期刊
ACS CATALYSIS
卷 13, 期 1, 页码 744-748出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.2c05438
关键词
Dicarbofunctionalization; Cross-Electrophile; Annulation; Cobalt; Indane
Here, a cobalt-catalyzed asymmetric reductive 1,2-dicarbofunctionalization of 1,3-dienes using obromoaryl imines as a bis-electrophilic coupling partner is reported. This method provides a pathway to prepare disubstituted cis-indanes in high diastereo- and enantioselectivities under mild reaction conditions. The proposed reaction mechanism includes enantioselective intermolecular migratory insertion and diastereoselective intramolecular allylation as the key elementary steps.
Herein, we report a cobalt-catalyzed asymmetric reductive 1,2-dicarbofunctionalization of 1,3-dienes employing obromoaryl imines as a bis-electrophilic coupling partner. This method provides an entry to prepare disubstituted cis-indanes in high diastereo- and enantioselectivities under mild reaction conditions. The proposed reaction mechanism consists of enantioselective intermolecular migratory insertion and diastereoselective intramolecular allylation as the key elementary steps.
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