期刊
JOURNAL OF FUNCTIONAL FOODS
卷 99, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jff.2022.105303
关键词
Daucus carota L; Immunomodulator; Oxidative stress; Inflammation; Bioactive compound
资金
- Directorate General of Higher Education Institutions Ministry of Education, Culture, Research, and Technology of Indonesia's Ministry of Education, Culture, Research, and Technology [3077/E3/PKS.08/KL/2021]
- Diponegoro University [3077/E3/PKS.08/KL/2021]
Carrots are rich in bioactive compounds that have immunomodulatory effects, contributing to their health benefits. They regulate immune response through anti-inflammatory, antioxidant, and overall immune response modulation mechanisms.
Carrots (Daucus carota L.) are vegetables proven to have nutraceutical effects and beneficial for health due to its natural bioactive substances. One of the potential of carrots to maintain optimum health status is by regulating immune response. This literature review summarized the proposed immunomodulatory mechanisms of the antioxidant properties of carrot's beta-carotene and other bioactive compounds such as phenolic acid, flavonoid, polyacetylene and ascorbic acid via the anti-inflammatory, antioxidant and overall (innate and adaptive) im-mune response modulation. Overall, carrot's bioactive compounds regulated pro-inflammatory and anti-inflammatory cytokines, reduced oxidative stress by decreasing the reactive oxygen species accumulation and improving antioxidant capacity and the expression of genes in order to prevent more damaging oxidative destruction. Carrots also modulated the immune components by regulating leukocytes, antigens, immunoglob-ulins, and histamine levels. Thus, the immunomodulatory activity makes carrots as a functional food source that has the potential to prevent and treat various diseases.
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