期刊
VIRUSES-BASEL
卷 14, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/v14122747
关键词
phylodinamics; PCR-genotyping; SARS-CoV-2 spread; genome sequencing; variants
类别
资金
- Rede Coronaomica BR MCTI/FINEP [FINEP 01.20.0029.000462/20, CNPq 404096/2020-4, 310627/2018-4]
- CNPq [310627/2018-4, 404096/2020-4]
- MEC/CAPES [14/2020-23072.211119/2020-10]
- FINEP [0494/20 01.20.0026.00, 1139/20]
- UFMG-NB3
- FAPEMIG [APQ-00475-20]
- FAPERJ [202.922/2018]
Since its first identification in Brazil, the Gamma variant has been associated with increased infection and transmission rates, leading to peaks of cases and deaths in Minas Gerais state. The study found Gamma to be the most common variant, but clusters of Zeta and Alpha variants were also observed. In addition, other rare variant lineages were identified. Genomic characterization estimated the introduction of Gamma in January 2021. The study emphasizes the importance of vaccination programs in preventing severe cases and deaths.
Since its first identification in Brazil, the variant of concern (VOC) Gamma has been associated with increased infection and transmission rates, hospitalizations, and deaths. Minas Gerais (MG), the second-largest populated Brazilian state with more than 20 million inhabitants, observed a peak of cases and deaths in March-April 2021. We conducted a surveillance study in 1240 COVID-19-positive samples from 305 municipalities distributed across MG's 28 Regional Health Units (RHU) between 1 March to 27 April 2021. The most common variant was the VOC Gamma (71.2%), followed by the variant of interest (VOI) zeta (12.4%) and VOC alpha (9.6%). Although the predominance of Gamma was found in most of the RHUs, clusters of Zeta and Alpha variants were observed. One Alpha-clustered RHU has a history of high human mobility from countries with Alpha predominance. Other less frequent lineages, such as P.4, P.5, and P.7, were also identified. With our genomic characterization approach, we estimated the introduction of Gamma on 7 January 2021, at RHU Belo Horizonte. Differences in mortality between the Zeta, Gamma and Alpha variants were not observed. We reinforce the importance of vaccination programs to prevent severe cases and deaths during transmission peaks.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据