NUF2 promotes tumorigenesis by interacting with HNRNPA2B1 via PI3K/AKT/mTOR pathway in ovarian cancer

Article Oncology

PGC1α/β Expression Predicts Therapeutic Response to Oxidative Phosphorylation Inhibition in Ovarian Cancer

Carmen Ghilardi et al.

Summary: Inhibition of OXPHOS can control the progression of ovarian cancer, and high expression of PGC1α/β is correlated with this benefit, providing a potential biomarker for patient selection in this therapy.

CANCER RESEARCH (2022)

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Article Cell Biology

Global characterization of extrachromosomal circular DNAs in advanced high grade serous ovarian cancer

Yixuan Cen et al.

Summary: This study explored the characteristics of extrachromosomal circular DNAs (eccDNAs) in high grade serous ovarian cancer (HGSOC) and identified DNMT1(circle10302690-10302961) as the most significantly down-regulated eccDNA in metastatic tumors of HGSOC. The lower expression of DNMT1(circle10302690-10302961) was associated with worse prognosis of HGSOC.

CELL DEATH & DISEASE (2022)

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Article Oncology

Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma

Chen Huang et al.

Summary: This study presents a proteogenomic analysis of HPV-negative HNSCCs, identifying potential therapeutic targets and uncovering tumor characteristics such as immune status and resistance mechanisms. The findings suggest new strategies for stratifying HNSCC and improving treatment outcomes.

CANCER CELL (2021)

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Article Oncology

Correlation of NUF2 Overexpression with Poorer Patient Survival in Multiple Cancers

Xiaodan Jiang et al.

Summary: NUF2 is up-regulated in multiple cancers and is closely associated with tumor development and patient survival, particularly evident in hepatocellular carcinoma. The up-regulation of NUF2 plays a significant role in tumor growth and invasion.

CANCER RESEARCH AND TREATMENT (2021)

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Article Cell Biology

LncRNA CDKN2B-AS1 stabilized by IGF2BP3 drives the malignancy of renal clear cell carcinoma through epigenetically activating NUF2 transcription

Xina Xie et al.

Summary: The overexpression of CDKN2B-AS1 in KIRC promotes cell proliferation and migration by epigenetically activating NUF2 transcription and interacting with IGF2BP3. The combined elevated levels of IGF2BP3, CDKN2B-AS1, and NUF2 may serve as a prognostic indicator for shorter survival in KIRC patients, with high accuracy in discriminating high-risk from low-risk patients.

CELL DEATH & DISEASE (2021)

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Article Oncology

Nuf2 Is a Prognostic-Related Biomarker and Correlated With Immune Infiltrates in Hepatocellular Carcinoma

Xingwei Xie et al.

Summary: The study suggests that Nuf2 could serve as a potential prognostic biomarker in HCC and be associated with tumor immune cell infiltration.

FRONTIERS IN ONCOLOGY (2021)

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Article Multidisciplinary Sciences

Distinct T cell receptor repertoire diversity of clinically defined high-grade serous ovarian cancer treatment subgroups

Sanghoon Lee et al.

Summary: This study found higher TCR diversity in the R0 group and lower diversity in the NACT group among patients with high-grade serous ovarian cancer. Additionally, specific TCR beta gene enrichment and positive correlations between clonal relatedness and neoantigens, copy number variations, and mutation load were observed in the different groups.

ISCIENCE (2021)

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Article Cell Biology

Single-Cell RNA-Sequencing Portraying Functional Diversity and Clinical Implications of IFI6 in Ovarian Cancer

Hongyu Zhao et al.

Summary: In this study, prognostic subtype S1 was identified as dominant in ovarian cancer (OC) and associated with distinct survival and drug response clusters. IFI6, a vital gene in OC carcinogenesis, was found to suppress proliferation capabilities and enhance cisplatin-induced apoptosis. Functional enrichment analysis revealed a correlation between IFI6 and the NF-kappa B pathway, validating its role in OC biology. The development of a prognostic model incorporating IFI6, RiskScore, provides promising prognostic values and potential for personalized anti-cancer strategies in OC management.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Biochemistry & Molecular Biology