☆ 4.4 Article

Effects of alpha-lipoic acid on sperm quality in patients with varicocele-related male infertility: study protocol for a randomized controlled clinical trial

TRIALS (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Andrology

Impact of Antioxidant Therapy on Natural Pregnancy Outcomes and Semen Parameters in Infertile Men: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Ashok Agarwal et al.

Summary: The meta-analysis found that antioxidant therapy can significantly improve the spontaneous pregnancy rate and conventional sperm parameters in male infertile patients. However, the impact of antioxidant therapy on live-birth rate is still controversial, as there are very few randomized controlled trials specifically evaluating this outcome.

WORLD JOURNAL OF MENS HEALTH (2023)

添加到收藏夹

Review Andrology

Oxidative versus reductive stress: a delicate balance for sperm integrity

Niloofar Sadeghi et al.

Summary: Recent evidence suggests that reductive stress, in addition to oxidative stress, plays a role in diseases such as male infertility. Excessive accumulation of reductants can lead to damaging mechanisms and the generation of ROS. Limited studies have been conducted on reductive stress, therefore antioxidant therapy remains a central approach in treating male infertility.

SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE (2023)

添加到收藏夹

Article Obstetrics & Gynecology

Microsurgical varicocelectomy effect on sperm telomere length, DNA fragmentation and seminal parameters

Sandra Lara-Cerrillo et al.

Summary: Varicocele is a major cause of male infertility, and microsurgical varicocelectomy appears to be an effective procedure for reducing testicular oxidative stress. However, it does not affect sperm telomere length and has only partial effects on seminal parameters and DNA damage in varicocele patients.

HUMAN FERTILITY (2022)

添加到收藏夹

Review Genetics & Heredity

Role of Oxidative Stress in Varicocele

Kaixian Wang et al.

Summary: According to WHO statistics, millions of couples and individuals suffer from infertility, with varicocele identified as a leading cause of male infertility. This review examines the role of oxidative stress and reactive oxygen species (ROS) in the pathophysiology of varicocele and its impact on fertility. High levels of ROS can lead to infertility by damaging DNA, affecting lipid peroxidation, and inactivating enzymes and proteins involved in spermatogenesis.

FRONTIERS IN GENETICS (2022)

添加到收藏夹

Review Andrology

Total antioxidant capacity-Relevance, methods and clinical implications

Sajal Gupta et al.

Summary: Oxidative stress is prevented by antioxidants, which are crucial for sperm health. Total antioxidant capacity (TAC) can aid in diagnosing male infertility, as infertile patients tend to have lower TAC levels. There is a positive correlation between TAC and seminal parameters, and evaluating TAC along with reactive oxygen species (ROS) and sperm DNA fragmentation index (DFI) may improve the accuracy of diagnosing male infertility.

ANDROLOGIA (2021)

添加到收藏夹

Review Urology & Nephrology

Vitamins as primary or adjunctive treatment in infertile men with varicocele: A systematic review

Georgios Tsampoukas et al.

Summary: Vitamins are often used as part of antioxidant treatment for infertile men with varicocele, showing positive impact on semen parameters. However, the effect on pregnancy rates needs further research.

ARAB JOURNAL OF UROLOGY (2021)

添加到收藏夹

Article Public, Environmental & Occupational Health

COVID-19 and sexual dysfunction in men: SARS-CoV-2 in the testes

A. M. Rabie

Summary: The study investigated the possible relationship between COVID-19 and sudden temporary sexual dysfunction in adult males, finding that many male patients experienced sexual problems during the pandemic and advocating for abstinence from sex during peak pandemic periods.

SEXOLOGIES (2021)

添加到收藏夹

Review Endocrinology & Metabolism

The role of alpha lipoic acid in female and male infertility: a systematic review

Chiara Di Tucci et al.

Summary: Alpha lipoic acid (ALA) shows beneficial effects in the treatment of female and male infertility, promoting oocyte maturation, improving fertilization and embryo development, and enhancing reproductive outcomes. Regular administration of ALA can also reduce pelvic pain in endometriosis patients, regulate menstrual flow and metabolic disorders, and improve sperm quality.

GYNECOLOGICAL ENDOCRINOLOGY (2021)

添加到收藏夹

Review Medicine, General & Internal

Male infertility

Ashok Agarwal et al.

Summary: Infertility affects 8-12% of couples globally, with male factors contributing to around 50%. The causes of male infertility are diverse, requiring thorough evaluation to identify treatable or reversible factors. Semen analysis is key for evaluation, while advanced tests have been developed to investigate sperm quality and function.

LANCET (2021)

添加到收藏夹

Article Andrology

Clinical effectiveness of microsurgical subinguinal varicocelectomy with enhanced recovery after surgery for varicocele

Xiaobin Wang et al.

Summary: Microsurgical subinguinal varicocelectomy (MSV) with enhanced recovery after surgery (ERAS) has been shown to significantly improve sperm quality and pregnancy outcomes, while providing effective pain relief and reducing recurrence and postoperative complications in patients with varicocele. The procedure under local anesthesia has demonstrated promising results in the treatment of male infertility.

TRANSLATIONAL ANDROLOGY AND UROLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

The Effect of Antioxidant Supplementation on Operated or Non-Operated Varicocele-Associated Infertility: A Systematic Review and Meta-Analysis

Nikolaos Pyrgidis et al.

Summary: This study reviewed 14 studies and found that antioxidant supplementation did not significantly improve fertility and semen parameters in patients with varicocele-associated infertility, with contradictory results reported. Most included studies raised methodological concerns, leading to the inability to draw definitive conclusions about the efficacy of antioxidant supplementation in this setting, highlighting the need for further research in the field.

ANTIOXIDANTS (2021)

添加到收藏夹

Article Urology & Nephrology

Varicocelectomy versus antioxidants in infertile men with isolated teratozoospermia: A retrospective analysis

Atef Fathi et al.

Summary: This study compared the outcomes of microscopic subinguinal varicocelectomy and oral antioxidants for treating male infertility due to isolated teratozoospermia. The results showed that varicocelectomy led to significant improvements in sperm morphology, SDF, and pregnancy rates compared to antioxidant treatment.

TURKISH JOURNAL OF UROLOGY (2021)

添加到收藏夹

Review Andrology

Efficacy of varicocelectomy for sperm DNA integrity improvement: A meta-analysis

Daoxian Qiu et al.

Summary: The meta-analysis evaluated the efficacy of varicocelectomy for sperm DNA integrity, with results showing a significant improvement in sperm DNA integrity among clinical varicocele patients following the surgery.

ANDROLOGIA (2021)

添加到收藏夹

Article Obstetrics & Gynecology

Alpha-lipoic acid improves sperm motility in infertile men after varicocelectomy: a triple-blind randomized controlled trial

Behzad Abbasi et al.

REPRODUCTIVE BIOMEDICINE ONLINE (2020)

添加到收藏夹

Article Urology & Nephrology

The effect of screening and treatment ofUreaplasma urealyticuminfection on semen parameters in asymptomatic leukocytospermia: a case-control study

Qi-Feng Zhang et al.

BMC UROLOGY (2020)

添加到收藏夹

Article Radiology, Nuclear Medicine & Medical Imaging

Validity of measurements of testicular volume obtained by a built-in software of ultrasound systems: with formula recommended by updated guidelines as reference

Dongyan Cai et al.

JOURNAL OF ULTRASONOGRAPHY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

α-Lipoic acid inhibits testicular and epididymal oxidative damage and improves fertility efficacy in arsenic-intoxicated rats

Papisetty Prathima et al.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2018)

添加到收藏夹

Article Andrology

Effect of adjuvant drug therapy after varicocelectomy on fertility outcome in males with varicocele-associated infertility: Systematic review and meta-analysis

Yin-Wei Chen et al.

ANDROLOGIA (2018)

添加到收藏夹

Article Medicine, Research & Experimental

The protective effects of alpha lipoic acid on methotrexate induced testis injury in rats

Neslihan Pinar et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

添加到收藏夹

Article Andrology

Alpha-Lipoic Acid improves the testicular dysfunction in rats induced by varicocele

Erfaneh Shaygannia et al.

ANDROLOGIA (2018)

添加到收藏夹

Article Biology

Lycopene and alpha-lipoic acid improve semen antioxidant enzymes activity and cashmere goat sperm function after cryopreservation

Fa Ren et al.

CRYOBIOLOGY (2018)

添加到收藏夹

Review Andrology

Role of oxidative stress, infection and inflammation in male infertility

Ashok Agarwal et al.

ANDROLOGIA (2018)

添加到收藏夹

Article Andrology

Tracing of zinc and iron in experimentally induced varicocele: correlation with oxidative, nitrosative and carbonyl stress

S. Gholirad et al.

ANDROLOGIA (2017)

添加到收藏夹

Review Urology & Nephrology

Varicocele and male infertility

Christian Fuglesang S. Jensen et al.

NATURE REVIEWS UROLOGY (2017)

添加到收藏夹

Article Andrology

The impact of vitamin E supplementation on semen parameters and pregnancy rates after varicocelectomy: a randomised controlled study

K. Ener et al.

ANDROLOGIA (2016)

添加到收藏夹

Review Andrology

Epidemiology of varicocele

Bader Alsaikhan et al.

ASIAN JOURNAL OF ANDROLOGY (2016)

添加到收藏夹

Review Andrology

Novel insights into the pathophysiology of varicocele and its association with reactive oxygen species and sperm DNA fragmentation

Chak-Lam Cho et al.

ASIAN JOURNAL OF ANDROLOGY (2016)

添加到收藏夹

Article Obstetrics & Gynecology

Randomized, triple-blind, placebo-controlled clinical trial examining the effects of alpha-lipoic acid supplement on the spermatogram and seminal oxidative stress in infertile men

Hossein Khadem Haghighian et al.

FERTILITY AND STERILITY (2015)

添加到收藏夹

Article Obstetrics & Gynecology

Twenty-four-hour monitoring of scrotal temperature in obesemen and men with a varicocele as a mirror of spermatogenic function

Andrea Garolla et al.

HUMAN REPRODUCTION (2015)

添加到收藏夹

Article Urology & Nephrology

The effect of adjuvant vitamin C after varicocele surgery on sperm quality and quantity in infertile men: a double blind placebo controlled clinical trial

Ali Cyrus et al.

INTERNATIONAL BRAZ J UROL (2015)

添加到收藏夹

Article Urology & Nephrology

Varicocele decreases epididymal neutral α-glucosidase and is associated with alteration of nuclear DNA and plasma membrane in spermatozoa

Giovanny Vivas-Acevedo et al.

BJU INTERNATIONAL (2014)

添加到收藏夹

Article Obstetrics & Gynecology

Report on varicocele and infertility: a committee opinion

FERTILITY AND STERILITY (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

Alpha-Lipoic Acid and N-Acetylcysteine Protects Intensive Swimming Exercise-Mediated Germ-Cell Depletion, Pro-Oxidant Generation, and Alteration of Steroidogenesis in Rat Testis

Kuladip Jana et al.

MOLECULAR REPRODUCTION AND DEVELOPMENT (2014)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.