Synthesis of Hollow Calcium Carbonate Microspheres by a Template Method for DOX Loading and Release with Carbon Dots Photosensitivity

Article Engineering, Biomedical

Tumor microenvironment pH-responsive pentagonal gold prism-based nanoplatform for multimodal imaging and combined therapy of castration-resistant prostate cancer

Haisong Tan et al.

Summary: A multifunctional nanoplatform was designed for delivering agents into the tumor microenvironment, achieving synergistic photothermal therapy/photodynamic therapy/chemical therapy, with tumor-targeting capacity and biocompatibility.

ACTA BIOMATERIALIA (2022)

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Article Chemistry, Physical

Dopamine- and citrate-mediated, rapid synthesis of hollow calcium carbonate nanoparticles: Their formation, metastability and transformation

Andan Zheng et al.

Summary: We developed a template-free approach for rapid fabrication of hollow CaCO3-based nanocarriers via dual-additive mediated crystallization. The combined additives of dopamine and citrate exert synergistic effects on hollow structure formation, stability, and oriented crystallization, providing deeper insights into additive-mediated crystallization pathway. This research may offer new opportunities for designing CaCO3-based materials with controllable morphology and crystal polymorphs.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2022)

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Article Engineering, Biomedical

Synthesis of enzyme-responsive theranostic amphiphilic conjugated bottlebrush copolymers for enhanced anticancer drug delivery

Fangjun Liu et al.

Summary: The synthesis of PF-based theranostic amphiphilic copolymers with high drug loading efficiency and tumor microenvironment-specific responsiveness for enhanced cancer therapy has been rarely reported. In this study, enzyme-responsive theranostic amphiphilic bottlebrush copolymers were successfully prepared, showing high drug loading efficiency and tumor microenvironment-specific responsiveness. The study developed a universal strategy for the construction of multifunctional polymeric vehicles based on PF and degradable polypeptide, and emphasized the better stability of micelles endowed by the branched hydrophilic brushes.

ACTA BIOMATERIALIA (2022)

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Article Engineering, Environmental

pH-responsive nanomedicine co-encapsulated with Erlotinib and chlorin e6 can enable effective treatment of triple negative breast cancer via reprogramming tumor vasculature

Yan Liu et al.

Summary: This study developed a pH-responsive nanomedicine that inhibits EGFR and normalizes tumor vasculature, improving tumor oxygenation and reducing tumor growth. It demonstrated the therapeutic efficacy of combined chemotherapy and photodynamic therapy in TNBC models, offering a potential treatment advantage for TNBC patients.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Chemistry, Applied

Biocompatible acid-degradable micro-mesoporous CaCO3:Si:Fe nanoparticles potential for drug delivery

Daniil A. Eurov et al.

Summary: Calcium carbonate nanoparticles with small size and porous structure were synthesized using a template method, and were additionally doped with Si and Fe for stabilizing aqueous suspension and enhancing cellular uptake. The nanoparticles were shown to dissolve completely in dilute HCl and possess high adsorption capacity for loading the anti-cancer drug doxorubicin. Encapsulation of the drug in the nanoparticles reduced its toxicity and increased its intracellular accumulation.

MICROPOROUS AND MESOPOROUS MATERIALS (2022)

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Article Chemistry, Multidisciplinary

Industrially synthesized biosafe vaterite hollow CaCO3 for controllable delivery of anticancer drugs

Zongqi Feng et al.

Summary: This study successfully developed an industrialized method for synthesizing high drug-loaded vaterite hollow calcium carbonate, showing promising applications in tumor therapy.

MATERIALS TODAY CHEMISTRY (2022)

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Review Chemistry, Multidisciplinary

Preparation and application of pH-responsive drug delivery systems

Haitao Ding et al.

Summary: Microenvironment-responsive drug delivery systems (DDSs) achieve targeted drug delivery and improve drug efficacy by responding to specific pH conditions in diseased tissues. Various synthetic approaches have been developed to prepare pH-sensitive DDSs, including the introduction of pH-sensitive chemical bonds or groups. Different nano DDSs, such as liposomes, micelles, hydrogels, dendritic macromolecules, and organic-inorganic hybrid nanoparticles, can respond to pH variations. These pH-sensitive DDSs have been applied in research on anticancer therapy and the diagnosis of cancer, inflammation, antibacterial infection, and neurological diseases.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Nanoscience & Nanotechnology

Smart Thermoresponsive Electrospun Nanofibers with On-Demand Release of Carbon Quantum Dots for Cellular Uptake

Bhaskarchand Gautam et al.

Summary: This paper presents a thermoresponsive carbon quantum dot-loaded blend nanofiber sheet for on-demand delivery of organic, inorganic, and biological cargo in vitro cellular uptake. The nanofiber sheet can effectively improve the cellular uptake of cargo by increasing the local concentrations via applying thermal stimulation as the released mechanism.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Chemistry, Multidisciplinary

Green Synthesis of Near-Infrared Copper-Doped Carbon Dots from Alcea for Cancer Photothermal Therapy

Meysam Najaflu et al.

Summary: This study developed an eco-friendly, simple, cost-efficient method to synthesize carbon dots with optical absorbance in the near-infrared region. The carbon dots showed potential for selective cancer photothermal therapy.

ACS OMEGA (2022)

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Article Chemistry, Physical

Optically induced insulator-to-semiconductor transition in fluorescent carbon quantum dots measured by terahertz time-domain spectroscopy

Dan Song et al.

Summary: This study examines the optoelectronic properties of dry fluorescent carbon quantum dots (FCQDs) using terahertz (THz) time-domain spectroscopy (TDS), revealing different behaviors of blue (B-CQDs) and red (R-CQDs) FCQDs in the THz range. This is the first research to apply THz TDS to dry CQDs, providing valuable insights into the physical properties of dry FCQDs.

CARBON (2021)

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Article Chemistry, Physical

Duplex metal co-doped carbon quantum dots-based drug delivery system with intelligent adjustable size as adjuvant for synergistic cancer therapy

Chuyi Han et al.

Summary: Carbon quantum dots (CQDs) are utilized for bioimaging due to their photoluminescence properties, and a new CQDs-based drug delivery system (Arg-Ag@Cu) was developed for targeted drug delivery and tumor theranostics with synergistic effects. The system involves metal co-doping, retention ability, gas-involving therapy, chemodynamic therapy, and photodynamic therapy, demonstrating potential in nanotheranostics.

CARBON (2021)

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Article Medicine, Research & Experimental

Molecular Dynamics Simulations of the pH-Dependent Adsorption of Doxorubicin on Carbon Quantum Dots

Pawel Wolski

Summary: The research investigated the combined effect of the amount of oxygen-containing groups on the carbon quantum dot surface and the pH level on the interaction mechanism between an anticancer drug and a carrier. The study found that the strength of interaction between CQDs and DOX increases with surface coverage and pH, with electrostatic interactions playing a significant role in drug loading. Molecular dynamics simulations provided a microscopic view of DOX loading and release on/from CQDs, which is crucial for the development of advanced CQD-based targeted drug delivery systems.

MOLECULAR PHARMACEUTICS (2021)

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Article Biophysics

Synthesis and characterization of porous CaCO3 microspheres templated by yeast cells and the application as pH value-sensitive anticancer drug carrier

Yan Wei et al.

Summary: Using Layer-by-Layer self-assembly method, porous calcium carbonate hybrid microspheres (CaCO3-HMPs) were prepared on yeast cells, demonstrating nearly spherical shape with visible pores and good drug release properties. The study indicates the promising application prospects of CaCO3-HMPs as anticancer drug carriers.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

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Article Engineering, Biomedical

Shape switching of CaCO3-templated nanorods into stiffness-adjustable nanocapsules to promote efficient drug delivery

Yuan Liu et al.

Summary: The study highlights the significance of shape and stiffness in designing nanocarriers for drug delivery, with different factors affecting blood circulation, tumor tissue accumulation, cellular internalization, and drug accumulation. Shape-shiftable nanocarriers show promising potential in addressing multiple delivery barriers for chemotherapeutic agents.

ACTA BIOMATERIALIA (2021)

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Article Chemistry, Multidisciplinary

Urchin-like Hydroxyapatite/Graphene Hollow Microspheres as pH-Responsive Bone Drug Carriers

Jie Li et al.

Summary: In this study, sea urchin-like rGO-TEPA/HA hollow microspheres were prepared via microwave hydrothermal synthesis, showing promising applications as bone drug carriers based on their noncytotoxicity in vitro experiments.

LANGMUIR (2021)

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Article Engineering, Environmental

Glutathione-activated DNA-Au nanomachine as targeted drug delivery platform for imaging-guided combinational cancer therapy

Kaixin Yu et al.

Summary: The development of a multifunctional DNA-Au nanomachine in this study enables targeted cancer cell recognition and delivery of anti-cancer drugs, achieving efficient combination therapy for breast cancer.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Materials Science, Multidisciplinary

Biomineralization inspired synthesis of CaCO3-based DDS for pH-responsive release of anticancer drug

Tingyu Yang et al.

Summary: Calcium carbonate is a promising candidate for cancer drug delivery systems due to its biocompatibility and low toxicity. A green biomineralization method using L-lysine was developed for the rapid preparation of CaCO3-based DDS with controlled morphology. Different crystal forms of CaCO3 microspheres showed varying drug loading capacity and pH-sensitivity.

MATERIALS TODAY COMMUNICATIONS (2021)

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Article Nanoscience & Nanotechnology

None-Loss Target Release of Biomimetic CaCO3 Nanocomposites for Screening Bioactive Components and Target Proteins

Yingying Tang et al.

Summary: The study successfully screened seven potential bioactive molecules from Tripterygium wilfordii using a biomimetic CaCO3 nanocomposite, with celastrol exhibiting the strongest anticancer activity. By capturing target proteins, 39 potential target proteins were identified and further confirmed the effect of celastrol on key proteins such as P53 and MDM2, exploring its antitumor mechanism.

ACS APPLIED BIO MATERIALS (2021)

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Article Chemistry, Physical