期刊
VIRUSES-BASEL
卷 14, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/v14122788
关键词
COVID-19; SARS-CoV-2; whole genome sequencing; genomic epidemiology; West Africa; Burkina Faso
类别
资金
- Souro Sanou University Hospital Center
- European Union
- German Ministry of Education and Research [RIA2020EF-3012]
- Solidarity Fund for Innovative [01KA1606]
This study provides a genomic epidemiology of SARS-CoV-2 in Burkina Faso, highlighting the role of cross-border human mobility in the spread of the virus. The findings emphasize the importance of implementing preventive policies and regional cross-border collaborations to prevent new epidemic waves.
Background: After its initial detection in Wuhan, China, in December 2019, SARS-CoV-2 has spread rapidly, causing successive epidemic waves worldwide. This study aims to provide a genomic epidemiology of SARS-CoV-2 in Burkina Faso. Methods: Three hundred and seventy-seven SARS-CoV-2 genomes obtained from PCR-positive nasopharyngeal samples (PCR cycle threshold score < 35) collected between 5 May 2020, and 31 January 2022 were analyzed. Genomic sequences were assigned to phylogenetic clades using NextClade and to Pango lineages using pangolin. Phylogenetic and phylogeographic analyses were performed to determine the geographical sources and time of virus introduction in Burkina Faso. Results: The analyzed SARS-CoV-2 genomes can be assigned to 10 phylogenetic clades and 27 Pango lineages already described worldwide. Our analyses revealed the important role of cross-border human mobility in the successive SARS-CoV-2 introductions in Burkina Faso from neighboring countries. Conclusions: This study provides additional insights into the genomic epidemiology of SARS-CoV-2 in West Africa. It highlights the importance of land travel in the spread of the virus and the need to rapidly implement preventive policies. Regional cross-border collaborations and the adherence of the general population to government policies are key to prevent new epidemic waves.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据