4.7 Review

Chemical Chaperones to Inhibit Endoplasmic Reticulum Stress: Implications in Diseases

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Toxicology

Sacubitril/valsartan reduces endoplasmic reticulum stress in a rat model of doxorubicin-induced cardiotoxicity

Byung Sik Kim et al.

Summary: Sacubitril/valsartan protects against doxorubicin-induced cardiotoxicity by reducing endoplasmic reticulum stress and apoptosis.

ARCHIVES OF TOXICOLOGY (2022)

Review Biotechnology & Applied Microbiology

Pharmacological targeting of endoplasmic reticulum stress in disease

Stefan J. Marciniak et al.

Summary: Research on drug-like molecules targeting ER stress and UPR has made progress, but limitations still exist. Understanding these limitations is crucial for the development of these molecules into therapeutic drugs.

NATURE REVIEWS DRUG DISCOVERY (2022)

Article Biochemistry & Molecular Biology

Identification of Novel Oxindole Compounds That Suppress ERStress-Induced Cell Death as Chemical Chaperones

Yuto Hasegawa et al.

Summary: This paper identifies several novel oxindole compounds that can prevent ER stress- and oxidative stress-induced cell death and suppress protein aggregate accumulation. These compounds also prevent glutamate-induced oxytosis and erastin-induced ferroptosis. The results suggest that these compounds may be useful therapeutics against protein-misfolding diseases and valuable research tools for studying the molecular mechanisms of ER and oxidative stress.

ACS CHEMICAL NEUROSCIENCE (2022)

Article Biochemistry & Molecular Biology

Discovery and structural optimization of 9-O-phenylsulfonyl-berberines as new lipid-lowering agents

Yuan Kong et al.

Summary: In this study, a series of berberine analogs were synthesized and evaluated for their lipid-lowering activities. Compound 1m was found to exhibit potent cholesterol inhibitory activity and had significant effects on LDLC and HDLC levels. The results suggest that 1m has the potential to be a new lipid-lowering agent.

BIOORGANIC CHEMISTRY (2022)

Article Chemistry, Medicinal

trans, trans-2-C-Aryl-3,4-dihydroxypyrrolidines as potent and selective ?-glucosidase inhibitors: Pharmacological chaperones for Gaucher disease

Jun-Zhe Wang et al.

Summary: Enantiomeric series of C-4 hydroxymethyl depleted DAB and LAB derivatives were synthesized and evaluated as potent and selective GCase inhibitors. The study provides a strategy for the development of drugs for the treatment of acid beta-glucosidase related diseases.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)

Review Biochemistry & Molecular Biology

Endoplasmic Reticulum (ER) Stress and Its Role in Pancreatic β-Cell Dysfunction and Senescence in Type 2 Diabetes

Ji-Hye Lee et al.

Summary: Increased life span and nutritional affluency have resulted in a rise in age-related diseases, such as obesity and type 2 diabetes, which impose significant burdens on society. Dysfunction of pancreatic beta-cells, responsible for glucose control, plays a crucial role in both type 1 and type 2 diabetes. Recent studies have linked cellular senescence to cellular stresses, including ER stress, and have shown that beta-cell senescence contributes to dysfunction and impaired glucose homeostasis. This review discusses the current understanding of cellular senescence, beta-cell function, ER stress, and its impact on beta-cell senescence and dysfunction.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Biochemistry & Molecular Biology

sp2-Iminosugars targeting human lysosomal β-hexosaminidase as pharmacological chaperone candidates for late-onset Tay-Sachs disease

Manuel Gonzalez-Cuesta et al.

Summary: Late-onset Tay-Sachs disease is caused by decreased enzyme activity, and competitive inhibitors can serve as pharmacological chaperones to rescue the disease. However, they also inhibit another enzyme at the same time.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2022)

Article Cell Biology

A non-canonical cGAS-STING-PERK pathway facilitates the translational program critical for senescence and organ fibrosis

Dan Zhang et al.

Summary: The non-canonical cGAS-STING pathway, involving the activation of PERK-eIF2 alpha, contributes to mRNA translation and plays a role in cellular senescence and fibrosis. This finding sheds light on the connection between DNA sensing and cellular physiology, and suggests the therapeutic potential of targeting the STING-PERK pathway in fibrotic diseases.

NATURE CELL BIOLOGY (2022)

Article Immunology

PERK is a critical metabolic hub for immunosuppressive function in macrophages

Lydia N. Raines et al.

Summary: This study reveals the importance of PERK signaling and PSAT1-mediated serine metabolism in promoting the immunosuppressive function of M2 macrophages, providing new insights into the molecular mechanisms of immune cell suppressive phenotype.

NATURE IMMUNOLOGY (2022)

Article Pharmacology & Pharmacy

Endoplasmic reticulum stress: A common pharmacologic target of cardioprotective drugs

Arshag D. Mooradian et al.

Summary: Despite advances in cardiovascular disease prevention, there is still a significant risk of adverse cardiovascular events. Reducing cellular stresses, particularly inflammatory stress and endoplasmic reticulum stress, may further reduce cardiovascular disease risk.

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

Article Biochemistry & Molecular Biology

Identification of an endoplasmic reticulum proteostasis modulator that enhances insulin production in pancreatic ? cells

Masato Miyake et al.

Summary: A small molecule called KM04794 has been identified to alleviate protein aggregation and cell death caused by ER stress, and enhance insulin levels, thereby improving the function of pancreatic insulin-secreting cells.

CELL CHEMICAL BIOLOGY (2022)

Article Chemistry, Medicinal

Ligand-based rational design, synthesis and evaluation of novel potential chemical chaperones for opsin

Gaia Pasqualetto et al.

Summary: This study investigated the use of opsin-binding compounds as chemical chaperones to prevent the loss of photoreceptors in inherited blinding diseases. By conducting molecular docking studies on the main chromophore binding site of rhodopsin, 49 novel compounds were synthesized, with some showing potential as chemical chaperones or stabilizers.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Review Endocrinology & Metabolism

A guide to understanding endoplasmic reticulum stress in metabolic disorders

Imke L. Lemmer et al.

Summary: This review provides a general guide to understanding the nature, etiology, and consequences of ER stress in metabolic disorders, emphasizing key mechanisms such as protein quality control, lipid and carbohydrate metabolism, and inflammation.

MOLECULAR METABOLISM (2021)

Review Pharmacology & Pharmacy

Pharmacological Targeting of Endoplasmic Reticulum Stress in Pancreatic Beta Cells

Sara Bilekova et al.

Summary: Diabetes is a global pandemic disease with no pharmacological treatment to prevent its progression. Restoring beta-cell function may be a potential therapeutic approach to improve diabetes.

TRENDS IN PHARMACOLOGICAL SCIENCES (2021)

Article Chemistry, Medicinal

From the Design to the In Vivo Evaluation of Benzohomoadamantane-Derived Soluble Epoxide Hydrolase Inhibitors for the Treatment of Acute Pancreatitis

Sandra Codony et al.

Summary: Inhibition of soluble epoxide hydrolase (sEH) has shown efficacy in treating inflammatory and pain-related diseases. New sEH inhibitors with benzohomoadamantane scaffold demonstrated excellent inhibitory activities, showing potential for the design of novel sEHIs. Molecular dynamics simulations and in vivo studies in a murine model of acute pancreatitis supported the promising efficacy of these compounds in improving health status and reducing pancreatic damage.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

Review Biochemistry & Molecular Biology

How do Chaperones Bind (Partly) Unfolded Client Proteins?

Iva Sucec et al.

Summary: Molecular chaperones play a crucial role in maintaining cellular protein homeostasis, with dynamic disorder facilitating the release or handover of client proteins. Recent studies emphasize the importance of dynamics in chaperone-client interactions, with various interaction types contributing to complex formation.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

Article Pharmacology & Pharmacy

Effect of anti-hyperglycemic drugs on endoplasmic reticulum (ER) stress in human coronary artery endothelial cells

Poonam Kapadia et al.

Summary: Research has shown that metformin, some GLP-1 receptor agonists, and SGLT-2 inhibitors can reduce endoplasmic reticulum (ER) stress caused by pharmacological or hyperglycemic conditions, potentially contributing to their cardioprotective effects.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

Review Endocrinology & Metabolism

Therapeutic opportunities for pancreatic β-cell ER stress in diabetes mellitus

Jing Yong et al.

Summary: Diabetes mellitus can result from autoimmunity or insulin resistance leading to beta-cell failure, with critical gene mutations causing monogenic diabetes. The endoplasmic reticulum plays a crucial role in insulin secretion and storage, and ER stress is associated with the pathogenesis of diabetes.

NATURE REVIEWS ENDOCRINOLOGY (2021)

Article Chemistry, Medicinal

Bi-aryl Analogues of Salicylic Acids: Design, Synthesis and SAR Study to Ameliorate Endoplasmic Reticulum Stress

Ye Eun Kim et al.

Summary: By synthesizing bi-aryl analogues of salicylic acid, this study found that many analogues reduced ER stress, with the best compound showing up to almost 6-fold better activity than positive controls. The flat conformation of the aromatic region played a crucial role in the activity of these analogues.

DRUG DESIGN DEVELOPMENT AND THERAPY (2021)

Article Immunology

Suppression of Endoplasmic Reticulum Stress by 4-PBA Protects Against Hyperoxia-Induced Acute Lung Injury via Up-Regulating Claudin-4 Expression

Hsin-Ping Pao et al.

Summary: The study revealed that the ER stress inhibitor 4-PBA can protect against hyperoxia-induced acute lung injury by enhancing claudin-4 expression, leading to prolongation of survival in mice, reduction in inflammatory mediators, and protein levels in bronchoalveolar lavage fluid.

FRONTIERS IN IMMUNOLOGY (2021)

Review Cell Biology

Therapeutic Effects of Natural Compounds and Small Molecule Inhibitors Targeting Endoplasmic Reticulum Stress in Alzheimer's Disease

Xun Gao et al.

Summary: Alzheimer's disease is the most common neurodegenerative disease characterized by progressive cognitive impairment and memory loss. Research indicates that endoplasmic reticulum stress and unfolded protein response play a role in the pathogenesis of AD. Targeting ER stress and ER stress-mediated apoptosis may be effective in treating AD.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Review Biochemistry & Molecular Biology

Regulation of matrix metalloproteinases 2 and 9 in corneal neovascularization

Jiahao Zhang et al.

CHEMICAL BIOLOGY & DRUG DESIGN (2020)

Article Chemistry, Medicinal

Design and Synthesis of Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors

David S. Huang et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

Review Pharmacology & Pharmacy

Acute lung injury: The therapeutic role of Rho kinase inhibitors

Farshad Abedi et al.

PHARMACOLOGICAL RESEARCH (2020)

Article Pharmacology & Pharmacy

Should we keep rocking? Portraits from targeting Rho kinases in cancer

Graziella Ribeiro de Sousa et al.

PHARMACOLOGICAL RESEARCH (2020)

Review Pharmacology & Pharmacy

Role of Soluble Epoxide Hydrolase in Metabolism of PUFAs in Psychiatric and Neurological Disorders

Kenji Hashimoto

FRONTIERS IN PHARMACOLOGY (2019)

Article Biochemistry & Molecular Biology

Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding

Annette N. Chiang et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2019)

Article Medicine, Research & Experimental

Inhibition of CACNA1H attenuates doxorubicin-induced acute cardiotoxicity by affecting endoplasmic reticulum stress

Junxia Hu et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Article Chemistry, Multidisciplinary

Gluco-1H-imidazole: A New Class of Azole-Type β-Glucosidase Inhibitor

Sybrin P. Schroder et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

Review Pharmacology & Pharmacy

Natural products targeting ER stress pathway for the treatment of cardiovascular diseases

Ker Woon Choy et al.

PHARMACOLOGICAL RESEARCH (2018)

Article Biotechnology & Applied Microbiology

Vildagliptin Can Alleviate Endoplasmic Reticulum Stress in the Liver Induced by a High Fat Diet

Xiaoqing Ma et al.

BIOMED RESEARCH INTERNATIONAL (2018)

Review Chemistry, Medicinal

Berberine Derivatives with Different Pharmacological Activities via Structural Modifications

Daipeng Xiao et al.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2018)

Article Chemistry, Medicinal

Discovery of a Benzamide Derivative That Protects Pancreatic β-Cells against Endoplasmic Reticulum Stress

Hongliang Duan et al.

JOURNAL OF MEDICINAL CHEMISTRY (2017)

Review Pharmacology & Pharmacy

Unraveling the role of ER stress inhibitors in the context of metabolic diseases

Chodisetty Sarvani et al.

PHARMACOLOGICAL RESEARCH (2017)

Article Multidisciplinary Sciences

Rtn1a-Mediated Endoplasmic Reticulum Stress in Podocyte Injury and Diabetic Nephropathy

Ying Fan et al.

SCIENTIFIC REPORTS (2017)

Review Endocrinology & Metabolism

Oxidative and endoplasmic reticulum stress in β-cell dysfunction in diabetes

Sumaira Z. Hasnain et al.

JOURNAL OF MOLECULAR ENDOCRINOLOGY (2016)

Article Chemistry, Medicinal

Synthesis and hypoglycemic activity of 9-O-(lipophilic group substituted) berberine derivatives

Shanshan Zhang et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)

Article Pharmacology & Pharmacy

Anti-diabetic effect of 3-hydroxy-2-naphthoic acid, an endoplasmic reticulum stress-reducing chemical chaperone

Sun-mi Park et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2016)

Article Chemistry, Medicinal

Novel Tetrahydropyrido[4,3-d]pyrimidines as Potent Inhibitors of Chaperone Heat Shock Protein 90

Fen Jiang et al.

JOURNAL OF MEDICINAL CHEMISTRY (2016)

Review Endocrinology & Metabolism

Endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation

Kira Meyerovich et al.

JOURNAL OF MOLECULAR ENDOCRINOLOGY (2016)

Review Multidisciplinary Sciences

Protein misfolding in the endoplasmic reticulum as a conduit to human disease

Miao Wang et al.

NATURE (2016)

Article Multidisciplinary Sciences

Tauroursodeoxycholic acid reduces ER stress by regulating of Akt-dependent cellular prion protein

Yeo Min Yoon et al.

SCIENTIFIC REPORTS (2016)

Review Biochemistry & Molecular Biology

The therapeutic effects of 4-phenylbutyric acid in maintaining proteostasis

P. S. Kolb et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2015)

Article Chemistry, Medicinal

Synthesis and in vitro evaluation of 12-(substituted aminomethyl) berberrubine derivatives as anti-diabetics

Renjun Li et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)

Article Multidisciplinary Sciences

Guanabenz Interferes with ER Stress and Exerts Protective Effects in Cardiac Myocytes

Christiane Neuber et al.

PLOS ONE (2014)

Article Biochemistry & Molecular Biology

Chemical Induction of Hsp70 Reduces α-Synuclein Aggregation in Neuroglioma Cells

Kiri Kilpatrick et al.

ACS CHEMICAL BIOLOGY (2013)

Article Biochemistry & Molecular Biology

Fasudil inhibits ER stress-induced VCAM-1 expression by modulating unfolded protein response in endothelial cells

Daiji Kawanami et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)

Review Biotechnology & Applied Microbiology

Targeting the unfolded protein response in disease

Claudio Hetz et al.

NATURE REVIEWS DRUG DISCOVERY (2013)

Article Biochemistry & Molecular Biology

A novel fully human antitumor ImmunoRNase resistant to the RNase inhibitor

Gennaro Riccio et al.

PROTEIN ENGINEERING DESIGN & SELECTION (2013)

Article Multidisciplinary Sciences

Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress

Sudarshana Purkayastha et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Biochemistry & Molecular Biology

Binding of a Small Molecule at a Protein-Protein Interface Regulates the Chaperone Activity of Hsp70-Hsp40

Susanne Wisen et al.

ACS CHEMICAL BIOLOGY (2010)

Article Medicine, Research & Experimental

The Rho kinase inhibitor fasudil inhibits the migratory behaviour of 95-D lung carcinoma cells

Xueying Yang et al.

BIOMEDICINE & PHARMACOTHERAPY (2010)

Article Biochemistry & Molecular Biology

Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors

Ling Huang et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2010)

Editorial Material Biochemistry & Molecular Biology

How IRe1 reacts to ER stress

David Ron et al.

Review Endocrinology & Metabolism

The role for endoplasmic reticulum stress in diabetes mellitus

Decio L. Eizirik et al.

ENDOCRINE REVIEWS (2008)

Article Biochemistry & Molecular Biology

Simple inhibitors of histone deacetylase activity that combine features of short-chain fatty acid and hydroxamic acid inhibitors

Jessica L. Tischler et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2008)

Review Multidisciplinary Sciences

From endoplasmic-reticulum stress to the inflammatory response

Kezhong Zhang et al.

NATURE (2008)

Review Biotechnology & Applied Microbiology

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

Inki Kim et al.

NATURE REVIEWS DRUG DISCOVERY (2008)

Article Multidisciplinary Sciences

Antihypertensive Drug Guanabenz Is Active In Vivo against both Yeast and Mammalian Prions

Deborah Tribouillard-Tanvier et al.

PLOS ONE (2008)

Article Multidisciplinary Sciences

A selective inhibitor-of eIF2α dephosphorylation protects cells from ER stress

M Boyce et al.

SCIENCE (2005)

Article Clinical Neurology

Treatment of cerebral vasospasm with intra-arterial fasudil hydrochloride

K Tanaka et al.

NEUROSURGERY (2005)