期刊
NATURE COMMUNICATIONS
卷 13, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41467-022-35101-y
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资金
- Centre National de la Recherche Scientifique
- Ile-de-France Regional Council
- Inserm
- Institut Curie
- Universite Paris Cite
- PNREST Anses [ANSES-21-RF-24]
- ANR [ANR-20-CE13-0012]
- Agence Nationale de la Recherche (ANR) [ANR-20-CE13-0012] Funding Source: Agence Nationale de la Recherche (ANR)
Association genetic studies and genome-scale CRISPR screens have identified ARF3 and TMEM251/LYSET/GCAF as Golgi-resident factors essential for brain and skeletal development. The consequences of mutations in these genes affect endosomal and lysosomal compartments, but the problem originates in the Golgi complex and may involve the identity of carrier vesicles or cargo molecules.
Association genetic studies and genome-scale CRISPR screens have recently identified ARF3 and TMEM251/LYSET/GCAF as Golgi-resident factors essential to brain and skeletal development. Here we discuss how even though the consequences of mutations in these genes affect endosomal and lysosomal compartments, the problem originates in the Golgi complex and may involve either the identity of the carrier vesicles or that of cargo molecules.
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