期刊
JOURNAL OF PHYSICS D-APPLIED PHYSICS
卷 49, 期 30, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/0022-3727/49/30/304002
关键词
poly(methyl methacrylate) surfaces; cell adhesion; cell proliferation; oxygen plasma nanotexturing
Poly(methyl methacrylate) surfaces have been micro-nanotextured in oxygen plasmas with increasing ion energy, leading to micro-nanotopography characterized by increased root mean square roughness, correlation length and fractal dimension. Primary human skin fibroblasts and mouse immortalized 3T3 fibroblasts were cultured on these surfaces and the number of adhering cells, their proliferation rate and morphology (cytoplasm and nucleus area) were evaluated as a function of roughness height, correlation length, and fractal dimension. A roughness threshold behavior was observed for both types of cells leading to dramatic cell number decrease above this threshold, which is almost similar for the two types of cells, despite their differences in size and stiffness. The results are discussed based on two theoretical models, which are reconciled and unified when the elastic moduli and the size of the cells are taken into account.
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