期刊
NATURE COMMUNICATIONS
卷 13, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41467-022-35474-0
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资金
- National Key R&D Program of China-the Sci Tech Innovation 2030 Major Project [2021ZD0203100]
- National Natural Science Foundation of China [81971038, 82171235, 81870891, 82071231, 82271293, 82293641, 82130033]
- Natural Science Foundation of Jiangsu Province [BK20211349]
- Leadership Program in Xuzhou Medical University [JBGS202203]
- Postgraduate Innovation Program in Jiangsu Province [KYCX22_2936, KYCX22_2952]
- Fund for Jiangsu Province Specially-Appointed Professor
The SNr(GABA)-STNGlu-LPBGlu pathway regulates acute and persistent pain states and is a potential target for pain management.
The basal ganglia including the subthalamic nucleus (STN) and substantia nigra pars reticulata (SNr) are involved in pain-related responses, but how they regulate pain processing remains unknown. Here, we identify a pathway, consisting of GABAergic neurons in the SNr (SNr(GABA)) and glutamatergic neurons in the STN (STNGlu) and the lateral parabrachial nucleus (LPBGlu), that modulates acute and persistent pain states in both male and female mice. The activity of STN neurons was enhanced in acute and persistent pain states. This enhancement was accompanied by hypoactivity in SNr(GABA) neurons and strengthening of the STN-LPB glutamatergic projection. Reversing the dysfunction in the SNr(GABA)-STNGlu-LPBGlu pathway attenuated activity of LPBGlu neurons and mitigated pain-like behaviors. Therefore, the SNr(GABA)-STNGlu-LPBGlu pathway regulates pathological pain and is a potential target for pain management.
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