Patterns of use of recombinant zoster vaccine among commercially-insured immunocompetent and immunocompromised adults 50-64 years old in the United States

Purpose: The Centers for Disease Control and Prevention (CDC) recommends recombinant zoster vaccina-tion (RZV) for adults ??? 50 years to prevent herpes zoster (HZ) and its sequelae. Initially, no distinct rec-ommendation was made for immunocompromised adults, who experience higher HZ rates and more severe outcomes. We characterized receipt of first RZV dose (initiation) and both doses (completion) over time, and the impact of immune function on RZV uptake among adults aged 50???64 years in the United States. Methods: We identified RZV claims from the IBM MarketScan database between 1/1/2018 and 12/31/2019. We characterized immunocompromised enrollees as having malignancy, HIV, solid organ transplant, primary immunosuppression, or medication-induced immunosuppression using inpatient, outpatient, and prescription claims in the 6 months prior to study start. We evaluated patterns of vaccine uptake by demographic and healthcare access characteristics and immune status. Results: The cumulative incidence of RZV initiation during the study period was 10.0%. Incidence increased with age and number of medical office visits, and was higher among women, urban residents, high-deductible insurance beneficiaries, and those who were immunocompromised compared to immunocompetent. Among immunocompromised adults, RZV initiation was highest among those with HIV and primary immunodeficiencies. Of those who initiated RZV, 89.5% received both doses. RZV com-pletion was highest among those who received the first dose at a pharmacy. Most enrollees (88.6%) who completed RZV vaccination did so within the recommended dosing schedule. Conclusions: RZV uptake was low in the two years since the CDC recommendation, and differed by demo-graphic, healthcare access, and clinical characteristics. Initiation rates were higher among immunocom-promised adults compared to immunocompetent adults, despite no CDC recommendation for vaccination in these groups during the study period. The CDC has since recommended RZV for immunocompromised individuals, and our findings may inform efforts to increase RZV uptake in individuals at higher risk of severe disease. ?? 2022 Published by Elsevier Ltd.

Automated summary

The CDC recommends RZV vaccination for adults ??? 50 years to prevent herpes zoster. Immunocompromised adults had higher RZV initiation rates. RZV uptake was low in the two years following the CDC recommendation, with variations influenced by demographic, healthcare access, and clinical characteristics. Despite no CDC recommendation, immunocompromised individuals had higher initiation rates, and our findings may inform efforts to increase RZV uptake in high-risk individuals.