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A Renaissance for Oncolytic Adenoviruses?

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Oncolytic adenoviruses synergistically enhance anti-PD-L1 and anti-CTLA-4 immunotherapy by modulating the tumour microenvironment in a 4T1 orthotopic mouse model

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Summary: The study showed that combining oncolytic adenoviruses with anti-PD-L1 and anti-CTLA-4 treatment significantly inhibited tumor growth and prolonged survival in TNBC. The combination therapy recruited CD8(+) T and T memory cells, reduced regulatory T cells and tumor-associated macrophages, and promoted the polarization of macrophages to regulate the TME.

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Reversing resistance to immune checkpoint inhibitor by adding recombinant human adenovirus type 5 in a patient with small cell lung cancer with promoted immune infiltration: a case report

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Oncolytic adenovirus H101 ameliorate the efficacy of anti-PD-1 monotherapy in colorectal cancer

Lili Huang et al.

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The Oncolytic Adenovirus XVir-N-31, in Combination with the Blockade of the PD-1/PD-L1 Axis, Conveys Abscopal Effects in a Humanized Glioblastoma Mouse Model

Moritz Klawitter et al.

Summary: Oncolytic virotherapy (OVT) is a promising approach for the treatment of glioblastoma (GBM), and this study investigates the immunostimulatory effects of a YB-1 dependent oncolytic adenovirus (XVir-N-31) in comparison to wildtype adenovirus. The results show that XVir-N-31 induces immunogenic cell death and increases tumor infiltrating lymphocytes and NK cells in a mouse model. Combining OVT with immune checkpoint inhibition further enhances lymphocyte infiltration and reduces contralateral non-virus-injected tumors.

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Effective Combination Immunotherapy with Oncolytic Adenovirus and Anti-PD-1 for Treatment of Human and Murine Ovarian Cancers

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Cancer imaging and therapy utilizing a novel NIS-expressing adenovirus: The role of adenovirus death protein deletion

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Cytokine-Coding Oncolytic Adenovirus TILT-123 Is Safe, Selective, and Effective as a Single Agent and in Combination with Immune Checkpoint Inhibitor Anti-PD-1

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Summary: The oncolytic adenovirus TILT-123 shows safety in preclinical studies and has the potential to be used in combination with immune checkpoint inhibitors for cancer treatment. It exerts its therapeutic effect by activating T cells in the tumor microenvironment.
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Hyaluronidase expression within tumors increases virotherapy efficacy and T cell accumulation

Marti Farrera-Sal et al.

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ORCA-010, a Novel Potency-Enhanced Oncolytic Adenovirus, Exerts Strong Antitumor Activity in Preclinical Models

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Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14

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Treatment of Cancer Patients With a Serotype 5/3 Chimeric Oncolytic Adenovirus Expressing GMCSF

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Induction of type I interferon by adenovirus-encoded small RNAs

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