期刊
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
卷 15, 期 11, 页码 1864-1872出版社
IJO PRESS
DOI: 10.18240/ijo.2022.11.19
关键词
gastrointestinal microbiome; primary Sjugren's syndrome; dry eye; dysbiosis; autoimmunity; clinical therapy
资金
- Science and Technology Program for Basic Research in Shenzhen [JCYJ20200109140412476]
- Clinical Research Project of Shenzhen Second People's Hospital [20193357009]
The impact of the human gastrointestinal microbiome on human autoimmune diseases, including primary Sjogren's syndrome, has been recognized through deeper research. This review summarizes the latest knowledge about the relationship between the microbiome and pSS, providing insights into potential mechanisms and highlighting the significance for the development of new therapies targeting dry eye associated with pSS.
The recognition of the profound impact of the human gastrointestinal microbiome (GM) on human autoimmune diseases has gradually increased thanks to deeper research efforts. As a systemic autoimmune disease, primary Sjogren's syndrome (pSS) cannot be completely cured. Human studies have revealed that GM species and diversity are altered in patients with pSS compared with healthy individuals. Animal studies have provided possible mechanisms for the association between pSS and GM. The potential role of GM in pSS is exerted through several mechanisms. GM dysbiosis leads to increased intestinal permeability, which increases the risk of GM antigen exposure and activates specific autoreactive T lymphocytes via molecular mimicry. In addition, GM antigen exposure and intestinal immune tolerance loss caused by GM dysbiosis together induce chronic local gut mucosal inflammation, which deteriorates to systemic chronic non-specific inflammation with the circulation of pro-inflammatory lymphocytes and cytokines. These factors eventually activate autoreactive B lymphocytes and lead to pSS. If GM plays a key role in the pathogenesis of pSS, clarifying the underlying mechanisms will be helpful for the development of new therapies targeting GM for dry eye associated with pSS. This review summarizes the latest knowledge about the relationship between GM and pSS, with the aim of contributing to future research and to the development of new clinical applications.
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