相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Sacubitril/valsartan reduces endoplasmic reticulum stress in a rat model of doxorubicin-induced cardiotoxicity
Byung Sik Kim et al.
ARCHIVES OF TOXICOLOGY (2022)
Pharmacological targeting of endoplasmic reticulum stress in disease
Stefan J. Marciniak et al.
NATURE REVIEWS DRUG DISCOVERY (2022)
Identification of Novel Oxindole Compounds That Suppress ERStress-Induced Cell Death as Chemical Chaperones
Yuto Hasegawa et al.
ACS CHEMICAL NEUROSCIENCE (2022)
Discovery and structural optimization of 9-O-phenylsulfonyl-berberines as new lipid-lowering agents
Yuan Kong et al.
BIOORGANIC CHEMISTRY (2022)
trans, trans-2-C-Aryl-3,4-dihydroxypyrrolidines as potent and selective ?-glucosidase inhibitors: Pharmacological chaperones for Gaucher disease
Jun-Zhe Wang et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)
Endoplasmic Reticulum (ER) Stress and Its Role in Pancreatic β-Cell Dysfunction and Senescence in Type 2 Diabetes
Ji-Hye Lee et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
sp2-Iminosugars targeting human lysosomal β-hexosaminidase as pharmacological chaperone candidates for late-onset Tay-Sachs disease
Manuel Gonzalez-Cuesta et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2022)
A non-canonical cGAS-STING-PERK pathway facilitates the translational program critical for senescence and organ fibrosis
Dan Zhang et al.
NATURE CELL BIOLOGY (2022)
PERK is a critical metabolic hub for immunosuppressive function in macrophages
Lydia N. Raines et al.
NATURE IMMUNOLOGY (2022)
Endoplasmic reticulum stress: A common pharmacologic target of cardioprotective drugs
Arshag D. Mooradian et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2022)
Identification of an endoplasmic reticulum proteostasis modulator that enhances insulin production in pancreatic ? cells
Masato Miyake et al.
CELL CHEMICAL BIOLOGY (2022)
Ligand-based rational design, synthesis and evaluation of novel potential chemical chaperones for opsin
Gaia Pasqualetto et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)
A guide to understanding endoplasmic reticulum stress in metabolic disorders
Imke L. Lemmer et al.
MOLECULAR METABOLISM (2021)
Pharmacological Targeting of Endoplasmic Reticulum Stress in Pancreatic Beta Cells
Sara Bilekova et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2021)
From the Design to the In Vivo Evaluation of Benzohomoadamantane-Derived Soluble Epoxide Hydrolase Inhibitors for the Treatment of Acute Pancreatitis
Sandra Codony et al.
JOURNAL OF MEDICINAL CHEMISTRY (2021)
How do Chaperones Bind (Partly) Unfolded Client Proteins?
Iva Sucec et al.
FRONTIERS IN MOLECULAR BIOSCIENCES (2021)
Effect of anti-hyperglycemic drugs on endoplasmic reticulum (ER) stress in human coronary artery endothelial cells
Poonam Kapadia et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2021)
Therapeutic opportunities for pancreatic β-cell ER stress in diabetes mellitus
Jing Yong et al.
NATURE REVIEWS ENDOCRINOLOGY (2021)
Bi-aryl Analogues of Salicylic Acids: Design, Synthesis and SAR Study to Ameliorate Endoplasmic Reticulum Stress
Ye Eun Kim et al.
DRUG DESIGN DEVELOPMENT AND THERAPY (2021)
Suppression of Endoplasmic Reticulum Stress by 4-PBA Protects Against Hyperoxia-Induced Acute Lung Injury via Up-Regulating Claudin-4 Expression
Hsin-Ping Pao et al.
FRONTIERS IN IMMUNOLOGY (2021)
Therapeutic Effects of Natural Compounds and Small Molecule Inhibitors Targeting Endoplasmic Reticulum Stress in Alzheimer's Disease
Xun Gao et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)
Regulation of matrix metalloproteinases 2 and 9 in corneal neovascularization
Jiahao Zhang et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2020)
Design and Synthesis of Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors
David S. Huang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Berberine inhibits free fatty acid and LPS-induced inflammation via modulating ER stress response in macrophages and hepatocytes
Yanyan Wang et al.
PLOS ONE (2020)
Acute lung injury: The therapeutic role of Rho kinase inhibitors
Farshad Abedi et al.
PHARMACOLOGICAL RESEARCH (2020)
2-Oxaadamant-1-yl Ureas as Soluble Epoxide Hydrolase Inhibitors: In Vivo Evaluation in a Murine Model of Acute Pancreatitis
Sandra Codony et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Should we keep rocking? Portraits from targeting Rho kinases in cancer
Graziella Ribeiro de Sousa et al.
PHARMACOLOGICAL RESEARCH (2020)
Binding to an Unusual Inactive Kinase Conformation by Highly Selective Inhibitors of Inositol-Requiring Enzyme 1α Kinase-Endoribonuclease
Giampiero Colombano et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Role of Soluble Epoxide Hydrolase in Metabolism of PUFAs in Psychiatric and Neurological Disorders
Kenji Hashimoto
FRONTIERS IN PHARMACOLOGY (2019)
13-Ethylberberine Induces Apoptosis through the Mitochondria-Related Apoptotic Pathway in Radiotherapy-Resistant Breast Cancer Cells
Hana Jin et al.
MOLECULES (2019)
Synthesis and anti-endoplasmic reticulum stress activity of N-substituted-2-arylcarbonylhydrazinecarbothioamides
Hoon Choi et al.
MEDICINAL CHEMISTRY RESEARCH (2019)
Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding
Annette N. Chiang et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2019)
Inhibition of CACNA1H attenuates doxorubicin-induced acute cardiotoxicity by affecting endoplasmic reticulum stress
Junxia Hu et al.
BIOMEDICINE & PHARMACOTHERAPY (2019)
Discovery of 3-Ethyl-4-(3-isopropyl-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl)benzannide (TAS-116) as a Potent, Selective, and Orally Available HSP90 Inhibitor
Takao Uno et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Cell-based HTS identifies a chemical chaperone for preventing ER protein aggregation and proteotoxicity
Keisuke Kitakaze et al.
ELIFE (2019)
Fasudil inhibits neutrophil-endothelial cell interactions by regulating the expressions of GRP78 and BMPR2
Jingjing Wang et al.
EXPERIMENTAL CELL RESEARCH (2018)
Gluco-1H-imidazole: A New Class of Azole-Type β-Glucosidase Inhibitor
Sybrin P. Schroder et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)
Natural products targeting ER stress pathway for the treatment of cardiovascular diseases
Ker Woon Choy et al.
PHARMACOLOGICAL RESEARCH (2018)
Vildagliptin Can Alleviate Endoplasmic Reticulum Stress in the Liver Induced by a High Fat Diet
Xiaoqing Ma et al.
BIOMED RESEARCH INTERNATIONAL (2018)
Berberine Derivatives with Different Pharmacological Activities via Structural Modifications
Daipeng Xiao et al.
MINI-REVIEWS IN MEDICINAL CHEMISTRY (2018)
Rapid preparation of (3R,4S,5R) polyhydroxylated pyrrolidine-based libraries to discover a pharmacological chaperone for treatment of Fabry disease
Wei-Chieh Cheng et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
Discovery of a Benzamide Derivative That Protects Pancreatic β-Cells against Endoplasmic Reticulum Stress
Hongliang Duan et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
Unraveling the role of ER stress inhibitors in the context of metabolic diseases
Chodisetty Sarvani et al.
PHARMACOLOGICAL RESEARCH (2017)
PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz
Ana Crespillo-Casado et al.
ELIFE (2017)
Rtn1a-Mediated Endoplasmic Reticulum Stress in Podocyte Injury and Diabetic Nephropathy
Ying Fan et al.
SCIENTIFIC REPORTS (2017)
Phenanthridin-6-one derivatives as the first class of non-steroidal pharmacological chaperones for Niemann-Pick disease type C1 protein
Hiromitsu Fukuda et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)
Oxidative and endoplasmic reticulum stress in β-cell dysfunction in diabetes
Sumaira Z. Hasnain et al.
JOURNAL OF MOLECULAR ENDOCRINOLOGY (2016)
Identification of 1,2,3-triazole derivatives that protect pancreatic β cells against endoplasmic reticulum stress-mediated dysfunction and death through the inhibition of C/EBP-homologous protein expression
Hongliang Duan et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2016)
Synthesis and hypoglycemic activity of 9-O-(lipophilic group substituted) berberine derivatives
Shanshan Zhang et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)
Anti-diabetic effect of 3-hydroxy-2-naphthoic acid, an endoplasmic reticulum stress-reducing chemical chaperone
Sun-mi Park et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2016)
Novel Tetrahydropyrido[4,3-d]pyrimidines as Potent Inhibitors of Chaperone Heat Shock Protein 90
Fen Jiang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Discovery, Synthesis, and Evaluation of 2,4-Diaminoquinazolines as a Novel Class of Pancreatic β-Cell-Protective Agents against Endoplasmic Reticulum (ER) Stress
Hongliang Duan et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation
Kira Meyerovich et al.
JOURNAL OF MOLECULAR ENDOCRINOLOGY (2016)
Protein misfolding in the endoplasmic reticulum as a conduit to human disease
Miao Wang et al.
NATURE (2016)
Tauroursodeoxycholic acid reduces ER stress by regulating of Akt-dependent cellular prion protein
Yeo Min Yoon et al.
SCIENTIFIC REPORTS (2016)
Valsartan protects HK-2 cells from contrast media-induced apoptosis by inhibiting endoplasmic reticulum stress
Ping-an Peng et al.
CELL BIOLOGY INTERNATIONAL (2015)
The therapeutic effects of 4-phenylbutyric acid in maintaining proteostasis
P. S. Kolb et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2015)
Discovery of 1H-Pyrazol-3(2H)-ones as Potent and Selective Inhibitors of Protein Kinase R-like Endoplasmic Reticulum Kinase (PERK)
Adrian L. Smith et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit
Indrajit Das et al.
SCIENCE (2015)
Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity
Suneng Fu et al.
SCIENCE TRANSLATIONAL MEDICINE (2015)
Endoplasmic Reticulum Stress-Activated Cell Reprogramming in Oncogenesis
Eric Chevet et al.
CANCER DISCOVERY (2015)
Identification of Small Molecules That Protect Pancreatic β Cells against Endoplasmic Reticulum Stress-Induced Cell Death
Kim Tran et al.
ACS CHEMICAL BIOLOGY (2014)
Synthesis and in vitro evaluation of 12-(substituted aminomethyl) berberrubine derivatives as anti-diabetics
Renjun Li et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)
Heat Shock Protein 70 Inhibitors. 2. 2,5′-Thiodipyrimidines, 5-(Phenylthio)pyrimidines, 2-(Pyridin-3-ylthio)pyrimidines, and 3-(Phenylthio)pyridines as Reversible Binders to an Allosteric Site on Heat Shock Protein 70
Tony Taldone et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Design of Potent and Selective Inhibitors to Overcome Clinical Anaplastic Lymphoma Kinase Mutations Resistant to Crizotinib
Qinhua Huang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Guanabenz Interferes with ER Stress and Exerts Protective Effects in Cardiac Myocytes
Christiane Neuber et al.
PLOS ONE (2014)
Chaperones Ameliorate Beta Cell Dysfunction Associated with Human Islet Amyloid Polypeptide Overexpression
Lisa Cadavez et al.
PLOS ONE (2014)
Chemical Induction of Hsp70 Reduces α-Synuclein Aggregation in Neuroglioma Cells
Kiri Kilpatrick et al.
ACS CHEMICAL BIOLOGY (2013)
Fasudil inhibits ER stress-induced VCAM-1 expression by modulating unfolded protein response in endothelial cells
Daiji Kawanami et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)
Hydroxynaphthoic Acids Identified in a High Throughput Screening Potently Ameliorate Endoplasmic Reticulum Stress as Novel Chemical Chaperones
Kwi-wan Jeong et al.
CHEMICAL & PHARMACEUTICAL BULLETIN (2013)
Targeting the unfolded protein response in disease
Claudio Hetz et al.
NATURE REVIEWS DRUG DISCOVERY (2013)
A novel fully human antitumor ImmunoRNase resistant to the RNase inhibitor
Gennaro Riccio et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2013)
Restoration of the Unfolded Protein Response in Pancreatic β Cells Protects Mice Against Type 1 Diabetes
Feyza Engin et al.
SCIENCE TRANSLATIONAL MEDICINE (2013)
Islet β-Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model
Sarah A. Tersey et al.
DIABETES (2012)
Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)
Jeffrey M. Axten et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Fasudil Protects the Heart against Ischemia-Reperfusion Injury by Attenuating Endoplasmic Reticulum Stress and Modulating SERCA Activity: The Differential Role for PI3K/Akt and JAK2/STAT3 Signaling Pathways
Yapeng Li et al.
PLOS ONE (2012)
1-(1-Acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia
Sampath-Kumar Anandan et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)
Sodium Phenylbutyrate, a Drug With Known Capacity to Reduce Endoplasmic Reticulum Stress, Partially Alleviates Lipid-Induced Insulin Resistance and β-Cell Dysfunction in Humans
Changting Xiao et al.
DIABETES (2011)
Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress
Sudarshana Purkayastha et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Binding of a Small Molecule at a Protein-Protein Interface Regulates the Chaperone Activity of Hsp70-Hsp40
Susanne Wisen et al.
ACS CHEMICAL BIOLOGY (2010)
Berberine-Induced Apoptosis in Human Glioblastoma T98G Cells Is Mediated by Endoplasmic Reticulum Stress Accompanying Reactive Oxygen Species and Mitochondrial Dysfunction
Ki Seong Eom et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2010)
The Rho kinase inhibitor fasudil inhibits the migratory behaviour of 95-D lung carcinoma cells
Xueying Yang et al.
BIOMEDICINE & PHARMACOTHERAPY (2010)
Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors
Ling Huang et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2010)
Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase
Ling Huang et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2010)
Effects of fasudil on early atherosclerotic plaque formation and established lesion progression in apolipoprotein E-knockout mice
Duo-Jiao Wu et al.
ATHEROSCLEROSIS (2009)
How IRe1 reacts to ER stress
David Ron et al.
CELL (2008)
The role for endoplasmic reticulum stress in diabetes mellitus
Decio L. Eizirik et al.
ENDOCRINE REVIEWS (2008)
Simple inhibitors of histone deacetylase activity that combine features of short-chain fatty acid and hydroxamic acid inhibitors
Jessica L. Tischler et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2008)
From endoplasmic-reticulum stress to the inflammatory response
Kezhong Zhang et al.
NATURE (2008)
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities
Inki Kim et al.
NATURE REVIEWS DRUG DISCOVERY (2008)
Antihypertensive Drug Guanabenz Is Active In Vivo against both Yeast and Mammalian Prions
Deborah Tribouillard-Tanvier et al.
PLOS ONE (2008)
Selective inhibition of eukaryotic translation initiation factor 2α dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic β-cell dysfunction and apoptosis
Miriam Cnop et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Design and synthesis of highly potent and selective pharmacological chaperones for the treatment of Gaucher's disease
Philippe Compain et al.
CHEMBIOCHEM (2006)
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
Umut Oezcan et al.
SCIENCE (2006)
A selective inhibitor-of eIF2α dephosphorylation protects cells from ER stress
M Boyce et al.
SCIENCE (2005)
Treatment of cerebral vasospasm with intra-arterial fasudil hydrochloride
K Tanaka et al.
NEUROSURGERY (2005)
The role of the unfolded protein response in tumour development: Friend or foe?
YJ Ma et al.
NATURE REVIEWS CANCER (2004)