Green synthesis of plant-stabilized Au nanoparticles for the treatment of gastric carcinoma

In this study, gold nanoparticles (AuNPs) were green synthesized using plant extract. The obtained nanoparticles (Au NPs) were characterized by advanced physical and chemical tech-niques like TEM, FTIR, UV-vis, SEM, XRD and EDX. SEM image displayed the quasi-spherical shaped nanoparticles of mean diameter 20-50 nm. All the particles were of uniform shape and tex-ture. From the XRD pattern, four distinct diffraction peaks at 38.2 degrees, 44.2 degrees, 64.7 degrees and 77.4 degrees are indexed as (1 1 1), (200), (220) and (31 1) planes of fcc metallic gold. The in vitro cytotoxic and anti-gastric carcinoma effects of biologically synthesized Au NPs against cancer cell lines were assessed. The IC50 of the Au NPs were 192, 149, 76 and 85 mg/mL against NCI-N87, MKN45, GC1401 and GC1436 gastric cancer cell lines. The anti-gastric carcinoma properties of the Au NPs could significantly remove the cancer cell lines in a time and concentration-dependent manner. So, the findings of the recent research show that biologically synthesized Au NPs might be used to cure cancer.(c) 2022 Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Automated summary

In this study, gold nanoparticles (AuNPs) were synthesized using plant extract and characterized by physical and chemical techniques. The quasi-spherical nanoparticles of mean diameter 20-50 nm were observed through SEM imaging. The XRD pattern confirmed the metallic gold composition of the nanoparticles. The biologically synthesized AuNPs showed cytotoxic and anti-gastric carcinoma effects against cancer cell lines, indicating their potential in cancer treatment.