Cellular miR-6741-5p as a Prognostic Biomarker Predicting Length of Hospital Stay among COVID-19 Patients

Article Endocrinology & Metabolism

Ppt1-deficiency dysregulates lysosomal Ca++ homeostasis contributing to pathogenesis in a mouse model of CLN1 disease

Avisek Mondal et al.

Summary: This study reveals a previously unknown role of Ppt1 in regulating lysosomal calcium homeostasis and suggests that this defect may contribute to the pathogenesis of CLN1 disease.

JOURNAL OF INHERITED METABOLIC DISEASE (2022)

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Article Biochemistry & Molecular Biology

Differential Activity of APOBEC3F, APOBEC3G, and APOBEC3H in the Restriction of HIV-2

Morgan E. Meissner et al.

Summary: This study comprehensively characterized the restrictive capacity of A3 proteins against HIV-2 and found that A3F, A3G, and A3H can inhibit HIV-2 infectivity and increase the frequency of viral mutations, while A3D does not exhibit this restrictive activity.

JOURNAL OF MOLECULAR BIOLOGY (2022)

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Article Biochemistry & Molecular Biology

Cellular miR-150-5p may have a crucial role to play in the biology of SARS-CoV-2 infection by regulating nsp10 gene

S. M. Akula et al.

Summary: The role of circulating miRNAs as biomarkers for COVID-19 remains uncertain. However, analysis of circulating miRNA profiles in COVID-19 patients revealed significant changes, with miR-150-5p potentially playing a crucial role in SARS-CoV-2 infection. Further investigation into the mechanism by which COVID-19-induced changes in miR-150-5p levels may promote SARS-CoV-2 infection is warranted.

RNA BIOLOGY (2022)

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Article Cell Biology

Predicting the mutational drivers of future SARS-CoV-2 variants of concern

M. Cyrus Maher et al.

Summary: This study predicts future variants of SARS-CoV-2 by analyzing various factors affecting its evolution, including ACE2-mediated transmissibility and host immunity. The researchers successfully identified mutations that will emerge in different phases of the pandemic and assessed their impact on therapeutic antibodies. This modeling approach has important implications for predicting emerging variants of SARS-CoV-2 and can be applied to other rapidly evolving pathogens.

SCIENCE TRANSLATIONAL MEDICINE (2022)

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Article Gastroenterology & Hepatology

Gastrointestinal post-acute COVID-19 syndrome

Hadar Meringer et al.

Summary: The definition, frequency, and pathophysiology of gastrointestinal involvement in post-acute COVID-19 syndrome are not fully understood. This article discusses emerging evidence that supports immunological signatures and highlights the unique nature of the gastrointestinal tract in this syndrome.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2022)

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Article Medicine, General & Internal

Cardiovascular signatures of COVID-19 predict mortality and identify barrier stabilizing therapies

Dakota Gustafson et al.

Summary: This study prospectively evaluated circulating inflammatory, cardiac, and endothelial cell activation markers in COVID-19 patients and identified microRNA and vascular biomarkers that are prognostic of in-hospital mortality. The study also found that COVID-19 patient plasma can cause endothelial barrier dysfunction, which can be improved with therapeutic interventions.

EBIOMEDICINE (2022)

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Review Medicine, General & Internal

Current Trends in Circulating Biomarkers for Melanoma Detection

Nancy Huang et al.

Summary: Melanoma is the leading cause of skin cancer deaths, and liquid biomarkers have advantages in monitoring tumor burden and heterogeneity. The only serological marker currently used, lactate dehydrogenase, is not specific or sensitive enough. This review summarizes the current research on liquid biomarkers, including circulating tumor cells, circulating tumor DNA, microRNA, and extracellular vesicles.

FRONTIERS IN MEDICINE (2022)

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Article Clinical Neurology

Post-COVID-19 neuropsychiatric manifestations among COVID-19 survivors suffering from migraine: a case-control study

Rehab Magdy et al.

Summary: This study investigated the post-COVID-19 neuropsychiatric symptoms in migraine patients compared to a non-migraine control group. The findings suggest that migraine patients may be more vulnerable to experiencing symptoms such as fatigue, anosmia/hyposmia, anxiety, and headache after recovering from COVID-19. This highlights the importance of closely monitoring and caring for migraine patients during their recovery.

JOURNAL OF HEADACHE AND PAIN (2022)

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Review Biology

COVID-19 Vaccine and Long COVID: A Scoping Review

Aqsa Mumtaz et al.

Summary: This study describes the pathophysiology of long COVID and discusses different therapeutic agents. It also evaluates the comparative efficacy of different vaccines on symptoms of long COVID.

LIFE-BASEL (2022)

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Article Allergy

The long COVID syndrome: A conundrum for the allergist/ immunologist

Joseph A. Bellanti

Summary: Long COVID refers to a group of patients who experience lingering mild-to-moderate symptoms and develop long-term health problems after infection with SARS-CoV-2. These patients may have physical and mental health symptoms similar to those seen in ME/CFS patients, and chronic inflammation is considered one of the major causes. Long COVID is a growing burden for patients, healthcare providers, and healthcare systems, and poses a particular challenge for allergists/immunologists.

ALLERGY AND ASTHMA PROCEEDINGS (2022)

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Review Urology & Nephrology

Post-acute COVID-19 syndrome and kidney diseases: what do we know?

Sidar Copur et al.

Summary: COVID-19 can affect the kidneys, causing various symptoms not only during the acute phase but also in the post-infection period. Chronic kidney disease and acute kidney injury are associated with high mortality and morbidity rates. Additionally, some patients may experience a decline in renal function even without signs of acute kidney injury during the acute phase.

JOURNAL OF NEPHROLOGY (2022)

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Article Virology

Potential APOBEC-mediated RNA editing of the genomes of SARS-CoV-2 and other coronaviruses and its impact on their longer term evolution

Jeremy Ratcliff et al.

Summary: Members of the APOBEC family exhibit antiviral activities in mammalian cells through lethal editing of the genomes of various viruses, including RNA viruses like coronaviruses. APOBEC-like C-*U transitions are significantly overrepresented in the SARS-CoV-2 genome sequences during the COVID-19 pandemic, which may leave evolutionary imprints on coronavirus genomes. This process may lead to homoplasy and amino acid sequence changes in viral proteins, potentially explaining global depletion of C and excess of U bases in human seasonal coronavirus genomes.

VIROLOGY (2021)

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Article Biochemical Research Methods

The miRNA: a small but powerful RNA for COVID-19

Song Zhang et al.

Summary: This article summarizes the role of miRNA in COVID-19 infection and suggests that COVID-19 cleverly exploits the interaction between miRNA and other biomolecules to evade host immune response. The study proposes that the miRNA-based interplay between the host and SARS-CoV-2 may be the primary cause of SARS-CoV-2 accessing and attacking host cells.

BRIEFINGS IN BIOINFORMATICS (2021)

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Article Infectious Diseases

Long-term sero-positivity for IgG, sequelae of respiratory symptoms, and abundance of malformed sperms in a patient recovered from severe COVID-19

Mingchao Zhu et al.

Summary: Patients with severe COVID-19 pneumonia may have respiratory sequelae, significantly increased abnormal sperm rate, and prolonged IgG positivity.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2021)

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Article Biochemistry & Molecular Biology

Lung expression of genes putatively involved in SARS-CoV-2 infection is modulated in cis by germline variants

Chiara E. Cotroneo et al.

Summary: Germline variants in genes involved in SARS-CoV-2 cell entry and host innate immune responses may impact susceptibility to infection. This study identified cis-eQTLs regulating the expression of 15 genes relevant to viral entry and host antiviral responses in lung tissue, suggesting a genetic basis for interindividual differences in infection risk or severity.

EUROPEAN JOURNAL OF HUMAN GENETICS (2021)

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Article Biochemistry & Molecular Biology

Attributes and predictors of long COVID

Carole H. Sudre et al.

Summary: Reports on long-lasting COVID-19 symptoms, known as 'long COVID', are increasing. Analysis of data from over 4,000 COVID-19 cases revealed that long COVID is more common in older individuals, those with higher body mass index, and females. Experiencing more than five symptoms in the first week of illness was associated with long COVID. A simple model showed promise in distinguishing between short and long COVID cases early in the disease.

NATURE MEDICINE (2021)

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Article Emergency Medicine

Inflammatory markers are poorly predictive of clinical outcomes among hospitalized patients with COVID-19

Brendan Barrett et al.

Summary: Inflammatory markers drawn within 48 h of arrival are correlated with clinical outcomes in COVID-19 patients, but are not highly predictive of death or the need for intubation, renal replacement therapy, or ICU admission in a predominantly older and minority population.

AMERICAN JOURNAL OF EMERGENCY MEDICINE (2021)

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Article Mathematics, Interdisciplinary Applications

A Guide for Sparse PCA: Model Comparison and Applications

Rosember Guerra-Urzola et al.

Summary: PCA is commonly used for exploring and summarizing multivariate data, however, interpreting the components can be challenging due to the linear combination of variables. Various methods have been proposed to sparsify the nonzero coefficients in the components, including rotation-thresholding methods and PCA methods with sparsity inducing penalties or constraints. This study provides guidelines on how to choose among different sparse PCA methods, evaluating their properties and performance through simulation studies and empirical data examples.

PSYCHOMETRIKA (2021)

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Article Oncology

Decreased TMEM40 expression is associated with malignant behavior of cutaneous squamous cell carcinoma and inhibits tumor progression

Lei Yu et al.

Summary: In this study, increased TMEM40 expression was found in CSCC tissue samples compared to normal skin, and was associated with large tumor size in CSCC patients. Functional assays in vitro demonstrated that TMEM40 was involved in regulating cell growth in A431 and SCL1 cells by affecting the cell cycle and apoptosis. Silencing TMEM40 in these cells resulted in cell cycle arrest and increased apoptosis. Additionally, migration and invasion were significantly reduced after silencing TMEM40 expression in CSCC cells. These findings suggest that targeting TMEM40 could potentially inhibit CSCC development and serve as a therapeutic target for CSCC.

ONCOLOGY LETTERS (2021)

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Review Infectious Diseases

Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments

Shin Jie Yong

Summary: Long COVID or post-COVID-19 syndrome is a poorly understood condition that affects survivors with symptoms like fatigue, dyspnoea, cognitive impairments, and more. The pathophysiology, risk factors, and treatments are still lacking in literature, but potential treatments may include rehabilitation training and repurposed drugs from similar conditions. Further research is needed to substantiate risk factors and treatment options.

INFECTIOUS DISEASES (2021)

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Article Endocrinology & Metabolism

Long COVID: An overview

A. V. Raveendran et al.

Summary: Long COVID refers to the persistence of symptoms in individuals who have recovered from SARS-CoV-2 infection, possibly related to organ damage, post viral syndrome, etc. Clinical evaluation should focus on identifying the pathophysiology and appropriate remedial measures.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2021)

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Article Biochemistry & Molecular Biology

miRDB: an online database for prediction of functional microRNA targets

Yuhao Chen et al.

NUCLEIC ACIDS RESEARCH (2020)

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Review Virology

The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients

Yan-Chao Li et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

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Article Immunology

Tob2 Inhibits TLR-Induced Inflammatory Responses by Association with TRAF6 and MyD88

Guosheng Jiang et al.

JOURNAL OF IMMUNOLOGY (2020)

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Review Medicine, General & Internal

COVID-19 length of hospital stay: a systematic review and data synthesis

Eleanor M. Rees et al.

BMC MEDICINE (2020)

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Review Biochemistry & Molecular Biology

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): a review

Wei Feng et al.

MOLECULAR CANCER (2020)

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Article Multidisciplinary Sciences

Principal component analysis of blood microRNA datasets facilitates diagnosis of diverse diseases

Stacy L. Sell et al.

PLOS ONE (2020)

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Article Respiratory System

C-reactive protein, procalcitonin, D-dimer, and ferritin in severe coronavirus disease-2019: a meta-analysis

Ian Huang et al.

THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE (2020)

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Article Biochemical Research Methods

INDRA-IPM: interactive pathway modeling using natural language with automated assembly

Petar V. Todorov et al.

BIOINFORMATICS (2019)

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Article Virology

Flexibility in Nucleic Acid Binding Is Central to APOBEC3H Antiviral Activity

Jennifer A. Bohn et al.

JOURNAL OF VIROLOGY (2019)

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Article Biotechnology & Applied Microbiology

Prediction of functional microRNA targets by integrative modeling of microRNA binding and target expression data

Weijun Liu et al.

GENOME BIOLOGY (2019)

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Article Medicine, Research & Experimental

ASK1/2 signaling promotes inflammation in a mouse model of neutrophilic dermatosis

Sarang Tartey et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

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Article Biochemistry & Molecular Biology

The Antiviral and Cancer Genomic DNA Deaminase APOBEC3H Is Regulated by an RNA-Mediated Dimerization Mechanism

Nadine M. Shaban et al.

MOLECULAR CELL (2018)

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Article Oncology

APOBEC3G Expression Correlates with T-Cell Infiltration and Improved Clinical Outcomes in High-grade Serous Ovarian Carcinoma

Brandon Leonard et al.

CLINICAL CANCER RESEARCH (2016)

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Article Biology

Predicting effective microRNA target sites in mammalian mRNAs

Vikram Agarwal et al.

ELIFE (2015)

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Review Biochemistry & Molecular Biology

Aberrant Regulation and Function of MicroRNAs in Cancer

Brian D. Adams et al.

CURRENT BIOLOGY (2014)

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Article Biochemistry & Molecular Biology

Nicotine-mediated invasion and migration of non-small cell lung carcinoma cells by modulating STMN3 and GSPT1 genes in an ID1-dependent manner

Sajitha Nair et al.

MOLECULAR CANCER (2014)

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Article Genetics & Heredity

Natural Polymorphisms in Human APOBEC3H and HIV-1 Vif Combine in Primary T Lymphocytes to Affect Viral G-to-A Mutation Levels and Infectivity

Eric W. Refsland et al.

PLOS GENETICS (2014)

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Article Multidisciplinary Sciences

Multiple-to-Multiple Relationships between MicroRNAs and Target Genes in Gastric Cancer

Yutaka Hashimoto et al.

PLOS ONE (2013)

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Review Genetics & Heredity

Non-coding RNAs in human disease

Manel Esteller

NATURE REVIEWS GENETICS (2011)

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Article Biochemistry & Molecular Biology

Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells

Nobuyoshi Kosaka et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

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Article Biotechnology & Applied Microbiology

Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites

Doron Betel et al.

GENOME BIOLOGY (2010)

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Article Biochemistry & Molecular Biology

Sole copy of Z2-type human cytidine deaminase APOBEC3H has inhibitory activity against retrotransposons and HIV-1

Lindi Tan et al.

FASEB JOURNAL (2009)

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Article Biochemical Research Methods

Experimental validation of miRNA targets

Donald E. Kuhn et al.

METHODS (2008)

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Review Biotechnology & Applied Microbiology

The AID/APOBEC family of nucleic acid mutators

Silvestro G. Conticello

GENOME BIOLOGY (2008)

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Review Cell Biology

The diverse functions of MicroRNAs in animal development and disease

Wigard P. Kloosterman et al.

DEVELOPMENTAL CELL (2006)

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Article Gastroenterology & Hepatology

Expression of transmembrane 4 superfamily (TM4SF) proteins and their role in hepatic stellate cell motility and wound healing migration

A Mazzocca et al.

JOURNAL OF HEPATOLOGY (2002)

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Cellular miR-6741-5p as a Prognostic Biomarker Predicting Length of Hospital Stay among COVID-19 Patients

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