期刊
NATURE COMMUNICATIONS
卷 13, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41467-022-35294-2
关键词
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资金
- National Natural Science Foundation of China [T2221004, 81930125, 82273787, 82130104]
- 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University [ZYGD18001, ZYXY21001]
In this study, a new non-classical ferroptosis inhibitor YL-939 was discovered, which binds to PHB2 and promotes the expression of ferritin, thereby reducing iron content and decreasing susceptibility to ferroptosis. The authors also showed that YL-939 can ameliorate liver damage in an acute liver injury model by targeting the PHB2/ferritin/iron axis. These findings reveal a new regulation mechanism of ferroptosis and present an attractive intervention strategy for ferroptosis-related diseases.
Ferroptosis is a new type of programmed cell death characterized by iron-dependent lipid peroxidation. Ferroptosis inhibition is thought as a promising therapeutic strategy for a variety of diseases. Currently, a majority of known ferroptosis inhibitors belong to either antioxidants or iron-chelators. Here we report a new ferroptosis inhibitor, termed YL-939, which is neither an antioxidant nor an iron-chelator. Chemical proteomics revealed the biological target of YL-939 to be prohibitin 2 (PHB2). Mechanistically, YL-939 binding to PHB2 promotes the expression of the iron storage protein ferritin, hence reduces the iron content, thereby decreasing the susceptibility to ferroptosis. We further showed that YL-939 could substantially ameliorate liver damage in a ferroptosis-related acute liver injury model by targeting the PHB2/ferritin/iron axis. Overall, we identified a non-classical ferroptosis inhibitor and revealed a new regulation mechanism of ferroptosis. These findings may present an attractive intervention strategy for ferroptosis-related diseases. Ferroptosis is a promising therapeutic target for a variety of diseases, but a majority of known ferroptosis inhibitors belong to either antioxidants or iron chelators. Here, the authors discover a new non-classical small molecule inhibitor that is a PHB2 binder and show it ameliorates liver damage in an acute liver injury model.
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