Prime Minister's Office, Singapore under its Research Centre of Excellence programme
Topography, among other physical factors such as substrate stiffness and extracellular forces, is known to have a great influence on cell behaviours. Optimization of topographical features, in particular topographical dimensions ranging from nanoscale to microscale, is the key strategy to obtain the best cellular performance for various applications in tissue engineering and regenerative medicine. In this review, we provide a comprehensive survey on the significance of sizes of topography and their impacts on cell adhesion, morphology and alignment, and neurite guidance. Also recent works mimicking the hierarchical structure of natural extracellular matrix by combining both nanoscale and microscale topographies are highlighted.
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