4.8 Article

An enantioselective four-component reaction via assembling two reaction intermediates

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NATURE COMMUNICATIONS
卷 13, 期 1, 页码 -

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NATURE PORTFOLIO
DOI: 10.1038/s41467-022-34913-2

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资金

  1. Guangdong Innovative and Entrepreneurial Research Team Program [2016ZT06Y337]
  2. National Natural Science Foundation of China [92056201]
  3. NSFC [21801255]
  4. Fundamental Research Funds for the Central Universities [020514380253, 020514380277]
  5. Natural Science Foundation of Jiangsu Province [BK20211555]
  6. Jiangsu Innovation & Entrepreneurship Talents Plan

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This article reports various highly diastereoselective and enantioselective four-component reactions. The trapping strategy used in this work allows for the generation of a wide range of reaction products under mild conditions, showing high functional group tolerance. The proposed mechanism of this multicomponent reaction is also discussed.
A reaction intermediate is a key molecular entity that has been used in explaining how starting materials converts into the final products in the reaction, and it is usually unstable, highly reactive, and short-lived. Extensive efforts have been devoted in identifying and characterizing such species via advanced physico-chemical analytical techniques. As an appealing alternative, trapping experiments are powerful tools in this field. This trapping strategy opens an opportunity to discover multicomponent reactions. In this work, we report various highly diastereoselective and enantioselective four-component reactions (containing alcohols, diazoesters, enamines/indoles and aldehydes) which involve the coupling of in situ generated intermediates (iminium and enol). The reaction conditions presented herein to produce over 100 examples of four-component reaction products proceed under mild reaction conditions and show high functional group tolerance to a broad range of substrates. Based on experimental and computational analyses, a plausible mechanism of this multicomponent reaction is proposed. The interception of one chemical intermediate with another intermediate is very challenging, as intermediates may be incompatible or too reactive, but could result in a streamlined method of organic synthesis. Here, the authors demonstrate enantioselective four-component reactions via the coupling of two intermediates.

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