期刊
VIRUSES-BASEL
卷 15, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/v15020312
关键词
SARS-CoV-2; Omicron; variants; evolution; South America; dynamics; BA; 1; 2; 4; 5
类别
This study aimed to investigate the dynamics of SARS-CoV-2 Omicron lineages during the third and fourth waves of COVID-19 in Argentina. The third wave was associated with lineage BA.1 and characterized by a high number of cases, rapid displacement of Delta, and low lineage diversity and clustering. In contrast, the fourth wave was longer but had a lower number of cases and was initially caused by BA.2 and later by BA.4/BA.5. Differential dynamics between the waves may be attributed to waning immunity, population gatherings, and boosted population with prior immunity or vaccination.
The COVID-19 pandemic has lately been driven by Omicron. This work aimed to study the dynamics of SARS-CoV-2 Omicron lineages during the third and fourth waves of COVID-19 in Argentina. Molecular surveillance was performed on 3431 samples from Argentina, between EW44/2021 and EW31/2022. Sequencing, phylogenetic and phylodynamic analyses were performed. A differential dynamic between the Omicron waves was found. The third wave was associated with lineage BA.1, characterized by a high number of cases, very fast displacement of Delta, doubling times of 3.3 days and a low level of lineage diversity and clustering. In contrast, the fourth wave was longer but associated with a lower number of cases, initially caused by BA.2, and later by BA.4/BA.5, with doubling times of about 10 days. Several BA.2 and BA.4/BA.5 sublineages and introductions were detected, although very few clusters with a constrained geographical distribution were observed, suggesting limited transmission chains. The differential dynamic could be due to waning immunity and an increase in population gatherings in the BA.1 wave, and a boosted population (for vaccination or recent prior immunity for BA.1 infection) in the wave caused by BA2/BA.4/BA.5, which may have limited the establishment of the new lineages.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据