相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。
Article
Immunology
Pieter Pannus et al.
Summary: Poor antibody responses to COVID-19 vaccination in infection-naive residents and some naive staff members of nursing homes suggest suboptimal protection, supporting the need for a third dose vaccination.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Wojciech Witkowski et al.
Summary: This study analyzed the humoral response to the BNT162b2 vaccine among nursing home residents and staff. The results showed significantly decreased serum antibody levels and neutralization titers among nursing home residents, with a high proportion of non-responders. Additionally, a significant decrease in antibody titers was observed three months post-vaccination in COVID-19-naive nursing home residents. Flow cytometry and interferon gamma secretion analyses indicated that antibody non-responders also failed to mount cellular responses. This study highlights the need for additional measures and continued monitoring in the population of frail elderly individuals.
Article
Immunology
Marina Digregorio et al.
Summary: In Belgium, vaccine hesitancy among nursing home staff may have affected vaccination rates. A study found that 29.5% of respondents hesitated before accepting vaccination, were still hesitating, or refused vaccination. The main reasons for hesitation or refusal included fear of unknown future effects, fear of side-effects, and mistrust in vaccination. Protecting the vulnerable was the main reason for hesitant participants to change their minds.
Article
Public, Environmental & Occupational Health
Heidi Janssens et al.
Summary: This study investigated the seroprevalence of SARS-CoV-2 IgG antibodies in residents and staff of 20 nursing homes in Flanders, Belgium. The results showed that nursing homes had a higher seroprevalence compared to the general population. Among the staff with antibodies, 14% reported no typical COVID-19 symptoms, while 51% of the residents with antibodies had no symptoms. The study also found a weaker association between COVID-19 symptoms and positive serology in residents compared to staff.
EPIDEMIOLOGY AND INFECTION
(2022)
Editorial Material
Immunology
David H. Canaday et al.
Summary: After receiving the BNT162b2 messenger RNA vaccine, nursing home residents had antibody neutralization titers one-quarter of healthcare workers who were naive to SARS-CoV-2.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Geriatrics & Gerontology
Sergio Salmeron Rios et al.
Summary: In a longitudinal cohort study in long-term care facilities in Albacete, Spain, 134 older adults aged >= 65 years received two doses of the BNT162b2 mRNA COVID-19 vaccine, with antibody levels measured 21.9 days after each dose. The vaccine was found to be safe and produced immunogenicity in older adults, regardless of their frailty and disability profiles. Residents with prior COVID-19 infection showed increased antibody levels post-vaccination.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Letter
Medicine, General & Internal
Timothy A. Bates et al.
Summary: This study investigates the correlation between age and neutralizing antibody levels against the SARS-CoV-2 USA-WA1/2020 strain and the P.1 variant after receiving 2 doses of the BNT162b2 vaccine.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Virology
David Triest et al.
Summary: The study assessed the performance of five SARS-CoV-2 rapid serological tests using finger prick blood, with only one (OrientGene) showing acceptable sensitivity and specificity for use in high prevalence situations in population-based seroprevalence studies.
JOURNAL OF CLINICAL VIROLOGY
(2021)
Article
Multidisciplinary Sciences
Dami A. Collier et al.
Summary: Elderly individuals, especially those above eighty, show lower immune responses and neutralization abilities against variants of concern after the first vaccine dose, but this improves after the second dose. They have higher frequencies of spike-specific memory B cells but reduced somatic hypermutation of class-switched cells. Production of interferon-gamma and interleukin-2 by SARS-CoV-2 spike-specific T cells is lower in older participants, predominantly by CD4 T cells.
Article
Immunology
Lisa Mueller et al.
Summary: The study compared antibody responses to the BNT162b2 COVID-19 vaccine in young vaccinees below 60 and elderly vaccinees over 80. The elderly group had lower antibody titers and a lower frequency of neutralizing antibodies post-vaccination, indicating a potential need for closer monitoring or different vaccination strategies for this population.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Medicine, General & Internal
Fidelia Cascini et al.
Summary: Acceptance rates of COVID-19 vaccines vary significantly between countries and time points, with Arabian countries showing higher hesitancy rates. Factors contributing to hesitancy include negative perceptions of vaccine efficacy, safety, convenience, and price. Certain socio-demographic groups identified with lower vaccine acceptance rates include women, younger participants, and individuals with lower education level, income, insurance coverage, living in rural areas, and identifying as racial/ethnic minorities.
Article
Multidisciplinary Sciences
Mark J. Mulligan et al.
Article
Medicine, General & Internal
Edward E. Walsh et al.
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Review
Immunology
Daniela Frasca et al.
CURRENT OPINION IN IMMUNOLOGY
(2014)
Article
Immunology
Tamas Fulop et al.
CLINICAL INFECTIOUS DISEASES
(2009)
Article
Immunology
I. Ridda et al.
