VHL-HIF-2α axis-induced SEMA6A upregulation stabilized β-catenin to drive clear cell renal cell carcinoma progression

Article Oncology

Wnt signaling pathway in cancer immunotherapy

Yang Zhou et al.

Summary: Abnormal activation of the Wnt/beta-catenin signaling pathway is closely related to tumorigenesis and immune surveillance, leading to increased resistance to immunotherapy.

CANCER LETTERS (2022)

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Article Cell Biology

Deubiquitylase OTUD6B stabilizes the mutated pVHL and suppresses cell migration in clear cell renal cell carcinoma

Kai Guo et al.

Summary: OTUD6B plays an important role in regulating the stability of pVHL missense mutants in ccRCC. Low levels of OTUD6B predict poorer survival in ccRCC patients with VHL missense mutations, and depletion of OTUD6B enhances cell migration and HIF-2α levels in ccRCC cells.

CELL DEATH & DISEASE (2022)

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Review Urology & Nephrology

Complementary roles of surgery and systemic treatment in clear cell renal cell carcinoma

Alexandre Ingels et al.

Summary: The standard treatment for renal cell carcinoma relies on surgery for low-risk localized tumors and systemic treatment for poor-prognosis metastatic disease. However, there is a grey area for the treatment of high-risk localized tumors and metastatic disease with a good-to-intermediate prognosis. Recent practice-changing trials have transformed the therapeutic options for metastatic renal cell carcinoma. Treatments targeting vascular endothelial growth factor have been the mainstay, but immune checkpoint inhibitors have revolutionized the treatment landscape. The potential benefits of these therapies in the neoadjuvant and adjuvant settings have been investigated. The role of surgery for metastatic disease has been redefined, and there is growing interest in deferred surgery for residual tumors or metastases after checkpoint inhibitor treatment.

NATURE REVIEWS UROLOGY (2022)

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Article Cell Biology

FBXO2 targets glycosylated SUN2 for ubiquitination and degradation to promote ovarian cancer development

Jing Ji et al.

Summary: The study reveals that FBXO2 acts as an E3 ubiquitin ligase and promotes the degradation of SUN2 protein, which is associated with worse prognosis in ovarian cancer. The transcription factor SOX6 enhances the expression of FBXO2 by recognizing a response element on its promoter. Abnormally high expression of FBXO2 leads to degradation of SUN2 protein, promoting cell proliferation and ultimately contributing to the progression of ovarian cancer.

CELL DEATH & DISEASE (2022)

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Review Peripheral Vascular Disease

Arterial Stiffness and the Canonical WNT/β-catenin Pathway

Alexandre Vallee

Summary: This review focuses on the role of the WNT/beta-catenin pathway in the development of arterial stiffness.

CURRENT HYPERTENSION REPORTS (2022)

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Review Oncology

New Therapeutic Interventions for Kidney Carcinoma: Looking to the Future

Lucio Dell'Atti et al.

Summary: The treatment of metastatic renal cell carcinoma is challenging and lethal. Research on new therapeutic options is crucial to improve the quality of life and overall survival of patients. Recent scientific research has identified new signaling pathways and biological processes involved in kidney cancer, which could be potential targets for future treatments.

CANCERS (2022)

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Article Oncology

Circular RNA circ-TNPO3 inhibits clear cell renal cell carcinoma metastasis by binding to IGF2BP2 and destabilizing SERPINH1 mRNA

Xiaojuan Pan et al.

Summary: This study found that circ-TNPO3 is downregulated in ccRCC and its expression level is associated with prognosis in ccRCC patients. Further experiments demonstrated that circ-TNPO3 can inhibit the proliferation and migration of ccRCC cells and uncovered the underlying molecular mechanism. This study provides a potential new target for ccRCC treatment.

CLINICAL AND TRANSLATIONAL MEDICINE (2022)

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Article Multidisciplinary Sciences

USP13 promotes deubiquitination of ZHX2 and tumorigenesis in kidney cancer

Haibiao Xie et al.

Summary: This study reveals that USP13 plays a role in promoting tumorigenesis in ccRCC by deubiquitinating and stabilizing ZHX2. Depletion of USP13 decreases ZHX2 levels and inhibits cell proliferation in ccRCC. These findings suggest that USP13 may be a key factor in ccRCC tumorigenesis.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

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Review Immunology

Roles of the Dynamic Tumor Immune Microenvironment in the Individualized Treatment of Advanced Clear Cell Renal Cell Carcinoma

Enyu Lin et al.

Summary: Immune checkpoint inhibitors are a first-line treatment option for ccRCC, but many patients do not respond to them, even with combination therapy. Studies have shown that the tumor immune microenvironment (TIME) plays a crucial role in the response to immunotherapy and targeted therapy in ccRCC patients, which can be influenced by targeted therapy and tumor genomic characteristics.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Oncology

Sec62 promotes stemness and chemoresistance of human colorectal cancer through activating Wnt/β-catenin pathway

Xiaofeng Liu et al.

Summary: In this study, Sec62 was identified as a novel chemoresistance-related target in colorectal cancer, with upregulation associated with poor patient outcomes. Sec62 was found to promote stemness in CRC cells through activating the Wnt signaling pathway. This study provides insights into potential therapeutic targets for improving treatment outcomes in colorectal cancer.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Oncology

Immunological perspective on the malignant progression of renal clear cell carcinoma

Ji Liu et al.

Summary: The study established an IRGPS based on eight prognostic IRGs, closely associated with immune levels, metastasis, and prognosis. The IRGPS was determined to be a valid predictor of the efficacy of ICIs, and three Nomograms developed could effectively predict prognosis, distant metastasis, and lymph node metastasis in patients with ccRCC.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

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Review Oncology

The Wnt signaling pathway in tumorigenesis, pharmacological targets, and drug development for cancer therapy

Zhuo Wang et al.

Summary: Wnt signaling plays important roles in tissue development, homeostasis maintenance, tumorigenesis, and cancer progression. Abnormal expression of signaling components is associated with tumor progression and poor prognosis, and the pathway also influences the tumor microenvironment and immune response. Drugs targeting the Wnt pathway offer multiple therapeutic values.

BIOMARKER RESEARCH (2021)

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Review Oncology

Hypoxia-Inducible Factor-2α as a Novel Target in Renal Cell Carcinoma

Won Seok W. Choi et al.

Summary: HIF-2 alpha is considered a promising therapeutic target for ccRCC, with inhibitors showing encouraging efficacy and safety in clinical trials.

JOURNAL OF KIDNEY CANCER AND VHL (2021)

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Article Cell Biology