Local Circuits in the Cerebellum Interact with Biochemical Events

Article Psychology, Clinical

Abnormal dynamic functional connectivity of hippocampal subregions associated with working memory impairment in melancholic depression

Lai Shunkai et al.

Summary: Our study revealed decreased dFC variability between the left rostral hippocampus and left anterior lobe of cerebellum in patients with melancholic MDD, as well as poorer cognitive performance in various domains. Working memory was found to be positively correlated with the dFC variability between the left rostral hippocampus and left anterior lobe of cerebellum in this patient population.

PSYCHOLOGICAL MEDICINE (2023)

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Article Biochemistry & Molecular Biology

BOD1 regulates the cerebellar IV/V lobe-fastigial nucleus circuit associated with motor coordination

Xiu-Xiu Liu et al.

Summary: This study reveals a novel circuit in the cerebellum that regulates sensorimotor coordination. The role of BOD1 in this circuit is validated through experiments in mice. These findings provide potential neuromodulatory targets for the treatment of ataxia.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Article Neurosciences

Distinct Fastigial Output Channels and Their Impact on Temporal Lobe Seizures

Martha L. Streng et al.

Summary: The study reveals that specific cerebellar output channels, especially those targeting the central lateral thalamus, are crucial for controlling seizures in the hippocampus. This has important implications for therapeutic interventions.

JOURNAL OF NEUROSCIENCE (2021)

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Article Neurosciences

Functional Convergence of Motor and Social Processes in Lobule IV/V of the Mouse Cerebellum

Owen Y. Chao et al.

Summary: Disruption of activity in the major anterior lobule IV/V in mice impaired motor coordination but not general locomotion or anxiety-related behavior. Lesioned animals showed memory deficits, while chemogenetic excitation of Purkinje cells affected social approach and social memory.

CEREBELLUM (2021)

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Article Neurosciences

Catecholaminergic Innervation of the Lateral Nucleus of the Cerebellum Modulates Cognitive Behaviors

Erik S. Carlson et al.

Summary: The study reveals that cerebellar catecholamines play a role in cognitive behaviors, particularly in the lateral cerebellar nucleus (LCN). Norepinephrine is the major catecholamine in LCN, originating from locus coeruleus and a subset of Purkinje cells positive for TH staining. Deletion of TH in fibers innervating LCN results in impairments in sensorimotor integration, associative fear learning, response inhibition, and working memory.

JOURNAL OF NEUROSCIENCE (2021)

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Article Biology