相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。
Article
Virology
Simone Kashima et al.
Summary: This study characterized the circulation of the SARS-CoV-2 Lambda variant in Sao Paulo State, Brazil. Among approximately 8000 newly sequenced genomes, seven Lambda isolates were identified, with three possibly due to contact transmission. Vaccinated patients showed mild symptoms, while one required hospitalization among those testing positive for Lambda variant.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Biochemical Research Methods
Gabriela Bastos Cabral et al.
Summary: Vaccination and the emergence of SARS-CoV-2 variants in the second year of the pandemic have led to amino acid mutations in the spike region. The authors describe Sanger sequencing protocols that can be used to monitor the evolution of SARS-CoV-2 and new variants.
JOURNAL OF VIROLOGICAL METHODS
(2022)
Article
Immunology
Maria de Fatima Carvalho Ferreira et al.
Summary: This study reports clinical and virological findings of pregnant women infected with SARS-CoV-2 in Brazil. The study reveals various outcomes, such as spontaneous abortion, stillbirth, preterm births, and full-term birth. Genetic analysis shows mutations in viral genomes and associated proteins. These findings contribute to understanding the impact of SARS-CoV-2 infection on pregnant women and their fetuses.
MICROBES AND INFECTION
(2022)
Article
Virology
Svetoslav Nanev Slavov et al.
Summary: This study analyzed the genomic diversity of the SARS-CoV-2 alpha variant in the state of Sao Paulo, Brazil, and found multiple independent introductions of the variant. The molecular epidemiology of the alpha variant in Sao Paulo highlights the need for continued genomic surveillance.
Article
Microbiology
Bianca Monteiro Henriques-Santos et al.
Summary: Since December 2019, SARS-CoV-2 infections have posed a significant global public health threat. Despite increasing vaccination efforts and relaxed social distancing measures, the emergence of new variants continues to make the pandemic a persistent threat. This retrospective study analyzed samples from a cohort of industry workers in Rio de Janeiro State, using a mutation panel to track the circulation of different SARS-CoV-2 variants. The results showed that the Zeta variant had been circulating since October 2020, reaching a prevalence of 87% in February 2021, but its prevalence decreased due to the emergence of the Gamma variant.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Ana Valesca Fernandes Gilson Silva et al.
Summary: This study conducted epidemiological monitoring using diverse strategies to describe the initial stages of the COVID-19 pandemic in Betim City, Brazil. The results revealed the prevalence of the virus, risk factors for positivity, and multiple viral introductions.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Felipe Gomes Naveca et al.
Microbiology Spectrum
(2022)
Article
Microbiology
Priscila Lamb Wink et al.
Summary: The P.1 lineage of SARS-CoV-2, which is associated with increased transmissibility and/or immune evasion, has shown a dynamic evolution in Brazil. This study evaluated the circulating lineages in Southern Brazil and found that the P.1 lineage emerged earlier in Rio Grande do Sul state than previously reported in Amazonas state. The high genetic diversity among P.1 sequences suggests ongoing evolution and community spread of the virus.
MICROBIOLOGY SPECTRUM
(2022)
Article
Medicine, General & Internal
Ricardo Ariel Zimerman et al.
Summary: P.1 (Gamma) lineage, a variant of concern of SARS-CoV-2, was first identified in the State of Amazonas, Brazil, and has shown continuous evolution with rare mutations in spike and non-structural proteins. The lineage is associated with increased infectivity, higher mortality, and immune evasion, potentially impacting vaccine efficacy. The emergence of P.1 is mainly driven by strong evolutionary forces and the accumulation of favorable mutations.
FRONTIERS IN MEDICINE
(2022)
Letter
Public, Environmental & Occupational Health
Fabiana Caroline Zempulski Volpato et al.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2022)
Letter
Public, Environmental & Occupational Health
Priscila Lamb Wink et al.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2022)
Article
Virology
Gabriella S. Oliveira et al.
Summary: By actively monitoring COVID-19 patients and their close contacts, we identified the presence of the Mu variant circulating in Porto Velho-Rondonia, Brazil. This variant was found in individuals without recent travel history, highlighting the importance of genomic surveillance in detecting emerging variants in the community.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Virology
Alex Ranieri Jeronimo Lima et al.
Summary: In this study, two emerging sublineages of SARS-CoV-2 were identified in the state of Sao Paulo, Brazil. These sublineages may have a Brazilian origin and their impact on vaccination and public health policies is still unknown.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Genetics & Heredity
Zhiyuan Chen et al.
Summary: This study analyzed global SARS-CoV-2 genomic surveillance and genomic data, finding significant variations in surveillance and sequencing capabilities among different countries. It also identified heterogeneity in sequencing percentage, sequencing technologies, turnaround time, and completeness of released metadata across regions and income groups. Moreover, it revealed a lack of proactive sharing of sequences related to variant of concerns (VOCs) in public repositories by some countries. Urgent actions are required to enhance timely and full sharing of sequences, standardize metadata files, and support countries with limited sequencing and bioinformatics capacity.
Article
Virology
Juliana Schons Gularte et al.
Summary: The Delta variant has replaced the Gamma variant in Brazil and has spread widely within a short period of time, and it has a high mutation rate.
Article
Virology
Ueric Jose Borges de Souza et al.
Summary: This study analyzed the relative prevalence of SARS-CoV-2 lineages in the state of Tocantins, Brazil, and identified the viral dispersal routes of the two most abundant lineages. The results highlighted the importance of trade routes in the transportation of the virus from Southeast to Northern Brazil.
Article
Virology
Douglas Adamoski et al.
Summary: Screening efforts and genomic surveillance are crucial for evaluating the progress of the COVID-19 pandemic. A study in Curitiba, Brazil analyzed COVID-19 cases, conducted diagnosis and genotyping, and found that the Omicron variant quickly became dominant. Vaccination was associated with reduced mortality rates.
Article
Virology
Joice P. Silva et al.
Summary: A national epidemiological surveillance program was conducted in Brazil from April to October 2021 to monitor the dynamics and dissemination of COVID-19 VOCs. The study found that Delta VOC was first detected in June 2021 and replaced Gamma VOC within sixteen weeks. Furthermore, it was found that Delta VOC has a higher transmission rate than Gamma VOC and individuals infected with Delta VOC exhibit different symptom presentations.
Article
Medicine, General & Internal
Zoraida Fernandez et al.
Summary: This study investigated the presence of SARS-CoV-2 infection in placenta and fetal samples from an early pregnancy miscarriage in Midwest Brazil. The Gamma variant was detected in the placenta sample but not in the fetal samples. The findings emphasize the potential adverse perinatal outcomes associated with SARS-CoV-2 Gamma infection during pregnancy.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Sergio N. Kuriyama et al.
Summary: The Occupational Health Center in Rio de Janeiro, Brazil, provided molecular diagnosis and genomic sequences for companies and industries. From May to August 2021, they sequenced around 20% of the SARS-CoV-2 positive swabs from routinely tested workers and found the replacement of Gamma with Delta variant. They also identified B.1.139 and A.2.5 viral genomes in Brazil and improved the understanding of Delta VoC evolution.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Tiago Graf et al.
Summary: The COVID-19 epidemic in Brazil saw two major lineage replacements - P.2 and Gamma. Research suggests that P.2 emerged in July 2020 in Rio de Janeiro and Gamma emerged in November 2020 in Amazonas. Both states served as hubs for viral dissemination to other areas in Brazil. Additionally, the study found that Gamma was more transmissible than P.2 in Rio de Janeiro, with the median effective reproductive number varying based on geographic context.
Article
Public, Environmental & Occupational Health
Alexandre P. Zavascki et al.
Summary: A study in Brazil investigated the clinical course of COVID-19 caused by the SARS-CoV-2 gamma variant and non-variants of concern (VOCs). It found that patients infected with the gamma variant had higher rates of advanced respiratory support and mortality compared to non-gamma-infected patients.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Virology
Cristina Mendes de Oliveira et al.
Summary: In January 2022, a case of coinfection with SARS-CoV-2 BA.1 and BA.2 was identified in a patient in Brazil, suggesting that the actual number of SARS-CoV-2 coinfections may be largely underestimated.
ARCHIVES OF VIROLOGY
(2022)
Article
Microbiology
Juliana Schons Gularte et al.
Summary: Different approaches, such as cell culture-based methods and next-generation sequencing, have been used to improve our understanding of the causative agent of COVID-19. By isolating and sequencing samples collected from April to July 2020, the researchers identified the B.1.1.33 lineage and described new mutations. These findings contribute to our knowledge of the spread and evolution of the pandemic.
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2022)
Article
Virology
Hugo Jose Alves et al.
Summary: Since its first identification in Brazil, the Gamma variant has been associated with increased infection and transmission rates, leading to peaks of cases and deaths in Minas Gerais state. The study found Gamma to be the most common variant, but clusters of Zeta and Alpha variants were also observed. In addition, other rare variant lineages were identified. Genomic characterization estimated the introduction of Gamma in January 2021. The study emphasizes the importance of vaccination programs in preventing severe cases and deaths.
Article
Virology
Vincent Louis Viala et al.
Summary: Our study in Brazil found a high prevalence of the Alpha Variant of Concern in the population of Ilhabela island, which was distinct from the dominance of the Gamma VOC on the mainland. The study highlights the importance of specific programs for SARS-CoV-2 genomic surveillance in isolated populations.
Article
Virology
Paula L. C. Fonseca et al.
Summary: The emergence and spread of the Delta variant in the state of Minas Gerais, Brazil, was monitored through genotyping and genome sequencing. The Delta variant accounted for 70% of cases after 8 weeks and showed higher transmissibility compared to the Gamma variant. The dominance of the Delta variant did not result in an increase in cases and deaths, indicating that vaccination may have played a role in restraining the epidemic growth.
Article
Medicine, General & Internal
Camila Malta Romano et al.
Summary: The year of 2021 saw the emergence and spread of various SARS-CoV-2 lineages, causing a third wave of COVID-19 in multiple countries. In Brazil, the AY.99.2 and AY.101 lineages became the most prevalent, surpassing the Gamma variant. AY.99.2 likely appeared a few weeks after the entry of the B.1.617.2 variant in Brazil and rapidly spread to other countries.
FRONTIERS IN MEDICINE
(2022)
Article
Microbiology
Daniel Costa Queiroz et al.
Summary: This report presents the genomic surveillance results of SARS-CoV-2 in Belo Horizonte, Brazil, between March and June 2022. The BA.2 clade gradually replaced the BA.1 clade, and two XAG recombinants were found in the 22nd week. Diversification of the omicron variant appears to have contributed to the resurgence of cases in the region, similar to what has been observed in South Africa.
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2022)
Article
Virology
Mariana Soares da Silva et al.
Summary: This study aims to analyze and summarize information about the genetic characteristics, amino acid mutations, and epidemiological data of the SARS-CoV-2 Omicron variant, providing scientific findings to enrich our understanding of this variant.
Article
Virology
Francisca Andrea da Silva Oliveira et al.
Summary: This study analyzed the circulating lineages and genomic variations of the virus in the state of Ceará, Brazil. The most prevalent lineages were B.1.1.33 in 2020 and P.1 in 2021. A total of 202 single-nucleotide polymorphisms (SNPs) were identified among the 34 sequenced genomes, with 127 missense mutations, 74 synonymous mutations, and one nonsense mutation. Despite the limited sequencing data in 2020, these results provide insights into the genetic diversity of circulating lineages in Ceará.
Article
Virology
Josilene R. Pinheiro et al.
Summary: This study investigated the epidemiological dynamics of COVID-19 in a Brazilian population of nearly 17,000 patients over a 15-month period. The study found that COVID-19 cases and deaths fluctuated over time, with men and individuals over the age of 60 being the most affected by deaths. Furthermore, individuals between the ages of 30 and 44 were the most affected by COVID-19 cases. The study also revealed that viral loads in the nasopharynx were higher during the early symptomatic period. Additionally, the study discovered a significant increase in deaths during the second half of the study period, as early pandemic SARS-CoV-2 lineages were replaced by the variant of concern (VOC) P.1 (Gamma).
Article
Public, Environmental & Occupational Health
Mariana Soares da Silva et al.
Summary: A potentially new variant derived from the B.1.1.28 lineage was detected in travelers crossing the Brazil-Argentina border, representing an important peak of B.1.1.28 in RS state with a decreased frequency of the Gamma variant during the same period.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2022)
Article
Infectious Diseases
Francisco P. Freire-Neto et al.
Summary: This study investigated an outbreak of SARS-CoV-2 reinfections in Rio Grande do Norte state, Brazil in mid-January 2022. The findings suggest that the reinfections were primarily caused by the Omicron variant and occurred among individuals who were fully vaccinated against SARS-CoV-2.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Microbiology
Marta Giovanetti et al.
Summary: The COVID-19 pandemic in Brazil is assessed using phylogenetic and phylogeographic analysis. Multiple viral lineages were found to be circulating in Brazil with links to importations from Europe. Large local transmission clusters were detected within the country, and variants of concern and variants under monitoring emerged and spread both within and outside Brazil. Genomic surveillance in Brazil enabled real-time assessment of the spread of emerging SARS-CoV-2 variants.
NATURE MICROBIOLOGY
(2022)
Article
Genetics & Heredity
Alessandra Pavan Lamarca et al.
Summary: During the first semester of 2021, Brazil experienced a severe wave of COVID-19 with the Gamma variant, followed by the Delta variant. Through genomic sequencing analysis, it was found that the Delta variant replaced the Gamma variant and spread throughout the state of Rio de Janeiro. The spread of the Delta variant initially occurred in the city of Rio de Janeiro and then extended to other cities. The Delta variant has higher transmissibility but lower lethality, which could be attributed to the high vaccination rates in the state.
MICROBIAL GENOMICS
(2022)
Article
Microbiology
Ighor Arantes et al.
Summary: Amid the continuously changing epidemic profile of SARS-CoV-2, this study provides a detailed analysis of the emergence of the Delta lineage in different regions of Brazil, including its multiple introductions and prevalent sublineages. Some sublineages are described in terms of their emergence, genomic composition, and geographic distribution for the first time. Notably, the study focuses on the emergence of Delta outside of the southern and southeastern regions of Brazil, which have been the subject of most SARS-CoV-2 studies in the country. Overall, this research contributes to a better understanding of the evolutionary process of the Delta lineage and its association with a resurgence of the pandemic in Brazil.
MICROBIOLOGY SPECTRUM
(2022)
Article
Medicine, General & Internal
Joao Silveira Moledo Gesto et al.
Summary: The global spread of SARS-CoV-2 has caused significant pressure on human societies, and early diagnosis and isolation of positive individuals can reduce transmission rates. Through monitoring companies in Brazil, the introduction of the Omicron variant was linked to a rise in infection rates. Genomic analysis revealed possible migration routes and no strong evidence of transmission chains. These findings highlight the importance of a comprehensive strategy to limit the spread of the virus.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Thais de Souza Silva et al.
Summary: Recombination events in the Coronaviridae family can lead to the emergence of new strains with increased fitness. This study characterized a new SARS-CoV-2 recombinant identified in Brazil and showed its evolutionary history through phylogenetic analysis.
FRONTIERS IN MEDICINE
(2022)
Review
Medicine, General & Internal
Eva Draborg et al.
Summary: This systematic review reveals a low rate and significant variability in the use of systematic reviews to place new results in the context of existing studies within the field of health research.
SYSTEMATIC REVIEWS
(2022)
Article
Multidisciplinary Sciences
Tiago Souza Salles et al.
Summary: This study presents a feasible protocol for complete nucleotide sequencing of the S gene of SARS-CoV-2 using the Sanger technique. This method is important for urgent surveillance and effective monitoring of the virus's spread and evolution.
Article
Medicine, Research & Experimental
Cecilia Artico Banho et al.
Summary: The emergence of the Brazilian Gamma variant has impacted the epidemiological profile of COVID-19 cases, with higher transmissibility and immune evasion ability. The study showed that the Gamma variant rapidly increased in prevalence two months after its first detection in Sao Paulo, Brazil, and displaced seven circulating variants. Additionally, it was associated with increased mortality risk and severity of COVID-19 cases in younger age groups.
COMMUNICATIONS MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Lucyene Miguita et al.
Summary: A longitudinal study on dental clinics at a university showed that dental practice can be safely conducted with appropriate control measures and biosafety protocols, resulting in low risk of SARS-CoV-2 cross-infection.
FRONTIERS IN ORAL HEALTH
(2022)
Letter
Immunology
Juliana F. da Silva et al.
Summary: Investigation of a cluster of coronavirus disease cases in Parintins, Brazil, after the emergence of the Gamma variant did not find high rates of reinfection, indicating that previously infected persons may not be at significant risk of becoming reinfected.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Microbiology
Juliana Schons Gularte et al.
Summary: This study described two cases of reinfection caused by non-VOC strains of SARS-CoV-2 in southern Brazil, indicating that patients may be reinfected even by closely related virus lineages. The interval between the two positive RT-qPCR tests for the two patients was 45 and 61 days, respectively.
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2021)
Article
Infectious Diseases
Carlos Henrique Camargo et al.
Summary: This study reports two cases of Coronavirus Disease 2019 infection in the same healthcare professional in Brazil. Genomic analysis identified that the first infection was caused by lineage B.1.1.33 while reinfection was caused by lineage B.1.1.44 with an additional V1176F mutation in the S protein.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2021)
Article
Biotechnology & Applied Microbiology
Erick Gustavo Dorlass et al.
Summary: The rapid detection of genetic variants of SARS-CoV-2 plays a crucial role in impacting virus transmission, disease severity, vaccine response, and patient management. Sanger sequencing has been effective in quickly detecting the introduction and spread of different SARS-CoV-2 variants, aiding in timely response measures.
Article
Infectious Diseases
Ana Paula Muterle Varela et al.
Summary: This study analyzed the genomic diversity of SARS-CoV-2 in Rio Grande do Sul, Brazil, across different epidemic peaks. The research identified transmission patterns, mutation combinations, and high genetic diversity among SARS-CoV-2 lineages, highlighting the importance of genomic surveillance in guiding health authorities' decisions to control COVID-19 in Brazil.
INFECTION GENETICS AND EVOLUTION
(2021)
Article
Infectious Diseases
Meriane Demoliner et al.
Summary: The highest wave of SARS-CoV-2 epidemic in Rio Grande do Sul, Southern Brazil, since the beginning of the pandemic was predominantly caused by the Gamma lineage, with the emergence of a new S:D614A mutation. Understanding immune protection and vigilance towards variants is essential for better management of the health crisis caused by SARS-CoV-2.
INFECTION GENETICS AND EVOLUTION
(2021)
Letter
Public, Environmental & Occupational Health
Ighor Gomes Arantes et al.
Summary: The Lambda variant of SARS-CoV-2 has been classified as a variant of concern by the World Health Organization due to its increased infectivity and immune escape qualities. Evidence suggests that this variant has been introduced multiple times in Brazil, posing a growing epidemiological threat in South America.
JOURNAL OF TRAVEL MEDICINE
(2021)
Article
Virology
Alessandra P. Lamarca et al.
JOURNAL OF VIROLOGY
(2021)
Review
Multidisciplinary Sciences
Juan Li et al.
Summary: Since the emergence of COVID-19 in Wuhan in 2019, the world has faced a devastating pandemic with millions of cases and fatalities. This article provides insights into the spread and genetic variations of the SARS-CoV-2 virus, emphasizes the importance of genomic surveillance, and highlights the international transmission of major variants identified late in 2020.
Article
Infectious Diseases
Leticia Adrielle dos Santos et al.
Summary: This study presents 33 cases of recurrent COVID-19, with most cases being healthcare workers and blood type A. The average time to recurrence was 50.5 days, and recurrent patients had significantly lower SARS-CoV-2 antibodies in their system.
JOURNAL OF INFECTION
(2021)
Editorial Material
Public, Environmental & Occupational Health
Cliomar Alves dos Santos et al.
JOURNAL OF TRAVEL MEDICINE
(2021)
Letter
Virology
Carolina M. Voloch et al.
JOURNAL OF VIROLOGY
(2021)
Article
Engineering, Environmental
Tatiana Prado et al.
Summary: The study monitored SARS-CoV-2 RNA in wastewater in Niteroi city, Brazil, finding a positive rate ranging from 42% to 100% throughout the study period, with high viral concentrations.
Article
Multidisciplinary Sciences
Luan Felipo Botelho-Souza et al.
Summary: The study identified 22 mutations in strains isolated in the Western Amazon, Brazil, some of which may affect the transmissibility and replication fidelity of the virus. At least two introductions of the virus were detected, possibly originating from Europe and Argentina, before spreading to Rondonia in Brazil.
SCIENTIFIC REPORTS
(2021)
Article
Virology
Mauro M. Oliveira et al.
Summary: The genomic surveillance of SARS-CoV-2 lineages in Parana, southern Brazil, from March 2020 to April 2021 revealed the dominance of the Gamma strain, as well as high frequencies of the Gamma-like-II lineage and the S:E661D mutation. Further efforts in epidemiological and genomic surveillance are needed to understand the implications of these novel mutations identified in the VOC Gamma in Parana.
Article
Microbiology
Paola Cristina Resende et al.
Summary: This study explores the origin and dissemination of the SARS-CoV-2 Brazilian lineage B.1.1.33, indicating that it may have emerged in Brazil in early February 2020 and subsequently evolved into a major circulating lineage. The lineage spread to various Brazilian regions and countries worldwide by March 2020, before air travel restrictions were implemented in Brazil. Public health interventions were partially effective in controlling the spread of lineage B.1.1.33, reducing its effective reproductive number by about 66% in Rio de Janeiro during March 2020, but failing to bring it below one. Continuous genomic surveillance of this lineage could provide valuable information on epidemic dynamics and the effectiveness of public health interventions in certain Brazilian states.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Virology
William M. de Souza et al.
Summary: The study found that the B.1.1.7 VOC variant can infect vaccinated individuals, especially those who have received only one dose of the vaccine. Although the vaccines can reduce the risk of severe disease and death caused by this variant, some individuals still get infected.
Article
Virology
Ronaldo da Silva Francisco Junior et al.
Summary: The genomic epidemiology analysis of the SARS-CoV-2 pandemic in Rio de Janeiro, Brazil revealed three phases driven by lineage replacement. Viral supercarriers accounted for the majority of circulating virus among symptomatic individuals, and two new variants (P.5 and P.1.2) were identified. These findings offer important lessons for public health management and understanding virus dispersion mechanisms.
Article
Virology
Juliana D. Siqueira et al.
Summary: The study examined SARS-CoV-2 genomic sequences and intrahost viral population diversity in cancer patients and healthcare workers with COVID-19. Cancer patients exhibited higher intrahost viral genetic diversity compared to healthcare workers, but this was not associated with disease severity or other factors.
Article
Infectious Diseases
Alessandra P. Lamarca et al.
Summary: The sharp increase of COVID-19 cases in late 2020 has made Brazil the new epicenter of the ongoing SARS-CoV-2 pandemic. The study identified the widespread dispersal of P.1 and P.2 lineages across Brazil, with P.2 being the predominant lineage in most states. The presence of new lineages descending from B.1.1.33, including those carrying the E484K mutation, highlights the importance of continuous sequencing to monitor vaccine effectiveness and identify novel variants of interest.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Immunology
Vanessa C. Nicolete et al.
Summary: A study in Amazonian Brazil found that individuals with prior dengue virus infection had a higher risk of clinically apparent COVID-19 after contracting SARS-CoV-2, with those over 60 years old being more likely to have symptomatic COVID-19. Local SARS-CoV-2 isolates belonged to the B.1.1.33 lineage.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Andreza Francisco Martins et al.
Summary: A study in Brazil found that the emergence of the SARS-CoV-2 P.1 lineage coincided with a surge in hospitalisations. Severe COVID-19 cases in the South region rose significantly in February 2021, raising concerns about a possible association between the P.1 lineage and rapid increases in cases.
Article
Virology
Filipe Romero Rebello Moreira et al.
Summary: The research investigated the spread of the Gamma variant of the coronavirus in Rio de Janeiro, Brazil, between December 2020 and May 2021, and found that this variant spread rapidly, leading to the third local epidemic wave. Molecular clock analysis and Bayesian phylogeographic reconstruction showed that the variant began circulating locally in early 2021 and rapidly reached a frequency of over 70% in just 7 weeks. Additionally, comparative analysis of RT-qPCR cycle threshold (Ct) values indicated that the Gamma variant induces higher viral loads.
Article
Virology
Tiago Graf et al.
Summary: The study describes a new SARS-CoV-2 P.1 sub-lineage circulating in Brazil, denoted as Gamma-like-II, which shares several lineage-defining mutations with the VOC Gamma. This suggests a complex interplay between the emergence of mutations of concern and viral spread in Brazil.
Article
Medicine, General & Internal
Marielton dos Passos Cunha et al.
Summary: A study showed that some individuals mildly affected by SARS-CoV-2 infection exhibited atypical durations of viral shedding, with one HIV-positive patient shedding SARS-CoV-2 RNA and sgRNA for 232 and 224 days respectively after onset. These results suggest that some infected patients might shed potentially infectious SARS-CoV-2 virus for longer periods of time.
FRONTIERS IN MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Cintia Bittar et al.
Summary: The emergence of a new SARS-CoV-2 lineage named P.4 in Porto Ferreira, Sao Paulo, Brazil has been increasing in frequency since its first detection in March 2021, becoming the second most prevalent lineage after P.1. It is circulating in 30 cities in the state of Sao Paulo, and has also been detected in samples from the states of Sergipe and Rio de Janeiro. Further studies are needed to determine if P.4 poses a new threat.
FRONTIERS IN PUBLIC HEALTH
(2021)
Letter
Public, Environmental & Occupational Health
Cliomar Alves dos Santos et al.
Summary: Since March 2020, 11 lineages of severe acute respiratory syndrome coronavirus 2 have been identified in Sergipe state, Northeast Brazil. During the first 6 months of the COVID-19 outbreak, there was a higher frequency of B.1 and B.1.1.33 lineages. During the second wave, there was an increased frequency of the new Brazilian variant of concern, P.1.
JOURNAL OF TRAVEL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Marcia C. Castro et al.
Summary: The study found that COVID-19 in Brazil is spreading rapidly across municipalities with distinct spatial and temporal patterns of clustering, trajectories, and speed. Analysis shows that inadequate policy measures have led to high transmission and mortality burdens. The current surge in cases and deaths, along with the circulation of concerning variants, highlights the need for government to strengthen prevention and control measures.
Article
Multidisciplinary Sciences
Nuno R. Faria et al.
Summary: A new variant of concern, P.1, with 17 mutations including three spike protein mutations associated with increased binding to human ACE2 receptors, emerged in Manaus, Brazil between November 2020 and January 2021. Molecular analysis suggests P.1 may be 1.7- to 2.4-fold more transmissible and that previous infection may provide 54 to 79% protection against P.1 infection compared to other lineages. Enhanced global genomic surveillance of such variants is crucial for pandemic response.
Article
Virology
Ronaldo da Silva Francisco Jr et al.
Summary: The emergence of novel SARS-CoV-2 lineages, including B.1.1.28 (E484K), in Rio Grande do Sul, Brazil has raised global concerns. Co-infection events and the identification of a new sample cluster named VUI-NP13L underscore the importance of strict and effective social distancing measures to combat the spread of potentially more hazardous SARS-CoV-2 strains.
Article
Public, Environmental & Occupational Health
Karoline Rodrigues Campos et al.
Summary: COVID-19 vaccination began in Sao Paulo, Brazil in January 2021, targeting healthcare workers and the elderly first. Studies have shown efficacy of the vaccines in preventing severe cases and deaths. Data from the Instituto Adolfo Lutz in Sao Paulo revealed that most severe cases were among CoronaVac vaccinated individuals with the gamma variant.
REVISTA PANAMERICANA DE SALUD PUBLICA-PAN AMERICAN JOURNAL OF PUBLIC HEALTH
(2021)
Article
Virology
Paola Cristina Resende et al.
Summary: This study reports the identification of a new SARS-CoV-2 VOI within lineage B.1.1.33 in Brazil, which carries the S:E484K mutation. This VOI, designated as lineage N.9, emerged in August 2020 and has spread across different regions in Brazil.
Article
Multidisciplinary Sciences
Talita Emile Ribeiro Adelino et al.
Summary: Brazil faced a significant dengue virus epidemic in 2019, and through the use of Oxford Nanopore sequencing, researchers successfully monitored and generated 227 novel genome sequences of DENV1-2 from 85 municipalities. The study revealed complex transmission patterns of DENV1-2, with lineage co-circulation and replacement, and estimated effective reproduction numbers and patterns of seasonality for two lineages within the DENV2 BR-4 clade. The surveillance outputs and training initiatives presented here demonstrate the potential of real-time portable sequencing for genomic surveillance of emerging viruses.
NATURE COMMUNICATIONS
(2021)
Review
Medicine, General & Internal
Matthew J. Page et al.
Summary: The PRISMA statement was designed to help systematic reviewers transparently report the purpose, methods, and findings of their reviews. The updated PRISMA 2020 statement includes new reporting guidance, a 27-item checklist, an abstract checklist, and revised flow diagrams for reviews.
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Article
Biotechnology & Applied Microbiology
Vinicius Bonetti Franceschi et al.
Summary: This study tracked the molecular evolution and spread of SARS-CoV-2 in Esteio, Southern Brazil, highlighting mutations from May to October 2020, including common mutations in spike glycoprotein and an emergent mutation in spike Receptor Binding Domain. The study also found epidemiologically-related clusters, demonstrating multiple introductions of prevalent Brazilian lineages and their spread to other regions. The correlation of clinical, epidemiological, and genomic information is crucial for understanding viral evolution and informing policy making strategies to combat COVID-19.
Article
Infectious Diseases
Svetoslav Nanev Slavov et al.
Summary: This study examined the SARS-CoV-2 genotypes in Ribeira Preto city through genomic surveillance data. Results showed that most strains obtained in the initial period of the pandemic in Ribeira Preto belonged to the B1.1.33 lineage, while the second wave strains were exclusively composed of the Brazilian variant of concern (VOC) P.1 lineage. These phylogenetic results suggest successive lineage substitutions by the P.1 VOC in this Brazilian region.
INFECTION GENETICS AND EVOLUTION
(2021)
Letter
Infectious Diseases
Vagner Fonseca et al.
JOURNAL OF INFECTION
(2021)
Article
Virology
Svetoslav N. Slavov et al.
Summary: Sao Paulo State in Brazil is facing a second wave of COVID-19, with a network established to monitor the spread of SARS-CoV-2 variants. Analysis of 210 genomes revealed multiple circulating lineages, with the P.1 lineage predominant and the first detection of the South African B.1.351 (beta) variant in Brazil. Vigilant monitoring is crucial for pandemic control and vaccination strategies.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Felipe Gomes Naveca et al.
Summary: Analysis of circulating SARS-CoV-2 viruses during the first and second waves of COVID-19 in Amazonas, Brazil, shows successive lineage replacements led to predominance of the variant of concern P.1 and are associated with variable levels of social distancing.
Article
Biochemistry & Molecular Biology
Marcia C. Castro et al.
Summary: Brazil has been heavily impacted by COVID-19, with a significant increase in deaths in 2020 and 2021, leading to a decline in life expectancy and mortality levels not seen since 20 years ago.
Article
Environmental Sciences
Gislaine Fongaro et al.
Summary: SARS-CoV-2 RNA was detected in human sewage samples from Florianopolis, Brazil from November 2019 to March 2020, earlier than the first reported case in the Americas. This suggests that the virus may have been circulating undetected in the community.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Virology
Cassia F. Estofolete et al.
Summary: The development of effective vaccines against COVID-19 has helped in reducing the transmission of the virus, but the emergence of variants poses challenges. Breakthrough infections after vaccination highlight the importance of continued vigilance and efforts to prevent and diagnose infections among vaccinated individuals.
Editorial Material
Virology
Filipe R. R. Moreira et al.
Article
Microbiology
Daiana Mir et al.
Summary: Despite successfully containing the COVID-19 epidemic, Uruguay faced challenges due to intense human mobility with Brazil. Genetic analyses indicated multiple introductions of SARS-CoV-2 from Brazil to Uruguay, leading to local outbreaks in border areas. Enhanced bi-national surveillance is essential for controlling virus spread in such highly permeable border regions.
FRONTIERS IN MICROBIOLOGY
(2021)
Editorial Material
Microbiology
Frank Konings et al.
Summary: A group convened and led by the Virus Evolution Working Group of the World Health Organization has announced a naming scheme to enable clear communication about SARS-CoV-2 variants of interest and concern.
NATURE MICROBIOLOGY
(2021)
Article
Virology
Aine O'Toole et al.
Summary: The global virus genomics community has responded unprecedentedly to the SARS-CoV-2 pandemic, leading to significant advances in 'real-time' generation and sharing of genomic data. The development of new analytical methods, such as pangolin, has been necessary to handle the rapid growth in virus genome data production. Pangolin has processed nearly two million virus genomes, aiding in SARS-CoV-2 genomic epidemiology and providing researchers with valuable information about the pandemic's transmission lineages.
Article
Virology
Paola Cristina Resende et al.
Summary: Mutations in both the receptor-binding domain (RBD) and the amino-terminal domain (NTD) of the SARS-CoV-2 Spike glycoprotein can alter its antigenicity, with Brazilian lineages showing convergent deletions and insertions in the NTD region, potentially impacting antibody neutralization.
Article
Immunology
Douglas Adamoski et al.
Summary: This study conducted a large-scale screening campaign for SARS-CoV-2 using two PCR-based approaches and variant genotyping to ensure a safer environment for employees of Federal University in Curitiba, Brazil. The rapid spread of the Gamma variant of concern was observed, which replaced other variants within less than 3 months.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Ana Lucia Frugis Yu et al.
Summary: Between February 26, 2020 and March 11, 2021, Brazil experienced a significant COVID-19 pandemic with a total of 11,439,558 cases and 277,102 deaths, with a particularly high number of cases in Sao Paulo State. The emergence of new variants of SARS-CoV-2 and cases of COVID-19 reinfections have raised concerns in Brazil.
REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO
(2021)
Article
Parasitology
Luis Fernando Lopez Tort et al.
Summary: The first detection of the N.9 variant in Rio de Janeiro State has been described, with four independent introductions of the N.9 lineage in October and December 2020, January and March 2021. The N.9 dissemination in Rio de Janeiro may have been limited by the emergence of other variants, such as the P.2 VOI Zeta.
MEMORIAS DO INSTITUTO OSWALDO CRUZ
(2021)
Article
Infectious Diseases
Mariana Soares da Silva et al.
Summary: The article describes an early case of P.1 primary infection in Southern Brazil in late November 2020, followed by a reinfection with P.2 variant in March 2021. Genomic analysis confirmed significant genetic differences between the two infections, indicating the spread and prominence of the P.1 variant in the region.
REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO
(2021)
Article
Immunology
Fernando Hayashi Sant'Anna et al.
Summary: This study analyzed 340 whole genomes of SARS-CoV-2 sampled between April and November 2020 in 33 cities of Rio Grande do Sul, South Brazil. Two novel emergent lineages and five major lineages were identified, emphasizing the importance of constant genomic surveillance.
EMERGING MICROBES & INFECTIONS
(2021)
Letter
Immunology
Mariene R. Amorim et al.
Summary: This study documented 4 cases of severe acute respiratory syndrome coronavirus 2 reinfection among healthcare workers in Campinas Brazil, with non-variant of cancern strains. Infectious particles were isolated from nasopharyngeal secretions during both infection episodes. Improved and continuous protection measures are necessary to mitigate the risk for reinfection among healthcare workers.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Immunology
Paola Cristina Resende et al.
Summary: A 37-year-old healthcare worker in northeastern Brazil experienced two clinical episodes of COVID-19 caused by the B.1.1.33 and emerging P.2 lineages. The findings not only suggest a reinfection case but also the geographic dissemination of the emerging Brazil clade P.2.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Immunology
Natalia Fintelman-Rodrigues et al.
Summary: This study found that some patients with mild COVID-19 may have controlled SARS-CoV-2 replication without developing detectable humoral immunity, leading to a higher likelihood of reinfection. These patients showed higher viral loads and clinical symptoms in the second infection.
EMERGING INFECTIOUS DISEASES
(2021)
Letter
Immunology
Carolina Kymie Vasques Nonaka et al.
Summary: The case of reinfection from distinct virus lineages in Brazil with the E484K mutation raises concerns about the duration of protective immune responses against SARS-CoV-2, especially with the variant associated with escape from neutralizing antibodies. This highlights potential challenges for virus control measures.
EMERGING INFECTIOUS DISEASES
(2021)
Letter
Immunology
Ingra Morales Claro et al.
Summary: In December 2020, the B.1.1.7 lineage of SARS-CoV-2 was detected in Sao Paulo, Brazil, with two distinct introductions identified through rapid genomic sequencing. There may be more infections with this lineage in Brazil than officially reported.
EMERGING INFECTIOUS DISEASES
(2021)
Letter
Infectious Diseases
Ensheng Dong et al.
LANCET INFECTIOUS DISEASES
(2020)
Article
Biochemistry & Molecular Biology
Bui Quang Minh et al.
MOLECULAR BIOLOGY AND EVOLUTION
(2020)
Article
Medicine, General & Internal
Na Zhu et al.
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Article
Microbiology
Andrew Rambaut et al.
NATURE MICROBIOLOGY
(2020)
Article
Multidisciplinary Sciences
Darlan S. Candido et al.
Article
Virology
Marcelo Henrique Santos Paiva et al.
Article
Parasitology
Valdinete Alves do Nascimento et al.
MEMORIAS DO INSTITUTO OSWALDO CRUZ
(2020)
Article
Parasitology
Danielle Bastos Araujo et al.
MEMORIAS DO INSTITUTO OSWALDO CRUZ
(2020)
Article
Immunology
Joilson Xavier et al.
EMERGING MICROBES & INFECTIONS
(2020)
Article
Infectious Diseases
Felipe Gomes Naveca et al.
PLOS NEGLECTED TROPICAL DISEASES
(2019)
Article
Biochemical Research Methods
James Hadfield et al.
Article
Multidisciplinary Sciences
Nuno Rodrigues Faria et al.
Review
Medicine, General & Internal
Alison Booth et al.
SYSTEMATIC REVIEWS
(2012)
Article
Health Care Sciences & Services
Valentina Gallo et al.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2011)
Article
Computer Science, Interdisciplinary Applications
Nees Jan van Eck et al.
Article
Health Care Sciences & Services
Erik von Elm et al.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2008)
