Corpus callosum-fastigium and tectal lengths in late-onset small fetuses

ObjectiveTo investigate measurements on neurosonography of midbrain morphology, including corpus callosum-fastigium length and tectal length, in late-onset small fetuses subclassified as small-for-gestational-age (SGA) or growth-restricted (FGR). MethodsThis was a case-control study of consecutive singleton pregnancies delivered at term at a single center between January 2019 and July 2021, including those with late-onset smallness (estimated fetal weight (EFW) < 10(th) centile) and appropriate-for-gestational-age controls matched by age at neurosonography. Small fetuses were further subdivided into SGA (EFW between 3(rd) and 9(th) centile and normal fetoplacental Doppler) and FGR (EFW < 3(rd) centile or EFW < 10(th) centile with abnormal cerebroplacental ratio and/or uterine artery Doppler). Transvaginal neurosonography was performed at a mean & PLUSMN; SD gestational age of 33 & PLUSMN; 1 weeks in all fetuses to evaluate corpus callosum-fastigium length and tectal length in the midsagittal plane. Intra- and interobserver agreement was evaluated using the intraclass correlation coefficient and Bland-Altman plots. ResultsA total of 70 fetuses with late-onset smallness (29 with SGA and 41 with FGR) and 70 controls were included. Compared with controls, small fetuses showed significantly shorter corpus callosum-fastigium length (median (interquartile range), 44.7 (43.3-46.8) mm vs 43.7 (42.4-45.5) mm, P < 0.001) and tectal length (mean & PLUSMN; SD, 10.5 & PLUSMN; 0.9 vs 9.6 & PLUSMN; 1.0 mm, P < 0.001). These changes were more prominent in FGR fetuses, with a linear trend across groups according to severity of smallness. Corpus callosum-fastigium length and tectal length measurements showed excellent intra- and interobserver reliability. ConclusionsSmall fetuses exhibited shorter corpus callosum-fastigium length and tectal length compared with controls, and these differences were more pronounced in fetuses with more severe smallness. These findings illustrate the potential value of midbrain measurements assessed on neurosonography as biomarkers for brain development in a high-risk population. However, further studies correlating these parameters with postnatal functional tests and follow-up are needed. & COPY; 2023 International Society of Ultrasound in Obstetrics and Gynecology.

Automated summary

This study aimed to investigate the measurements of midbrain morphology on neurosonography in late-onset small fetuses classified as small-for-gestational-age (SGA) or growth-restricted (FGR). The results showed that small fetuses had significantly shorter corpus callosum-fastigium length and tectal length compared to controls, and these differences were more pronounced in fetuses with more severe smallness. These findings suggest the potential value of midbrain measurements as biomarkers for brain development in a high-risk population.