期刊
MATERIALS
卷 15, 期 24, 页码 -出版社
MDPI
DOI: 10.3390/ma15249030
关键词
polycaprolactone; graphene; 3D fabrication; fused deposition modelling; bioactivity; electroactivity
This study successfully developed PCL scaffolds with graphene using 3D fabrication technology, and comprehensively characterized their properties. The addition of graphene was found to improve the hydrophilicity, bioactivity, and electroactivity of the scaffolds, with 1.5% and 3% graphene concentrations showing the most significant increase in cell proliferation.
Polycaprolactone (PCL) is a well-established biomaterial, offering extensive mechanical attributes along with low cost, biocompatibility, and biodegradability; however, it lacks hydrophilicity, bioactivity, and electrical conductivity. Advances in 3D fabrication technologies allow for these sought-after attributes to be incorporated into the scaffolds during fabrication. In this study, solvent-free Fused Deposition Modelling was employed to fabricate 3D scaffolds from PCL with increasing amounts of graphene (G), in the concentrations of 0.75, 1.5, 3, and 6% (w/w). The PCL+G scaffolds created were characterised physico-chemically, electrically, and biologically. Raman spectroscopy demonstrated that the scaffold outer surface contained both PCL and G, with the G component relatively uniformly distributed. Water contact angle measurement demonstrated that as the amount of G in the scaffold increases (0.75-6% w/w), hydrophobicity decreases; mean contact angle for pure PCL was recorded as 107.22 +/- 9.39 degrees, and that with 6% G (PCL+6G) as 77.56 +/- 6.75 degrees. Electrochemical Impedance Spectroscopy demonstrated a marked increase in electroactivity potential with increasing G concentration. Cell viability results indicated that even the smallest addition of G (0.75%) resulted in a significant improvement in electroactivity potential and bioactivity compared with that for pure PCL, with 1.5 and 3% exhibiting the highest statistically significant increases in cell proliferation.
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