期刊
VIRUSES-BASEL
卷 15, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/v15010123
关键词
COVID-19; pharmacokinetics; pharmacodynamics; mouse model
类别
Despite vaccination efforts, treatment tools are still necessary for COVID-19. COVID-HIGIV showed significant survival benefit in SARS-CoV-2 infected mice and had similar pharmacokinetic profiles in healthy and infected mice. These findings suggest that early administration of COVID-HIGIV may be an effective treatment for SARS-CoV-2 infection.
Despite ongoing vaccination efforts to prevent SARS-CoV-2 infections, treatment tools are still necessary to address the ongoing COVID-19 pandemic. We report here that COVID-HIGIV, a human immunoglobulin product for treatment of COVID-19, provided a significant survival benefit in SARS-CoV-2 infected transgenic mice compared to controls. COVID-HIGIV also has similar pharmacokinetic profiles in healthy and SARS-CoV-2 infected mice over time after intravenous administration, with identical or comparable Tmax, Cmax, AUC(0-infinity) and Cl. AUC(0-last) increased and mean residence time, T-1/2, and Vd reduced in infected animals compared to healthy animals. These data suggest that COVID-HIGIV may be an effective treatment for SARS-CoV-2 infection when given early after exposure.
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