期刊
BMC PREGNANCY AND CHILDBIRTH
卷 23, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12884-023-05364-4
关键词
Psoriatic arthritis; Ankylosing spondylitis; Maternal interleukin-17; Pregnancy outcomes
This study aimed to evaluate the impact of maternal interleukin-17A and disease activity on pregnancy outcomes in Psoriatic arthritis (PsA) and ankylosing spondylitis (AS) patients. The results showed that PsA and AS patients were more prone to preterm labor, oligohydramnios, caesarean delivery, and delivering infants small for gestational age. There was a significant difference in IL-17A levels between the study group and the control group.
ObjectiveWe aimed in this study to evaluate the impact of maternal interleukin -17A and the activity of the illness on pregnancy outcomes in Psoriatic arthritis (PsA) and ankylosing spondylitis (AS) patients.MethodsThis prospective cohort research was carried out on 48 Psoriatic arthritis and ankylosing spondylitis pregnant women attending the inpatient and outpatient clinics of the Rheumatology & Rehabilitation and Obstetrics & Gynecology Departments, Faculty of Medicine, Zagazig University Hospitals in Egypt and 30 apparently healthy age- and sex-matched pregnant women between January 1,2018, and December 31, 2019.ResultsThe study group patients had a higher risk of preterm labour (32-36 weeks gestation) (aRR 1.80, 95% CI 0.79-4.17), oligohydramnios (aRR 3.15, 95% CI 1.26-8.42), Caesarean delivery (aRR 1.57, 95% CI 1.41-2.68), and delivering infants small for gestational age (aRR 7.04, 95% CI 2.36-12.42). There was significant difference between the control group and the study groups regarding the level of IL-17A.ConclusionMany females with PsA and AS have uninhibited pregnancy with regard to adverse events, but in comparison with normal pregnancies particularly with high IL-17A during the third trimester we noticed a growing risk of preterm labour, oligohydramnios and cesarean section. Further studies are needed to evaluate high maternal IL-17A levels and fetal outcomes.
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