期刊
TRENDS IN PHARMACOLOGICAL SCIENCES
卷 44, 期 2, 页码 98-111出版社
CELL PRESS
DOI: 10.1016/j.tips.2022.11.003
关键词
-
G protein G beta gamma subunits play crucial roles in G protein-coupled receptor signaling and have been targeted for disease treatments. Recent studies have discovered non-canonical activation of G beta gamma at intracellular organelles, particularly the Golgi apparatus, where it regulates cell processes and can be targeted for therapeutic interventions. Inhibiting Golgi-compartmentalized G beta gamma signaling has shown promise in attenuating cardiomyocyte hypertrophy and prostate tumorigenesis.
G protein G beta gamma subunits are key mediators of G protein-coupled receptor (GPCR) signaling under physiological and pathological conditions; their inhibitors have been tested for the treatment of human disease. Conventional wisdom is that the G beta gamma complex is activated and subsequently exerts its functions at the plasma mem-brane (PM). Recent studies have revealed non-canonical activation of G beta gamma at intra-cellular organelles, where the Golgi apparatus is a major locale, via translocation or local activation. Golgi-localized G beta gamma activates specific signaling cascades and reg-ulates fundamental cell processes such as membrane trafficking, proliferation, and migration. More recent studies have shown that inhibiting Golgi-compartmentalized G beta gamma signaling attenuates cardiomyocyte hypertrophy and prostate tumorigenesis, indicating new therapeutic targets. We review novel activation mechanisms and non-canonical functions of G beta gamma at the Golgi, and discuss potential therapeutic inter-ventions by targeting Golgi-biased G beta gamma-directed signaling.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据