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Review
Medicine, Research & Experimental
Zhe Wen Zhou et al.
Summary: Exosomes, as a crucial intercellular communication method, participate in the development of liver diseases by carrying nucleic acids, proteins, and other substances. Exosome-derived ncRNAs have significant potential and clinical implications in the diagnosis and treatment of liver diseases.
LABORATORY INVESTIGATION
(2022)
Article
Pathology
Lanlan Wan et al.
Summary: The study revealed that lncRNA SNHG16 is upregulated in LSCC and contributes to its development by regulating the miR-140-5p/NFAT5/Wnt/beta-catenin pathway axis, potentially providing a novel strategy for LSCC treatment.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Medicine, Research & Experimental
Manuela Cabiati et al.
Summary: This study analyzed the transcriptional profile of miRNAs and lncRNAs in EVs derived from HepG2 and WRL68 cell lines, revealing lower expression of miR-181a, miR-205, and miR-1323 in HepG2 EVs compared to WRL68, as well as significant correlations between multiple miRNAs and lncRNAs. These findings suggest potential new diagnostic and prognostic biomarkers for HCC.
CLINICAL AND EXPERIMENTAL MEDICINE
(2022)
Review
Medicine, Research & Experimental
Kangkang Yang et al.
Summary: Exosome-derived noncoding RNAs play an important role in tumor angiogenesis. This review outlines the characteristics of exosomes, noncoding RNAs, and tumor angiogenesis, and analyzes the mechanism of how exosome-derived noncoding RNAs impact tumor angiogenesis. The review emphasizes the regulatory role of exosome-derived noncoding RNAs in angiogenesis in different types of cancer and highlights their potential as biomarkers for cancer diagnosis and therapeutic targets.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Cell Biology
Denghui Wei et al.
Summary: RAB31 plays a dual role in exosome biogenesis by driving ILVs formation and suppressing the fusion of MVEs with lysosomes, providing a better understanding of the exosome biogenesis process.
Article
Cell Biology
Ying Xu et al.
Summary: This study revealed the role of Telocytes (TCs) in promoting tumor metastasis in hepatocellular carcinoma (HCC) and demonstrated their potential as novel prognostic markers for HCC. TCs were found to promote HCC cell metastasis through MMP9 expression in vitro and in vivo, indicating their involvement in tumorigenic, invasive, and migratory processes in HCC. Additionally, the study showed that Platelet-derived growth factor-alpha (PDGF-alpha) and miR-942-3p play key roles in regulating MMP9 expression in TCs.
CELL DEATH DISCOVERY
(2021)
Review
Cell Biology
Mary Catherine Bridges et al.
Summary: This review summarizes the current knowledge of subcellular localization of long noncoding RNAs (lncRNAs), factors controlling their localization, emerging themes, and discusses the implications of lncRNA localization on their function and cellular behavior, as well as opportunities for future research.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Cell Biology
Xi-wu Zhang et al.
Summary: In this study, ZFPM2-AS1 was identified as a novel HCC-related lncRNA, showing distinct upregulation in HCC tissues induced by STAT1. Its overexpression led to changes in cell proliferation, metastasis, and apoptosis. ZFPM2-AS1 also modulated the effects of miR-653 on HCC cell proliferation and metastasis by regulating the target gene GOLM1. This interaction mechanism may provide insights for developing prognostic biomarkers and therapeutic targets for HCC.
CELL DEATH & DISEASE
(2021)
Review
Pharmacology & Pharmacy
Jinyi Liu et al.
Summary: Exosomes are cell-derived nanovesicles that play essential roles in intercellular communication, cancer progression, and drug delivery. They have potential applications in cancer diagnosis, treatment, and research.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Oncology
Hyuna Sung et al.
Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.
CA-A CANCER JOURNAL FOR CLINICIANS
(2021)
Article
Oncology
Eunice Eugenia Robless et al.
Summary: Extracellular vesicles, particularly exosomes, are key players in intercellular communication, with a specific focus on their role in pancreatic cancer. Long non-coding RNAs (lncRNAs) within these vesicles are of increasing interest as potential biomarkers and therapeutic targets for pancreatic cancer, yet their precise functions within cancer exosomes remain unclear.
Article
Biology
Min Shi et al.
Summary: The study revealed that SNHG16 promotes proliferation and migration of AML cells by suppressing CELF2 protein, impacting the PTEN/PI3K/AKT pathway.
JOURNAL OF BIOSCIENCES
(2021)
Article
Multidisciplinary Sciences
Soha A. Soliman
Summary: This study investigated the role of Telocytes (TCs) in angiogenesis during embryonic development of quail, confirming their importance through morphology, immunohistochemistry, and electron microscopy methods. TCs play a crucial role in angiogenesis through paracrine signaling.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Xiao Xiao et al.
Summary: This study identified the expression and function of lncRNA SNHG16 in osteosarcoma, showing that it acts as an oncogene by regulating miR-1285-3p, potentially serving as a novel target for osteosarcoma therapy.
Review
Cell Biology
Sonam Gurung et al.
Summary: Exosomes have vast potential in clinical applications, and understanding their biology is crucial. The processes of exosome biogenesis, transport, and uptake involve numerous influencing factors.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Lucio Diaz-Flores et al.
Summary: The study supports the hypothesis that resident CD34+ stromal cells/telocytes are an important source of cancer-associated fibroblasts in invasive lobular carcinomas. Further research is needed to explore this in other types of tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Biochemistry & Molecular Biology
Sanda Maria Cretoiu
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Yi Yi et al.
Summary: Breast cancer is the most common malignancy among women worldwide, and exosomal non-coding RNAs play significant regulatory roles in breast cancer cells, affecting angiogenesis, immunoregulation, proliferation, and migration.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Jingjing Yao et al.
Summary: This study found that high expression of CASC9 in HCC is closely related to poor prognosis, tumor characteristics, and negative correlation with miR-424-5p. Down-regulation of CASC9 can reduce proliferation and invasion of HCC cells and increase apoptosis. In addition, inhibition of miR-424-5p can enhance proliferation and invasion of HCC cells while decreasing apoptosis.
ANNALS OF HEPATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shuangda Li et al.
Summary: The study revealed that SNHG16, through exosomes, enhances the proliferative, migratory, and angiogenic effects of HCC cells on endothelial cells, further activating the PI3K/Akt/mTOR pathway to promote tumor growth. Exosomal SNHG16 may serve as a therapeutic target for anti-angiogenesis in HCC progression.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Editorial Material
Biochemical Research Methods
David W. Greening et al.
Article
Oncology
Angelica Ortiz
Summary: Aggressive cancer cells release extracellular vesicles with higher protein content, which downregulate type I interferon receptor subunit 1 and impact the expression of interferon stimulated genes. Inhibiting the uptake of extracellular vesicles and developing strategies to suppress disease progression are crucial in combating cancer metastasis.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Oncology
Tian Zhan et al.
Summary: The study identified a novel lncRNA SNHG3/miR-214-3p/ASF1B axis that could promote the recurrence of HCC by regulating immune infiltration. Highly expressed genes including SNHG3, LINC00205, ASF1B, AURKB, CCNB1, CDKN3, and DTL were found to be closely associated with HCC grade and stage, and correlated with poor disease-free survival. The ASF1B gene, negatively regulated by miR-214-3p and influenced by SNHG3, was also positively correlated with immune infiltration in HCC patients.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Ru Sun et al.
Summary: Exosomes, small extracellular vesicles ranging from 30-150 nm, are crucial in cell-to-cell communication by transferring biological information like DNA, RNA, and proteins. Recent findings indicate that exosomes can carry long non-coding RNAs (lncRNAs), impacting the progression of colorectal cancer significantly.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Xue Dong et al.
Summary: The study utilized exosomes (EXOs) as carriers for delivering the anti-angiogenic peptide KV11 via retro-orbital injection, showing enhanced suppression of neovascularization and vascular leakage in the retina. This system has the potential to treat proliferative retinopathy in a less invasive manner compared to intravitreal injection.
Review
Oncology
Chuanshi He et al.
Summary: The article reviews the role of exosome-mediated interactions between cells under radiotherapy conditions, highlighting the importance of exosomes in the tumor microenvironment and the rebuilding of regulatory processes under radiation stimulation.
CANCER BIOLOGY & MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Pei Xu et al.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2020)
Review
Nanoscience & Nanotechnology
Victor C. Kok et al.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Article
Cell Biology
Lucio Diaz-Flores et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Rongkun Li et al.
Article
Cell Biology
Ye-Fen Lu et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2018)
Review
Oncology
Mihnea Dragomir et al.
TRANSLATIONAL CANCER RESEARCH
(2018)
