期刊
MATERIALS
卷 15, 期 22, 页码 -出版社
MDPI
DOI: 10.3390/ma15228080
关键词
surface functionalisation; nano-coating; glass-ceramics; porous scaffold; bone regeneration
类别
资金
- EPSRC [EP/R51309X/1]
Bioceramic scaffolds were coated with gelatin and chondroitin sulphate via Layer-by-Layer assembly, resulting in enhanced cell behavior including adhesion, proliferation, and osteogenic activity.
Bioceramic scaffolds, composed of a biphasic composite containing bioactive glass and hydroxyapatite, were prepared in this work to overcome the intrinsic limits of the two components taken separately (in particular, their specific reactivities and dissolution rates, which should be tunable as a function of the given clinical requirements). To mimic the biological environment and tune the different stages of cellular response, a coating with gelatin and chondroitin sulphate via Layer-by-Layer (LbL) assembly was presented and discussed. The resulting functionalized scaffolds were affected by the coating in terms of microstructure and porosity. In addition, the LbL coating significantly enhanced the seeded cell behaviour, with high adhesion, proliferation and osteogenic activity, as revealed by the alkaline phosphatase activity and overexpression of osteopontin and osteocalcin.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据