期刊
JOURNAL OF PHYSICS D-APPLIED PHYSICS
卷 49, 期 27, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/0022-3727/49/27/274004
关键词
carbon nanowalls; biocompatibility; osteoblast; proliferation
资金
- Romanian Executive Unit for Financing Higher Education, Research, Development and Innovation [PCCA 253/2014]
The response of MC3T3-E1 pre-osteoblasts to vertically aligned, interconnected carbon nanowalls prepared by plasma enhanced chemical vapor deposition on silicon substrate has been evaluated in terms of cell adhesion, viability and cell proliferation. The behavior of osteoblasts seeded on carbon nanowalls was analyzed in parallel and compared with the behavior of the cells maintained in contact with tissue culture polystyrene (TCPS). The results demonstrate that osteoblasts adhere and remain viable in the long term on carbon nanowalls. Moreover, on the investigated scaffold cell proliferation was significantly promoted, although to a lower extent than on TCPS. Overall, the successful culture of osteoblasts on carbon nanowalls coated substrate confirms the biocompatibility of this scaffold, which could have potential applications in the development of orthopedic biomaterials.
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