Hyposplenism, an underrecognised immune diffeciency: Is sonography helpful?

The immunodeficiency syndrome of functional hyposplenia/asplenia is frequently unrecognized. The gold standard procedure for the diagnosis of this disease is technetium-99m scintigraphy of heat-denatured erythrocytes and the detection of pitted erythrocytes or Howell-Jolly bodies. Initial work suggests that this clinical presentation is associated with a small spleen. The aim of this review is to describe the value of B-mode and contrast-enhanced ultrasound in the identification of immunodeficiency caused by functional hyposplenism.

Automated summary

The immunodeficiency syndrome of functional hyposplenia/asplenia is often overlooked, but technetium-99m scintigraphy and ultrasound can aid in diagnosing this disease.