期刊
ACS CATALYSIS
卷 12, 期 24, 页码 15590-15599出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.2c04959
关键词
C-N coupling; ammonium salt; primary amines; aryl halides; nickel catalysis
资金
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities
- 111 project
- [22171174]
- [21871171]
- [GK202001001]
- [GK202007021]
- [GK202207015]
- [B14041]
This study demonstrates an easy, efficient, and economic method for synthesizing anilines. By directly exciting light, the amination of aryl halides with ammonium salts can be catalyzed using a Ni(OAc)2-bipyridine complex, allowing a broad range of aryl chlorides and bromides to be converted into primary (hetero)arylamines without the need for an external photosensitizer. The photoinduced generation of Ni(I)-bipyridine species is believed to play a key role in this catalytic cycle.
Easy, efficient, and economic synthesis of anilines remains an important challenge in synthetic chemistry. In this study, a Ni(OAc)2-bipyridine complex is shown to readily catalyze the amination of aryl halides with ammonium salts under direct excitation of light, allowing a broad array of aryl chlorides and bromides to be converted into the corresponding primary (hetero)arylamines in the absence of an external photosensitizer. Late-stage modification of drug molecules and 15N-labeling of primary aryl amines are also demonstrated with a number of examples. Photoinduced generation of Ni(I)-bipyridine species is believed to be the key step in the reaction, enabling a Ni(I)/Ni(III) cycle for catalytic turnover.
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