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Article
Medicine, General & Internal
Krystyna Dobrowolska et al.
Summary: The study aimed to compare the baseline characteristics and outcomes of patients hospitalized during the Delta and Omicron predominance in Poland. The results showed that during the Delta wave, patients were younger and had fewer comorbidities compared to the Omicron surge. Omicron-infected patients presented less often in an unstable symptomatic state with low oxygen saturation on admission. Antiviral drugs were more frequently used during the Omicron wave, and the risk of mechanical ventilation and death was lower for Omicron-infected patients.
POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ
(2023)
Article
Pharmacology & Pharmacy
Laura Vangeel et al.
Summary: Remdesivir and its parent nucleoside, molnupiravir and its parent nucleoside, and the viral protease inhibitor nirmatrelvir have equipotent antiviral activity against the ancestral SARS-CoV2 strain and the variants of concern including Omicron.
ANTIVIRAL RESEARCH
(2022)
Letter
Infectious Diseases
Giuseppe Lippi et al.
JOURNAL OF INFECTION
(2022)
Article
Virology
Shailendra K. Saxena et al.
Summary: Omicron is the latest variant of concern of SARS-CoV-2, with more mutations compared to the previous Delta variant. Fifteen of these mutations are located in the receptor-binding domain of the spike glycoprotein, which may affect transmissibility, infectivity, antibody neutralization, and vaccine efficacy. The study provides insights into the mutational hotspots of Omicron and its global impact on transmission, testing, and immunity.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Multidisciplinary Sciences
Bo Meng et al.
Summary: The Omicron variant of SARS-CoV-2 has a higher affinity for ACE2 and can evade neutralizing antibodies more effectively compared to the Delta variant. A third dose of mRNA vaccine can provide enhanced protection. Omicron has lower replication in lung and gut cells and less efficiently cleaves its spike protein compared to Delta.
Article
Multidisciplinary Sciences
Rigel Suzuki et al.
Summary: The Omicron variant of SARS-CoV-2 has spread rapidly in several countries and has shown lower fusogenicity and attenuated pathogenicity compared to the Delta variant.
Article
Multidisciplinary Sciences
Yunlong Cao et al.
Summary: The Omicron variant of SARS-CoV-2 contains 15 mutations in the receptor-binding domain, leading to evasion of over 85% of tested neutralizing antibodies. Different epitope groups of neutralizing antibodies are affected to varying degrees by single mutations of Omicron. Antibodies targeting the conserved region of sarbecovirus remain most effective against Omicron.
Article
Multidisciplinary Sciences
Suresh V. Kuchipudi et al.
Summary: White-tailed deer, particularly in Iowa, have been found to be susceptible to SARS-CoV-2 infection and show evidence of human-to-deer transmission. This discovery highlights the need for a One Health approach to better understand the ecology, molecular evolution, and dissemination of the virus.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Public, Environmental & Occupational Health
A. Danielle Iuliano et al.
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2022)
Article
Public, Environmental & Occupational Health
Kristin J. Marks et al.
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2022)
Article
Public, Environmental & Occupational Health
Matthew E Modes et al.
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2022)
Article
Medicine, General & Internal
Robert Flisiak et al.
Summary: Long-term analysis of demographic and clinical characteristics of COVID-19 patients provides valuable insights into the clinical course of the disease and helps understand changes in infection symptoms and outcomes over time. This study highlights the importance of considering gender differences and SARS-CoV-2 variants in the analysis of COVID-19 patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Infectious Diseases
F. Abdullah et al.
Summary: This study analyzed the clinical data of COVID-19 patients admitted to a hospital in Tshwane during the Omicron wave, and found that the severity of the disease was decreased compared to previous waves, with lower death rates and ICU admissions.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Letter
Microbiology
Andrew M. Laitman et al.
JOURNAL OF CLINICAL MICROBIOLOGY
(2022)
Article
Infectious Diseases
Katherine A. Twohig et al.
Summary: A study in England found that patients with COVID-19 infected with the delta variant were more likely to be admitted to hospital or attend emergency care compared to those infected with the alpha variant. This suggests that outbreaks of the delta variant in unvaccinated populations may pose a greater burden on healthcare services.
LANCET INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Tommy Nyberg et al.
Summary: The Omicron variant shows lower severity compared to Delta, especially in terms of hospital admission and death, with significant variations by age. Unvaccinated cases experience a larger reduction in intrinsic severity, while vaccinated cases experience reduced vaccine effectiveness. Booster vaccination with mRNA vaccines provides over 70% protection against hospitalization and death in breakthrough Omicron infections.
Article
Infectious Diseases
Peter Bager et al.
Summary: This study aimed to estimate the risk of hospitalization after infection with the SARS-CoV-2 omicron variant compared with the delta variant in Denmark. The results showed that vaccination was associated with a lower risk of hospitalization, and Omicron infection was associated with a lower risk of hospitalization compared to Delta infection.
LANCET INFECTIOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Olha Puhach et al.
Summary: The infectious viral load of SARS-CoV-2 Omicron BA.1 is lower than that of Delta in breakthrough infections of vaccinated individuals. Vaccines may lower transmission risk and have a public health benefit.
Article
Medicine, General & Internal
Adam S. Lauring et al.
Summary: mRNA vaccines were highly effective in preventing covid-19 associated hospital admissions related to the alpha, delta, and omicron variants. Three vaccine doses were required for protection against omicron, while two doses provided protection against delta and alpha variants. Omicron variant showed lower disease severity compared to delta variant but still resulted in morbidity and mortality. Vaccinated patients had lower disease severity than unvaccinated patients for all the variants.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Article
Public, Environmental & Occupational Health
Christopher A. Taylor et al.
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2022)
Article
Environmental Sciences
Piotr Rzymski et al.
Summary: Air pollution, especially the increase in benzo(a)pyrene (B(a)P) levels, has a significant impact on the clinical manifestation of COVID-19 in pediatric patients.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Piotr Rzymski et al.
Summary: This study investigates the relationship between symptomatology, clinical course, and inflammation markers of adult patients with COVID-19 and air pollution levels. The results indicate that exposure to elevated levels of PM2.5 and B(a)P is associated with early respiratory symptoms and hyperinflammatory state, as well as increased odds of oxygen therapy and death.
ENVIRONMENTAL POLLUTION
(2022)
Article
Infectious Diseases
Shivang Bhakta et al.
Summary: This study compared the characteristics of hospitalized patients between a Delta variant wave and a pre-Delta variant wave using clinical data. The findings showed that patients in the Delta variant wave were younger, had fewer comorbidities, required more intensive care, and showed higher levels of inflammatory markers.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Virology
Sonoka Yuasa et al.
Summary: The Omicron variant of COVID-19 has spread rapidly worldwide, surpassing the speed of the Delta variant. However, this increased transmissibility is not due to higher viral loads. The study suggests that factors such as increased affinity to cell receptors or immune escape may contribute to the enhanced infectivity of the Omicron variant.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Virology
Nina Van Goethem et al.
Summary: This retrospective study compared the risk of severe COVID-19, ICU admission, and in-hospital mortality between patients infected with the Omicron and Delta variants. The results showed a significantly lower risk of severe COVID-19 and ICU admission in patients infected with the Omicron variant, while there was no significant difference in in-hospital mortality according to the SARS-CoV-2 variant.
Article
Pediatrics
Jessica Taytard et al.
Summary: This study compared the symptoms, explorations, treatment, and evolution of hospitalized children with COVID-19 during the Delta and Omicron waves. Children hospitalized during the Omicron wave had more severe symptoms, including higher and poorly tolerated temperatures, and increased digestive symptoms compared to the Delta variant.
FRONTIERS IN PEDIATRICS
(2022)
Article
Pharmacology & Pharmacy
Robert Flisiak et al.
Summary: This study assessed the effectiveness of molnupiravir in hospitalized COVID-19 patients during the Omicron variant dominance, finding a significant reduction in mortality with MOL treatment, particularly in patients over 80 years of age.
PHARMACOLOGICAL REPORTS
(2022)
Review
Virology
Haifa Khemiri et al.
Summary: This study found that the incidence of SARS-CoV-2 infection was underestimated in infants, with most infected children presenting with asymptomatic or mild symptoms. The prevalence of COVID-19 varied by country, with the highest reported in the United States (22.5%). With the emergence of the B.1.617.2 Delta and B.1.1.529 Omicron variants, these variants appear to affect a large proportion of the younger population with similar clinical manifestations to adults and significant hospitalization rates.
Letter
Biochemistry & Molecular Biology
Leyun Wu et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Infectious Diseases
Van-Thuan Hoang et al.
Summary: This study compared the demographics, clinical characteristics, and severity of patients infected with different SARS-CoV-2 variants during various phases of the COVID-19 epidemic. Results showed that there were no major differences in age, gender, prevalence of chronic diseases, and clinical symptoms between variants in different phases, but certain variants were associated with more severe outcomes. Infections during the second phase had a higher death rate compared to the first and third phases.
INFECTION GENETICS AND EVOLUTION
(2021)
Article
Infectious Diseases
Adam Nagy et al.
Summary: The study found a correlation between protein-level mutations in the SARS-CoV-2 virus and clinical outcomes, with some mutations associated with severe disease.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Article
Virology
Mitchell Palmer et al.
Summary: White-tailed deer are highly susceptible to infection by SARS-CoV-2, shedding infectious virus and transmitting it to other deer upon intranasal inoculation, providing important insights into the potential animal hosts of the virus.
JOURNAL OF VIROLOGY
(2021)
Review
Environmental Sciences
Dariusz Halabowski et al.
Summary: The COVID-19 pandemic has caused significant burdens to healthcare systems, economies, and public fears, prompting the need for actions to minimize future viral pandemics. The importance of viral surveillance systems, research on animal hosts, stricter regulations on wildlife trade, and changes to hunting activities are emphasized in reducing such risks. Additionally, modifications to meat production, including introducing cultured meat, can enhance food security and mitigate environmental impacts.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Cell Biology
Markus Hoffmann et al.
Summary: Transmission of SARS-CoV-2 from humans to farmed mink and back raises concerns of genetic variants with potential increased threat to human health. Mutations in the spike protein of SARS-CoV-2 from mink allow efficient entry into human cells and inhibition by ACE2, while mutation Y453F reduces neutralization by certain antibodies authorized for COVID-19 therapy. Antibody responses induced by infection or specific treatments might not offer adequate protection against SARS-CoV-2 variants from mink.
Article
Medicine, General & Internal
Dorota Zarebska-Michaluk et al.
Summary: Patients with kidney failure have a higher risk of severe COVID-19 and increased mortality rate. Age, baseline SpO(2), inflammatory markers, as well as other comorbidities are independent predictors of fatal outcome in COVID-19 patients with kidney disease.
JOURNAL OF CLINICAL MEDICINE
(2021)
Letter
Medicine, General & Internal
Aziz Sheikh et al.
Article
Multidisciplinary Sciences
Nash D. Rochman et al.
Summary: The evolution of SARS-CoV-2 during the COVID-19 pandemic is primarily characterized by purifying selection, with a small number of sites evolving under positive selection. Variants in the spike protein's receptor-binding domain and the nucleocapsid protein region with NLS are enriched with positively selected amino acid replacements. These replacements form a connected network of apparent epistatic interactions and are indicators of major partitions in the SARS-CoV-2 phylogeny. The global virus diversity has been steadily increasing, with distinct periods based on phylogenetic distances and key mutations.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Dorota Zarebska-Michaluk et al.
Summary: This study compared the effectiveness of tocilizumab (TCZ) and dexamethasone (DEX) administered alone or in combination in patients with severe COVID-19. The results showed that in severe patients, treatment with TCZ alone was better in terms of survival and clinical improvement than DEX, and the combination of TCZ and DEX did not improve therapy effectiveness.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Jeffrey C. Chandler et al.
Summary: Research indicates that white-tailed deer in the United States have been exposed to SARS-CoV-2, with 40% of samples testing positive for antibodies. This suggests that human infections of the novel coronavirus may have an impact on wildlife.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Veterinary Sciences
Katarzyna Domanska-Blicharz et al.
Summary: The study reported the infection of mink with SARS-CoV-2 on a farm in Poland and subsequent analysis of virus sequences from two isolates. The results can be useful for evaluating the epidemiological situation of SARS-CoV-2 in Poland and its impact on public health.
JOURNAL OF VETERINARY RESEARCH
(2021)
Article
Multidisciplinary Sciences
Bas B. Oude Munnink et al.
Summary: Animal experiments have shown that various animals can be infected by SARS-CoV-2, with evidence of animal-to-human transmission within mink farms. Investigation into mink farm outbreaks revealed that the virus was initially introduced by humans and has since evolved, causing transmission between mink farms. Despite enhanced biosecurity measures and culling, transmission occurred between farms in three large clusters with unknown modes of transmission, resulting in a high percentage of infections among mink farm residents and employees.
Review
Biochemistry & Molecular Biology
Joel Henrique Ellwanger et al.
Summary: Zoonotic spillover plays a fundamental role in the emergence of new human infectious diseases, and understanding the factors that facilitate pathogen transmission to humans is essential. Strategies focusing on reducing the frequency of spillover events can be established by considering various factors such as inter-species interactions, phylogenetic distance, and other specific characteristics.
GENETICS AND MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xi He et al.
