期刊
CANCER DISCOVERY
卷 13, 期 1, 页码 14-16出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/2159-8290.CD-22-1212
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Mutant p53 proteins are found in various human cancers. In this study, Guiley and Shokat report on the development of compounds that can restore the function of Y220C mutant p53 protein by covalently binding to it.
p53 mutant proteins are widely expressed in human cancer. In this issue, Guiley and Shokat describe the development of compounds that rescue the function of the Y220C mutant p53 protein by forming covalent complexes with the target protein.
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