期刊
BMC NEPHROLOGY
卷 23, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12882-022-03036-7
关键词
Catheter exit site infection; Clinical trial; Peritoneal Dialysis patients; Peritonitis; Propolis
资金
- Semnan University of Medical Sciences [1520]
This study aimed to investigate the effect of propolis on the incidence of catheter exit site infection and peritonitis in peritoneal dialysis patients. The results showed that the intervention group using propolis had lower rates of catheter exit site infection and peritonitis compared to the control and placebo groups, with no significant differences observed among the three groups.
Background: Peritonitis is one of the major complications of peritoneal dialysis. The most common cause of peritonitis is infection at the catheter exit site. This study aimed to determine the effect of propolis on the incidence of catheter exit site infection and peritonitis in peritoneal dialysis patients. Method: This study was a double-blind clinical trial (2019-2020) with peritoneal dialysis patients. Ninety peritoneal dialysis patients were allocated to three groups (placebo, control, intervention) using block randomization method. Catheter exit site was washed with 0.9% normal saline and dressing was done every other day after the morning peritoneal dialysis exchange by use of normal saline in placebo, mupirocin in control, and propolis in intervention group, for 6 months. Discussion: 10% of the patients in the placebo and 6.7% in the control group developed catheter Exit Site Infection, but none patient in the intervention group developed this infection (P = 0.469). Whereas 6.7% in both the placebo and control groups developed peritonitis, but none patient in the intervention group contracted peritonitis (P = 0.997). No significant differences in the incidence of catheter exit site infection and peritonitis among the three groups were observed. Considering that mupirocin is of chemical origin and may lead to drug resistance whereas propolis is of plant origin and does not produce drug resistance, the use of propolis is recommended.
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